NCI-designated Cancer Centers are a group of 72 cancer research institutions in the United States supported by the National Cancer Institute. [1]
Three designations are recognized: Comprehensive Cancer Centers, Clinical Cancer Centers, and Basic Laboratory Cancer Centers. As of November 2024, there are 57 Comprehensive Cancer Centers, 8 Clinical Cancer Centers, and 7 Basic Laboratory Cancer Centers. [1] Almost all are associated with a university. Receiving the NCI-designation places cancer centers among the top 4 percent of the approximately 1,500 cancer centers in the United States.
The standards for Comprehensive Cancer Centers are the most restrictive of the types. These facilities must demonstrate expertise in each of three areas: laboratory, clinical, and behavioral and population-based research. Comprehensive Cancer Centers are expected to initiate and conduct early phase, innovative clinical trials and to participate in the NCI's cooperative groups by providing leadership and recruiting patients for trials. Comprehensive Cancer Centers must also conduct activities in outreach and education, and provide information on advances in healthcare for both healthcare professionals and the public. Comprehensive cancer centers may apply for up to $1.5 million per year from the Department of Health and Human Services. [2]
Clinical Cancer Centers generally conduct a combination of basic, population sciences, and clinical research, and are encouraged to stimulate collaborative research involving more than one field of study. Clinical cancer centers may apply for up to $1.4 million per year.
Basic Laboratory Cancer Centers conduct only laboratory research and do not provide patient treatment. Basic Laboratory Cancer Centers are more often affiliated with research institutes rather than universities. They are eligible to apply for up to $1.2 million per year. [2]
Independent or freestanding cancer centers are entities unto themselves and are not considered to be part of a larger institution or university. The center’s administration controls all space, appointments, and budgets. These institutions may have university affiliations, but they remain administratively and financially distinct. [3]
The NCI also supports Consortium Centers, wherein scientists and clinicians from multiple institutions enter into formal agreements to expand cancer research programs. [2] Importantly, Consortium Partners are not themselves considered NCI-designated. The NCI has strict guidelines on how Consortium Partners can refer to their relationship with their parent Consortium Center.
These grants fund shared resources to further the goals of the National Cancer Institute. Some of these include the administration of cancer research programs, training activities, core facilities with technology shared by investigators, and clinical trial management services. [2]
In 2015, more than 353,000 new patients were enrolled in a clinical trial at an NCI-designated Cancer Center. [4]
Cancer centers must renew their status with the NIH every 5 years. The NIH funds cancer centers through a P30 Cancer Center Support Grant (CCSG) mechanism. [2] To be eligible to apply, a cancer center must receive at least $10 million in cancer research funding annually. Preparation for these grant applications can be extensive. The most recent grant application prepared by MD Anderson Cancer Center took 24 months to prepare and ran to 2,963 pages. [5]
The NCI considers the certain characteristics essential to a cancer center, and requires that applications address the institutions' resources in the areas of: Physical Space, Organizational Capabilities, Transdisciplinary Collaboration and Coordination, Cancer Focus, Institutional Commitment, Center Director. [2]
Source: NCI [6]
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship.
The University of Texas MD Anderson Cancer Center is a comprehensive cancer center in Houston, Texas. It is the largest cancer center in the world and one of the original three NCI-designated comprehensive cancer centers in the country. It is both a degree-granting academic institution and a cancer treatment and research center located within the Texas Medical Center, the largest medical center and life sciences destination in the world. MD Anderson Cancer Center has consistently ranked #1 among the best hospitals for cancer care and research in the U.S. and worldwide, and it has held the #1 position 20 times in the last 23 years in U.S. News & World Report's Best Hospitals rankings for cancer care. As of 2023, MD Anderson Cancer Center is home to the highest number of cancer clinical trials in the world and has received more NCI-funded projects than any other U.S. institute. For 2024, Newsweek placed MD Anderson at #1 in their annual list of the World's Best Specialized Hospitals in oncology.
Roswell Park Comprehensive Cancer Center is a cancer research and treatment center located in Buffalo, New York. Founded by surgeon Roswell Park in 1898, the center was the first in the United States to specifically focus on cancer research. The center is usually called Roswell Park in short. The center, which conducts clinical research on cancer as well as the development new drugs, provides advanced treatment for all forms of adult and pediatric cancer, and serves as a member of the National Comprehensive Cancer Network. Roswell Park Comprehensive Cancer Center is as of 2019, the only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center".
UC Davis Medical Center (UCDMC) is part of UC Davis Health and a major academic health center located in Sacramento, California. It is owned and operated by the University of California as part of its University of California, Davis campus. The medical center sits on a 142-acre (57 ha) campus (often referred to as the Sacramento Campus to distinguish it from the main campus in nearby Davis) located between the Elmhurst, Tahoe Park, and Oak Park residential neighborhoods. The site incorporates the land and some of the buildings of the former Sacramento Medical Center (which was acquired from the County of Sacramento in 1973) as well as much of the land (and two buildings) previously occupied by the California State Fair until its 1967 move to a new location.
UC San Diego Health is the academic health system of the University of California, San Diego in San Diego, California. It is the only academic health system serving San Diego and has one of three adult Level I trauma centers in the region. In operation since 1966, it comprises three major hospitals: UC San Diego Medical Center in Hillcrest, Jacobs Medical Center in La Jolla, and East Campus Medical Center at UC San Diego Health in East County. The La Jolla campus also includes the Moores Cancer Center, Shiley Eye Institute, Sulpizio Cardiovascular Center, and Koman Family Outpatient Pavilion, and the health system also includes several outpatient sites located throughout San Diego County. UC San Diego Health works closely with the university's School of Medicine and Skaggs School of Pharmacy to provide training to medical and pharmacy students and advanced clinical care to patients.
