Lactate inflection point (LIP) is the exercise intensity at which the blood concentration of lactate and/or lactic acid begins to increase rapidly. [1] It is often expressed as 85% of maximum heart rate or 75% of maximum oxygen intake. [2] When exercising at or below the lactate threshold, any lactate produced by the muscles is removed by the body without it building up. [3]
The onset of blood lactate accumulation (OBLA) is often confused with the lactate threshold. With an exercise intensity higher than the threshold the lactate production exceeds the rate at which it can be broken down. The blood lactate concentration will show an increase equal to 4.0 mM; it then accumulates in the muscle and then moves to the bloodstream. [2]
Regular endurance exercise leads to adaptations in skeletal muscle which raises the threshold at which lactate levels will rise. This is mediated via activation of the protein receptor PGC-1α, which alters the isoenzyme composition of the lactate dehydrogenase (LDH) complex and decreases the activity of lactate dehydrogenase A (LDHA), while increasing the activity of lactate dehydrogenase B (LDHB). [4]
The lactate threshold is a useful measure for deciding exercise intensity for training and racing in endurance sports (e.g., long distance running, cycling, rowing, long distance swimming and cross country skiing), but varies between individuals and can be increased with training. [2]
Interval training alternates work and rest periods allowing the body to temporarily exceed the lactate threshold at a high intensity, and then recover (reduce blood-lactate). [2] This type of training uses the ATP-PC and the lactic acid system while exercising, which provides the most energy when there are short bursts of high intensity exercise followed by a recovery period. [5] Interval training can take the form of many different types of exercise and should closely replicate the movements found in the sport being trained for. [2] Interval training can be adjusted to the individual, however it is important to consider the intensity of each interval, duration or distance of each interval, length of rest/recovery, number of repetitions, frequency of training and recovery type. [2]
Fartlek and interval training are similar, the main difference being the structure of the exercise. Fartlek is a Swedish word, meaning speed play. [2] This type of training is a combination of continuous (generally aerobic) and interval training (generally anaerobic), involving consistent changes of pace/intensity throughout the session. [2]
Aerobic training will not increase lactic acid tolerance, however, it will increase the lactate threshold. [2] Anaerobic training will increase tolerance of the effects of lactic acid over time, allowing the muscles’ ability to work in the presence of increased lactic acid. Training at or slightly above the lactate threshold improves the lactic acid tolerance. [3]
Muscles are producing lactate even at rest, with resting blood lactate levels in the 1–2 mmol/L range. [6] Although the lactate threshold is defined as the point when lactic acid starts to accumulate, some testers approximate this by crossing the lactate threshold and using the point at which lactate reaches a concentration of 4 mmol/L of lactate. [3] Accurately measuring the lactate blood concentration involves taking blood samples (normally a pinprick to the finger, earlobe or thumb) during a ramp test where the exercise intensity is progressively increased. [7]
Blood samples are a popular way of measuring the lactate blood concentration, however there are many factors that may affect the sample. Every individual has a different health status, thus the results from the blood lactate response can vary from factors prior to exercise such as the glycogen status of the participant and ambient temperature. [8] “Furthermore, the lactate concentration measured may vary depending on the sampling site sweat contamination, and the accuracy of the lactate analyser.” [8] There are many factors that may give this test a false reading; it is important that an individual takes these into consideration, to receive an accurate test. [7]
The aerobic threshold (AeT or AerT) is sometimes defined equivalently to the lactate threshold (LT); as the exercise intensity at which blood lactate concentrations rise above resting levels. [8] In contrast, at the anaerobic threshold (AnT) the exercise is at an intensity beyond which blood lactate concentration is linearly related to exercise intensity, but increases with both exercise intensity and duration. [3] The blood lactate concentration at the anaerobic threshold is called the "maximum steady-state lactate concentration" (MLSS). [8]
AeT is the exercise intensity at which anaerobic energy pathways start to operate, considered to be around 65-85% of an individual's maximum heart rate. [2] Some have suggested this is where blood lactate reaches a concentration of 2 mmol/litre (at rest it is around 1). [3] The anaerobic energy system increases the ability to produce blood lactate during maximal exercise, resulting from an increased amount of glycogen stores[ clarification needed ] and glycolytic enzymes. [2]
In zone-based polarized training methodologies, LT1 is commonly used to designate the linear inflection point, often observed around blood lactate levels of 2.0 mmol/L, while LT2 is commonly used to designate the non-linear inflection point, often observed around blood lactate levels of 4.0 mmol/L.
