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A coordination complex is a chemical compound consisting of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents. Many metal-containing compounds, especially those that include transition metals, are coordination complexes.
Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.
Thiourea is an organosulfur compound with the formula SC(NH2)2 and the structure H2N−C(=S)−NH2. It is structurally similar to urea, except that the oxygen atom is replaced by a sulfur atom ; however, the properties of urea and thiourea differ significantly.
Rhodium(III) chloride refers to inorganic compounds with the formula RhCl3(H2O)n, where n varies from 0 to 3. These are diamagnetic solids featuring octahedral Rh(III) centres. Depending on the value of n, the material is either a dense brown solid or a soluble reddish salt. The soluble trihydrated (n = 3) salt is widely used to prepare compounds used in homogeneous catalysis, notably for the industrial production of acetic acid and hydroformylation.
Phosphorous acid (or phosphonic acid) is the compound described by the formula H3PO3. This acid is diprotic (readily ionizes two protons), not triprotic as might be suggested by this formula. Phosphorous acid is an intermediate in the preparation of other phosphorus compounds. Organic derivatives of phosphorous acid, compounds with the formula RPO3H2, are called phosphonic acids.
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trans-Dichlorodiammineplatinum(II) is the trans isomer of the coordination complex with the formula trans-PtCl2(NH3)2, sometimes called transplatin. It is a yellow solid with low solubility in water but good solubility in DMF. The existence of two isomers of PtCl2(NH3)2 led Alfred Werner to propose square planar molecular geometry. It belongs to the molecular symmetry point group D2h.
Neodymium nitride or neodymium(III) nitride is a chemical compound of neodymium and nitrogen with the formula NdN in which neodymium exhibits the +3 oxidation state and nitrogen exhibits the -3 oxidation state. It is ferromagnetic, like gadolinium(III) nitride, terbium(III) nitride and dysprosium(III) nitride. Neodymium nitride is not usually stoichiometric, and it is very hard to create pure stoichiometric neodymium nitride.
References
- ↑ The Life and Work of Nikolai Semenovich Kurnakov Archived 2015-09-24 at the Wayback Machine .
- ↑ Kurnakow, N. (1894). "Ueber Complexe Metallbasen; Erste Abhandlung". Journal für Praktische Chemie (in German). 50: 481–507. doi:10.1002/prac.18940500144.
- ↑ George B. Kauffman (1983). "Nikolaĭ Semenovich Kurnakov, the reaction (1893) and the man (1860–1941) a ninety-year retrospective view". Polyhedron. 2 (9): 855–863. doi:10.1016/S0277-5387(00)81400-X.
- ↑ Kong, Pi-Chang; Rochon, F. D. (1979). "cis- and trans-Platinum compounds of substituted pyrimidines and their products from thiourea in Kurnakov's reaction". Canadian Journal of Chemistry. 57 (5): 526–529. doi: 10.1139/v79-086 .
- ↑ Woollins, J. (1983). "The detection of trace amounts of trans-Pt(NH3)2Cl2 in the presence of cis-Pt(NH3)2Cl2. A high performance liquid chromatographic application of kurnakow's test". Polyhedron. 2 (3): 175–178. doi:10.1016/S0277-5387(00)83954-6.
- ↑ Alderden, R. A.; Hall, M. D.; Hambley, T. W. (2006). "The Discovery and Development of Cisplatin". Journal of Chemical Education. 83 (5): 728–773. Bibcode:2006JChEd..83..728A. doi:10.1021/ed083p728.