Dana–Farber Cancer Institute (DFCI) is a comprehensive cancer treatment and research center in Boston, Massachusetts. Dana-Farber is the founding member of the Dana-Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School.
The University of California, San Diego School of Medicine is the graduate medical school of the University of California, San Diego, a public land-grant research university in La Jolla, California. It was the third medical school in the University of California system, after those established at UCSF and UCLA, and is the only medical school in the San Diego metropolitan area. It is closely affiliated with the medical centers that are part of UC San Diego Health.
The mission of the Multiple Myeloma Research Consortium (MMRC) is to champion collaboration with and integration across academia and industry and to focus on speed and innovation to bring the most promising multiple myeloma treatments to patients faster. It was founded by Kathy Giusti, a myeloma patient and founder and chief executive officer of the Multiple Myeloma Research Foundation (MMRF).
City of Hope is a private, non-profit clinical research center, hospital and graduate school located in Duarte, California, United States. The center's main campus resides on 110 acres (45 ha) of land adjacent to the boundaries of Duarte and Irwindale, with a network of clinical practice locations throughout Southern California, satellite offices in Monrovia and Irwindale, and regional fundraising offices throughout the United States.
Sanford Burnham Prebys is a 501(c)(3) non-profit medical research institute focused on basic and translational research, with major research programs in cancer, neurodegeneration, diabetes, infectious, inflammatory, and childhood diseases. The institute also specializes in stem cell research and drug discovery technologies.
The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) is a National Cancer Institute (NCI)-designated comprehensive cancer center located in Baltimore, Maryland.
Scripps Health is a nonprofit health care system based in San Diego, California. The system includes five hospital campuses and 30 outpatient centers and clinics, and treats more than 600,000 patients annually through 3,000 affiliated physicians. The system also includes clinical research and medical education programs.
Edison T. Liu is an American chemist who is the former president and CEO of The Jackson Laboratory, and the former director of its NCI-designated Cancer Center (2012-2021). Before joining The Jackson Laboratory, he was the founding executive director of the Genome Institute of Singapore (GIS), chairman of the board of the Health Sciences Authority, and president of the Human Genome Organization (HUGO) (2007-2013). As the executive director of the GIS, he brought the institution to international prominence as one of the most productive genomics institutions in the world.
Medical centers in the United States are conglomerations of health care facilities including hospitals and research facilities that also either include or are closely affiliated with a medical school.
The University of Wisconsin Carbone Cancer Center (UWCCC) is a comprehensive cancer center in Wisconsin, as designated by the National Cancer Institute (NCI), the lead federal agency for cancer research. It is an integral part of both the University of Wisconsin (UW) and the University of Wisconsin Hospital and Clinics. It is located in Madison, Wisconsin.
Gibbs Cancer Center & Research Institute is a cancer treatment and research facility in Upstate South Carolina. Gibbs Cancer Center is associated with the NCI Community Cancer Centers Program and the Medical University of South Carolina. Gibbs has several locations across the upstate of South Carolina, including Comprehensive Cancer Centers at both Spartanburg Medical Center and Pelham Medical Center. Additional infusion facilities are located in Gaffney, Union, Mary Black and North Grove.
Founded in 1974, VCU Massey Comprehensive Cancer Center is a non-profit organization part of Virginia Commonwealth University. Located in Richmond, Virginia, Virginia Commonwealth University is one of the nation's top research universities, and VCU Medical Center, a leading academic health system ranked Virginia's top hospital by U.S. News & World Report in 2012.
Seattle Cancer Care Alliance (SCCA) is a cancer treatment and research center in Seattle, Washington. Established in 1998, this nonprofit provides clinical oncology care for patients treated at its three partner organizations: Fred Hutchinson Cancer Research Center, Seattle Children's and UW Medicine. Together, these four institutions form the Fred Hutch/University of Washington Cancer Consortium.
UCSF Helen Diller Family Comprehensive Cancer Center is an NCI-designated Cancer Center, affiliated with the UCSF School of Medicine and the UCSF Medical Center. It is one of 69 cancer research institutions in the United States supported by the National Cancer Institute, and one of three in Northern California. The HDFCCC integrates basic and clinical science, patient care, and population science to address prevention and early detection of cancer as well as the quality of life following diagnosis and treatment.
The Robert H. Lurie Comprehensive Cancer Centerof Northwestern University is a National Cancer Institute (NCI)-designated Comprehensive Cancer Center located on Northwestern Memorial Hospital's downtown medical campus in the Streeterville neighborhood of Chicago, Illinois, United States. One of two NCI-designated cancer centers in Illinois, Lurie Cancer Center's physicians and scientists hold faculty appointments within the Feinberg School of Medicine, Weinberg College of Arts and Sciences, McCormick School of Engineering and Applied Sciences, and other academic units across Northwestern University. Together, they bring their combined knowledge and expertise to patients at Northwestern Memorial Hospital, Ann & Robert H. Children's Hospital of Chicago, Shirley Ryan AbilityLab and the Jesse Brown VA Medical Center. Additionally, Lurie Cancer Center is a founding member of the National Comprehensive Cancer Network and a member of the Big Ten Cancer Research Consortium.