Kim Orth | |
---|---|
Alma mater | |
Scientific career | |
Institutions |
Kim Orth is a microbiologist and biochemist. She is the Earl A. Forsythe chair in biomedical science and professor of molecular biology and biochemistry at UT Southwestern. [1] She is a Howard Hughes Medical Institute investigator [2] and a member of the National Academy of Sciences. Her research focuses on bacterial pathogenesis. [3]
Kim Orth graduated from Texas A&M University in 1984 with a B.S. in biochemistry. She went to the UCLA School of Medicine for an M.S. in biological chemistry, and then to University of Texas Southwestern Medical Center for a PhD in biochemistry and molecular biology. [4]
After obtaining her PhD in Biological Chemistry at UT Southwestern Medical Center, she moved with her husband to the University of Michigan. Over the course of 7 years at University of Michigan, she had multiple productive postdocs in various fields while becoming a working mother of two. During her final postdoc at the University of Michigan, she discovered the field of host-pathogen interactions. After two years of working in this field, she accepted faculty position in 2001 at UT Southwestern Medical Center in the Department of Molecular Biology, and became an Earl A. Forsythe Chair in Biomedical Science.
Over the years, she worked in labs doing protein chemistry, Drosophilia genetics, cell biology, biochemistry and molecular microbial genetics. Using these tools, Dr. Orth developed a program to identify bacterial virulence factors and uncover their molecular activity. [5]
The University of Texas Southwestern Medical Center is a public academic health science center in Dallas, Texas. With approximately 23,000 employees, more than 3,000 full-time faculty, and nearly 4 million outpatient visits per year, UT Southwestern is the largest medical school in the University of Texas System and state of Texas. The institution has been consistently ranked among the top medical schools in the United States.
Joseph Leonard Goldstein ForMemRS is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas Southwestern researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs.
John Kuriyan is the dean of basic sciences and a professor of biochemistry at Vanderbilt University School of Medicine. He was formerly the Chancellor's Professor at the University of California, Berkeley in the departments of molecular and cell biology (MCB) and chemistry, a faculty scientist in Berkeley Lab's physical biosciences division, and a Howard Hughes Medical Institute investigator. He is a member of the National Academy of Sciences and he has also been on the Life Sciences jury for the Infosys Prize in 2009, 2019 and 2020.
The American Society for Biochemistry and Molecular Biology (ASBMB) is a learned society that was founded on December 26, 1906, at a meeting organized by John Jacob Abel. The roots of the society were in the American Physiological Society, which had been formed some 20 years earlier. ASBMB is the US member of the International Union of Biochemistry and Molecular Biology.
Helmut Beinert was a professor in the biochemistry department at the University of Wisconsin–Madison. His research focused on the mechanism of enzymes, in particular metalloenzymes and iron-sulfur proteins. He was elected to the National Academy of Sciences in 1980.
Zhijian "James" Chen is a Chinese-American biochemist and professor in the department of molecular biology at University of Texas Southwestern Medical Center. He is best known for his discovery of mechanisms by which nucleic acids trigger innate and autoimmune responses from the interior of a cell, work for which he received the 2019 Breakthrough Prize in Life Sciences.
Natalie G. Ahn is a professor of chemistry and biochemistry at the University of Colorado at Boulder. Her research is focused on understanding the mechanisms of cell signaling, with a speciality in phosphorylation and cancers. Ahn's work uses the tools of "classical chemistry" to work on understanding the genetic code and how genetics affects life processes. She has been a professor at the University of Colorado at Boulder since 2003, where she is a distinguished professor. She was a Howard Hughes Medical Institute investigator between 1994 and 2014. In 2018, she was elected to the National Academy of Sciences and named a fellow of the American Academy of Arts and Sciences.
Ronald R. Breaker is an American biochemist who is a Sterling Professor of Molecular, Cellular, and Developmental Biology at Yale University. He is best known for the discovery of riboswitches. His current research is focused on understanding advanced functions of nucleic acids, including the discovery and analysis of riboswitches and ribozymes.