Adenosine monophosphate deaminase deficiency type 1 or AMPD1, is a human metabolic disorder in which the body consistently lacks the enzyme AMP deaminase, in sufficient quantities. This may result in exercise intolerance, muscle pain and muscle cramping. The disease was formerly known as myoadenylate deaminase deficiency (MADD).
Lactic acid is an organic acid. It has the molecular formula C3H6O3. It is white in the solid state and it is miscible with water. When in the dissolved state, it forms a colorless solution. Production includes both artificial synthesis as well as natural sources. Lactic acid is an alpha-hydroxy acid (AHA) due to the presence of a hydroxyl group adjacent to the carboxyl group. It is used as a synthetic intermediate in many organic synthesis industries and in various biochemical industries. The conjugate base of lactic acid is called lactate (or the lactate anion). The name of the derived acyl group is lactoyl.
Anaerobic glycolysis is the transformation of glucose to lactate when limited amounts of oxygen (O2) are available. This occurs in health as in exercising and in disease as in sepsis and hemorrhagic shock. providing energy for a period ranging from 10 seconds to 2 minutes. During this time it can augment the energy produced by aerobic metabolism but is limited by the buildup of lactate. Rest eventually becomes necessary. The anaerobic glycolysis (lactic acid) system is dominant from about 10–30 seconds during a maximal effort. It produces 2 ATP molecules per glucose molecule, or about 5% of glucose's energy potential (38 ATP molecules). The speed at which ATP is produced is about 100 times that of oxidative phosphorylation.
Lactic acidosis refers to the process leading to the production of lactate by anaerobic metabolism. It increases hydrogen ion concentration tending to the state of acidemia or low pH. The result can be detected with high levels of lactate and low levels of bicarbonate. This is usually considered the result of illness but also results from strenuous exercise. The effect on pH is moderated by the presence of respiratory compensation.
Exercise physiology is the physiology of physical exercise. It is one of the allied health professions, and involves the study of the acute responses and chronic adaptations to exercise. Exercise physiologists are the highest qualified exercise professionals and utilise education, lifestyle intervention and specific forms of exercise to rehabilitate and manage acute and chronic injuries and conditions.
Tumor hypoxia is the situation where tumor cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic microenvironments in solid tumors are a result of available oxygen being consumed within 70 to 150 μm of tumor vasculature by rapidly proliferating tumor cells thus limiting the amount of oxygen available to diffuse further into the tumor tissue. In order to support continuous growth and proliferation in challenging hypoxic environments, cancer cells are found to alter their metabolism. Furthermore, hypoxia is known to change cell behavior and is associated with extracellular matrix remodeling and increased migratory and metastatic behavior.
Acidosis is a biological process producing hydrogen ions and increasing their concentration in blood or body fluids. pH is the negative log of hydrogen ion concentration and so it is decreased by a process of acidosis.
Anaerobic exercise is a type of exercise that breaks down glucose in the body without using oxygen; anaerobic means "without oxygen". This type of exercise leads to a buildup of lactic acid. In practical terms, this means that anaerobic exercise is more intense, but shorter in duration than aerobic exercise.
Strength training, also known as weight training or resistance training, involves the performance of physical exercises that are designed to improve physical strength. It is often associated with the lifting of weights. It can also incorporate a variety of training techniques such as bodyweight exercises, isometrics, and plyometrics.
