Knight Cancer Institute

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The OHSU Knight Cancer Institute (previously the OHSU Cancer Institute) is a research institute within Oregon Health & Science University. The National Cancer Institute (NCI) designated cancer center is led by director Tom Sellers. [1] [2] It is the only NCI-designated Comprehensive Cancer Center in the state of Oregon. [3] The institute is named after Phil Knight and his wife, who donated over $600 million to the center; $100 million in 2008 and $500 million in 2013. [4] The $500 million gift required a matching $500 million, which led to a $100 million donation by Columbia Sportswear chairwoman Gert Boyle in 2014. [5]

Contents

History

The institute was first designated as a NCI Designated Cancer Center in 1997 and was awarded the status of comprehensive cancer center in 2017. [6] Brian Druker was named the director of the then OHSU Cancer Institute in 2007. [5] Tom Sellers took over as director in 2024. [7]

Research areas

The Knight Cancer Institute employs over 200 investigators who are affiliated with one of four Cancer Research Programs: Cancer Biology, Cancer Prevention and Control, Quantitative Oncology, and Translational Oncology. [8] [9] The Cancer Biology program focuses on tumorigenesis, signal transduction, and the tumor microenvironment. [10] It is led by researchers Mara Sherman and Melissa Wong. Susan Flocke and Kerri Winters-Stone lead the Cancer Prevention and Control research program, which explores cancer prevention and risk reduction, screening and early detection, and survivorship. [11] The Quantitative Oncology program focuses on technology development, molecular characterization, and systems biology. [12] The fourth research program, Translational Oncology, has themes of target validation and high-impact interventions. [13] This program is led by Lara Davis and Jeffrey Tyner.

Related Research Articles

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Oregon Health & Science University (OHSU) is a public research university focusing primarily on health sciences with a main campus, including two hospitals, in Portland, Oregon. The institution was founded in 1887 as the University of Oregon Medical Department and later became the University of Oregon Medical School. In 1974, the campus became an independent, self-governed institution called the University of Oregon Health Sciences Center, combining state dentistry, medicine, nursing, and public health programs into a single center. It was renamed Oregon Health Sciences University in 1981 and took its current name in 2001, as part of a merger with the Oregon Graduate Institute (OGI), in Hillsboro. The university has several partnership programs including a joint PharmD Pharmacy program with Oregon State University in Corvallis.

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<span class="mw-page-title-main">David Gius</span> American physician-scientist

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Kent L. Thornburg is an American scientist, researcher and professor. He lives in Portland, Oregon and works at Oregon Health & Science University (OHSU), in the School of Medicine. He is the director for both the OHSU Center for Developmental Health and the Moore Institute for Nutrition & Wellness

<span class="mw-page-title-main">Melissa Haendel</span> American bioinformaticist

Melissa Anne Haendel is an American bioinformaticist who is the Sarah Graham Kenan Distinguished Professor at the UNC School of Medicine. She is also the Director of Precision Health & Translational Informatics, deputy director of Computational Science at The North Carolina Translational and Clinical Sciences Institute. She serves as Director of the Center for Data to Health (CD2H). Her research makes use of data to improve the discovery and diagnosis of diseases. During the COVID-19 pandemic, Haendel joined with the National Institutes of Health to launch the National COVID Cohort Collaborative (N3C), which looks to identify the risk factors that can predict severity of disease outcome and help to identify treatments.

Hildegard Lamfrom was a German-American molecular biologist/biochemist. She helped develop one of the first in-vitro translation systems, using rabbit reticulocyte lysate to study protein synthesis in a cell-free context. This allowed her to make a number of contributions to the field including providing some of the first direct evidence for the existence of messenger RNA (mRNA) as a protein template, as well as the existence of polyribosomes.

Melissa Wong is an American biologist known for her work describing cell fusion, the cancer stem cell niche, and early detection strategies. She currently holds appointments at Oregon Health & Science University in the Department of Cell, Developmental and Cancer Biology and co-leads the Knight Cancer Institute's Cancer Biology program.

Lisa M. Coussens is an American cancer scientist who is Professor and Chair of the Department of Cell, Developmental and Cancer Biology and Deputy Director for Basic and Translational Research in the Knight Cancer Institute at the Oregon Health & Science University. She served as 2022-2023 President of the American Association for Cancer Research.

References

  1. ↑ Gibbs, Amanda. "OHSU Knight Cancer Institute announces leadership transition". OHSU News. Retrieved 2024-12-16.
  2. ↑ "Thomas A Sellers Ph.D., M.P.H. | OHSU People | OHSU". www.ohsu.edu. Retrieved 2024-12-16.
  3. ↑ "Knight Cancer Institute Mission and History | Knight Cancer Institute | OHSU". www.ohsu.edu. Retrieved 2022-01-03.
  4. ↑ Theen, Andrew (September 21, 2013). "Phil and Penny Knight to OHSU: $500 million is yours for cancer research if you can match it". The Oregonian/OregonLive. Retrieved 28 June 2017.
  5. 1 2 Budnick, Nick (August 29, 2014). "The story behind Gert Boyle's $100-million gift for cancer research at Oregon Health & Science University". The Oregonian/OregonLive.com . Retrieved June 28, 2017.
  6. ↑ "National Cancer Institute Designated Cancer Center". Oregon Health & Science University. Retrieved 28 June 2017.
  7. ↑ Gibbs, Amanda. "OHSU Knight Cancer Institute announces leadership transition". OHSU News. Retrieved 2024-12-16.
  8. ↑ "Knight Cancer Institute - National Cancer Institute". www.cancer.gov. 2012-07-27. Retrieved 2022-01-03.
  9. ↑ "Cancer Research Programs | Knight Cancer Institute | OHSU". www.ohsu.edu. Retrieved 2022-01-03.
  10. ↑ "Cancer Biology Research | Knight Cancer Institute | OHSU". www.ohsu.edu. Retrieved 2022-01-03.
  11. ↑ "Cancer Prevention and Control Research | Knight Cancer Institute | OHSU". www.ohsu.edu. Retrieved 2022-01-03.
  12. ↑ "Quantitative Oncology Research | Knight Cancer Institute | OHSU". www.ohsu.edu. Retrieved 2022-01-03.
  13. ↑ "Translational Oncology Research | Knight Cancer Institute | OHSU". www.ohsu.edu. Retrieved 2022-01-03.
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