Kerstin Lindblad-Toh | |
---|---|
![]() Lindblad-Toh in 2013 | |
Born | |
Citizenship | Swedish and American |
Known for | The 200 Mammals Project, Mammalian Genomes, Dog Disease Genetics |
Scientific career | |
Fields | Comparative Genomics, Human Genetics, Immunology, Cancer |
Institutions | Broad Institute and Uppsala University |
Thesis | (1998) |
Kerstin Lindblad-Toh is a scientist in comparative genomics, specializing in mammalian genetics. She is the Scientific Director of vertebrate genomics at the Broad Institute [1] and a professor in comparative genomics at Uppsala University. [2] In 2010 she co-founded Science for Life Laboratory (SciLifeLab) together with Mathias Uhlén and acted as Co-Director until 2015. As the leader of the Broad Institute's Mammalian Genome Initiative she has led the effort to sequence and analyze the genomes of various mammals, including mouse, dog, chimpanzee, horse, rabbit and opossum. [3] She has researched extensively on the genetics of dogs, identifying genes and genetic variants important in disease susceptibility, morphology and behavior. [1]
Lindblad-Toh is elected to the National Academy of Sciences of the United States and the Royal Swedish Academy of Sciences. [4]
Lindblad-Toh was born 1970 in Stockholm, Sweden. She studied molecular biology as an undergraduate at Karolinska Institute. [5] In 1988, she received her Ph.D. from the Department of Molecular Medicine at Karolinska Institute. She worked on several projects as a postdoctoral fellow at the Whitehead Institute/MIT Center for Genome Research together with Eric Lander, including mouse SNP discovery, the development of genotyping technologies and association studies in human disease. [6] In 2002, she co-authored the paper describing the initial genome sequence of the mouse, [7] and in 2005 she published the first genome sequence of the domestic dog. [8]
Uppsala University is a public research university in Uppsala, Sweden. Founded in 1477, it is the oldest university in Sweden and the Nordic countries still in operation.
Svante Pääbo is a Swedish geneticist and Nobel Laureate who specialises in the field of evolutionary genetics. As one of the founders of paleogenetics, he has worked extensively on the Neanderthal genome. In 1997, he became founding director of the Department of Genetics at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. Since 1999, he has been an honorary professor at Leipzig University; he currently teaches molecular evolutionary biology at the university. He is also an adjunct professor at Okinawa Institute of Science and Technology, Japan.
Theodor Svedberg was a Swedish chemist and Nobel laureate for his research on colloids and proteins using the ultracentrifuge. Svedberg was active at Uppsala University from the mid-1900s to late 1940s. While at Uppsala, Svedberg started as a docent before becoming the university's physical chemistry head in 1912. After leaving Uppsala in 1949, Svedberg was in charge of the Gustaf Werner Institute until 1967. Apart from his 1926 Nobel Prize, Svedberg was named a Foreign Member of the Royal Society in 1944 and became part of the National Academy of Sciences in 1945.
The Royal Society of Sciences in Uppsala, is the oldest of the royal academies in Sweden, having been founded in 1710. The society has, by royal decree of 1906, 50 Swedish fellows and 100 foreign.
Eric Steven Lander is an American mathematician and geneticist who served as the 11th director of the Office of Science and Technology Policy and Science Advisor to the President, serving on the presidential Cabinet. Lander is a professor of biology at the Massachusetts Institute of Technology (MIT), a professor of systems biology at Harvard Medical School, a former member of the Whitehead Institute. Eric Lander is a core institute member and founding director emeritus of the Broad Institute of MIT and Harvard. He served as president and founding director from Broad's inception until 2021. He is a 1987 MacArthur Fellow and Rhodes Scholar. Lander co-chaired President Barack Obama's Council of Advisors on Science and Technology. Lander announced he would resign from the Biden Administration effective February 18, 2022, after allegations surfaced he had engaged in bullying and abusive conduct directed against his subordinates and other White House staff. Since 2023, Eric Lander has returned to his tenured professor positions at MIT and Harvard as well as Broad as a Core Institute Member and Founding Director Emeritus.