Sheena Elizabeth Radford FRS FMedSci is a British biophysicist, and Astbury Professor of Biophysics in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds. Radford is the Associate Editor of the Journal of Molecular Biology.
Mary Jane Osborn was an American biochemist and microbiologist known for her research on the biosynthesis of lipopolysaccharide, a key component of the outer membrane of Gram-negative bacteria, and discovering the mechanism of action of the anti-cancer drug methotrexate. She headed the Department of Molecular Biology and Biophysics at the University of Connecticut Health Center and served as president of the American Society for Biochemistry and Molecular Biology.
G. Marius Clore MAE, FRSC, FRS is a British-born, Anglo-American molecular biophysicist and structural biologist. He was born in London, U.K. and is a dual U.S./U.K. Citizen. He is a Member of the National Academy of Sciences, a Fellow of the Royal Society, a NIH Distinguished Investigator, and the Chief of the Molecular and Structural Biophysics Section in the Laboratory of Chemical Physics of the National Institute of Diabetes and Digestive and Kidney Diseases at the U.S. National Institutes of Health. He is known for his foundational work in three-dimensional protein and nucleic acid structure determination by biomolecular NMR spectroscopy, for advancing experimental approaches to the study of large macromolecules and their complexes by NMR, and for developing NMR-based methods to study rare conformational states in protein-nucleic acid and protein-protein recognition. Clore's discovery of previously undetectable, functionally significant, rare transient states of macromolecules has yielded fundamental new insights into the mechanisms of important biological processes, and in particular the significance of weak interactions and the mechanisms whereby the opposing constraints of speed and specificity are optimized. Further, Clore's work opens up a new era of pharmacology and drug design as it is now possible to target structures and conformations that have been heretofore unseen.
Susan Taylor is an American biochemist who is a Professor of Chemistry and Biochemistry and a Professor of Pharmacology at the University of California, San Diego. She is known for her research on protein kinases, particularly protein kinase A. She was elected to the Institute of Medicine and the United States National Academy of Sciences in 1996.
Steven Lanier McKnight is a professor and former chair of the department of biochemistry at UT Southwestern. His research is in the area of transcriptional regulation.
Ruma Banerjee is a professor of enzymology and biological chemistry at the University of Michigan Medical School. She is an experimentalist whose research has focused on unusual cofactors in enzymology.
Christine Jacobs-Wagner is a microbial molecular biologist. She is the William H. Fleming, MD Professor of Molecular, Cellular, and Developmental Biology at Yale University and Professor of Microbial Pathogenesis, HHMI investigator, and director of the Microbial Sciences Institute at Yale Medical School. Jacobs-Wagner's research has shown that bacterial cells have a great deal of substructure, including analogs of microfilaments, and that proteins are directed by regulatory processes to locate to specific places within the bacterial cell. She was elected to the National Academy of Sciences in 2015 and has received a number of scientific awards.
Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University. and an Investigator for Howard Hughes Medical Institute. Pyle is the president of the RNA Society, the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section at the National Institutes of Health.
Barry H. Honig is an American biochemist, molecular biophysicist, and computational biophysicist, who develops theoretical methods and computer software for "analyzing the structure and function of biological macromolecules."
Alexandra C. Newton is a Canadian and American biochemist. She is a Distinguished Professor of pharmacology at the University of California, San Diego. Newton runs a multidisciplinary Protein kinase C and Cell signaling biochemistry and cell biology research group in the School of Medicine, investigating molecular mechanisms of signal transduction in the Phospholipase C (PLC) and Phosphoinositide 3-kinase signaling pathways. She has been continuously funded by the US National Institutes of Health since 1988.
Joan Weliky Conaway is an American biochemist who researches gene transcription. She worked at the Stowers Institute for Medical Research from 2001 to 2021 and currently serves as vice provost and dean for basic research at the University of Texas Southwestern Medical Center. She is a member of the National Academy of Sciences and American Academy of Arts and Sciences.
Erinna Lee is a Singaporean molecular biologist specializing in apoptosis and autophagy.