Comparative genomics is a field of biological research in which the genomic features of different organisms are compared. The genomic features may include the DNA sequence, genes, gene order, regulatory sequences, and other genomic structural landmarks. In this branch of genomics, whole or large parts of genomes resulting from genome projects are compared to study basic biological similarities and differences as well as evolutionary relationships between organisms. The major principle of comparative genomics is that common features of two organisms will often be encoded within the DNA that is evolutionarily conserved between them. Therefore, comparative genomic approaches start with making some form of alignment of genome sequences and looking for orthologous sequences in the aligned genomes and checking to what extent those sequences are conserved. Based on these, genome and molecular evolution are inferred and this may in turn be put in the context of, for example, phenotypic evolution or population genetics.
Ludvig Dmitrievich Faddeev was a Soviet and Russian mathematical physicist. He is known for the discovery of the Faddeev equations in the theory of the quantum mechanical three-body problem and for the development of path integral methods in the quantization of non-abelian gauge field theories, including the introduction of Faddeev–Popov ghosts. He led the Leningrad School, in which he along with many of his students developed the quantum inverse scattering method for studying quantum integrable systems in one space and one time dimension. This work led to the invention of quantum groups by Drinfeld and Jimbo.
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Tatyana Olegovna Shaposhnikova is a Russian-born Swedish mathematician. She is best known for her work in the theory of multipliers in function spaces, partial differential operators and history of mathematics, some of which was partly done jointly with Vladimir Maz'ya. She is also a translator of both scientific and literary texts.
Dorothea Bennett was a geneticist, known for the genetics of early mammalian development and for research into mammalian sperm surface structures and their role in fertilization and spermatogenesis. She was "one of the major figures in mouse developmental genetics".
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Peter (Petre) Stoica is a researcher and educator in the field of signal processing and its applications to radar/sonar, communications and bio-medicine. He is a professor of Signals and Systems Modeling at Uppsala University in Sweden, and a Member of the Royal Swedish Academy of Engineering Sciences, the United States National Academy of Engineering (International Member), the Romanian Academy, the European Academy of Sciences, and the Royal Society of Sciences. He is also a Fellow of IEEE, EURASIP, IETI, and the Royal Statistical Society.
Emmanuelle Marie Charpentier is a French professor and researcher in microbiology, genetics, and biochemistry. As of 2015, she has been a director at the Max Planck Institute for Infection Biology in Berlin. In 2018, she founded an independent research institute, the Max Planck Unit for the Science of Pathogens. In 2020, Charpentier and American biochemist Jennifer Doudna of the University of California, Berkeley, were awarded the Nobel Prize in Chemistry "for the development of a method for genome editing". This was the first science Nobel Prize ever won by two women only.
Katherine Belov is an Australian geneticist, professor of comparative genomics in the School of Life and Environmental Sciences and Pro Vice Chancellor of Global Engagement at the University of Sydney. She is head of the Australasian Wildlife Genomics Group and research expert in the area of comparative genomics and immunogenetics, including Tasmanian devils and koalas, two iconic Australian species that are threatened by disease processes. Throughout her career, she has disproved the idea that marsupial immune system is primitive, characterized the South American gray short-tailed opossum's immune genes, participated in the Platypus Genome Project, led research identifying the properties of platypus venom, and identified the cause of the spread of the Tasmanian devil's contagious cancer.
Björkénska priset is a scientific award given by Uppsala University. It is awarded for outstanding research in science and the theoretical branches of medicine. The prize was established in 1893 from a donation given by university lecturer John Björkén (1833–1893). Björkén was a physician and medical assistant professor in surgery and obstetrics at Uppsala. The prize was first awarded in 1902 on the day of his death.
Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology (MIT) in the area of Computational Biology and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.
Kristina Edström is a Swedish Professor of Inorganic Chemistry at Uppsala University. She also serves as Head of the Ångström Advanced Battery Centre (ÅABC) and has previously been both Vice Dean for Research at the Faculty of Science and Technology and Chair of the STandUp for Energy research programme.
Siv Gun Elisabeth Andersson is a Swedish evolutionary biologist, professor of molecular evolution at Uppsala University. She is member of both the Royal Swedish Academy of Sciences and of Engineering. She is also Head of basic research at the Knut and Alice Wallenberg Foundation and has been co-director of the Swedish national center for large-scale research Science for Life Laboratory between 2017 and 2021. Her research focuses on the evolution of bacteria, mainly on intracellular parasites.
Judith Elizabeth Mank is an American-British zoologist who is a Canada 150 Chair at the University of British Columbia. Her research considers how selection produces variations in form. She is interested in sexual dimorphism and the formation of sex chromosomes.
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