High-intensity interval training (HIIT) is a training protocol alternating short periods of intense or explosive anaerobic exercise with brief recovery periods until the point of exhaustion. HIIT involves exercises performed in repeated quick bursts at maximum or near maximal effort with periods of rest or low activity between bouts. The very high level of intensity, the interval duration, and number of bouts distinguish it from aerobic (cardiovascular) activity, because the body significantly recruits anaerobic energy systems. The method thereby relies on "the anaerobic energy releasing system almost maximally".
Excess post-exercise oxygen consumption is a measurably increased rate of oxygen intake following strenuous activity. In historical contexts the term "oxygen debt" was popularized to explain or perhaps attempt to quantify anaerobic energy expenditure, particularly as regards lactic acid/lactate metabolism; in fact, the term "oxygen debt" is still widely used to this day. However, direct and indirect calorimeter experiments have definitively disproven any association of lactate metabolism as causal to an elevated oxygen uptake.
Interval training is a type of training exercise that involves a series of high-intensity workouts interspersed with rest or break periods. The high-intensity periods are typically at or close to anaerobic exercise, while the recovery periods involve activity of lower intensity. Varying the intensity of effort exercises the heart muscle, providing a cardiovascular workout, improving aerobic capacity and permitting the person to exercise for longer and/or at more intense levels.
Bioenergetic systems are metabolic processes that relate to the flow of energy in living organisms. Those processes convert energy into adenosine triphosphate (ATP), which is the form suitable for muscular activity. There are two main forms of synthesis of ATP: aerobic, which uses oxygen from the bloodstream, and anaerobic, which does not. Bioenergetics is the field of biology that studies bioenergetic systems.
Second wind is a phenomenon in endurance sports, such as marathons or road running, whereby an athlete who is out of breath and too tired to continue, finds the strength to press on at top performance with less exertion. The feeling may be similar to that of a "runner's high", the most obvious difference being that the runner's high occurs after the race is over. In muscle glycogenoses, an inborn error of carbohydrate metabolism impairs either the formation or utilization of muscle glycogen. As such, those with muscle glycogenoses do not need to do prolonged exercise to experience "hitting the wall". Instead, signs of exercise intolerance, such as an inappropriate rapid heart rate response to exercise, are experienced from the beginning of an activity, and some muscle GSDs can achieve second wind within about 10 minutes from the beginning of the aerobic activity, such as walking. (See below in pathology).
Lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells. LDH catalyzes the conversion of pyruvate to lactate and back, as it converts NAD+ to NADH and back. A dehydrogenase is an enzyme that transfers a hydride from one molecule to another.
Glycine propionyl-L-carnitine (GPLC) is a propionyl ester of carnitine that includes an additional glycine component. Due to tissues esterases enzymes, GPLC should act as a prodrug and lead to glycine, carnitine and propionic acid in the body.
The lactate shuttle hypothesis describes the movement of lactate intracellularly and intercellularly. The hypothesis is based on the observation that lactate is formed and utilized continuously in diverse cells under both anaerobic and aerobic conditions. Further, lactate produced at sites with high rates of glycolysis and glycogenolysis can be shuttled to adjacent or remote sites including heart or skeletal muscles where the lactate can be used as a gluconeogenic precursor or substrate for oxidation. The hypothesis was proposed in 1985 by George Brooks of the University of California at Berkeley.
Hypoventilation training is a physical training method in which periods of exercise with reduced breathing frequency are interspersed with periods with normal breathing. The hypoventilation technique consists of short breath holdings and can be performed in different types of exercise: running, cycling, swimming, rowing, skating, etc.
In kinesiology, the ventilatory threshold (VT1) refers to the point during exercise at which the volume of air breathed out (expiratory ventilation) starts to increase at an exponentially greater rate than VO2 (breath-by-breath volume of oxygen (O2)). VT1 is thought to reflect a person's anaerobic threshold — the point at which the oxygen supplied to the muscles no longer meets its oxygen requirements at a given work rate — and therefore lactate threshold — the point at which lactate begins to accumulate in the blood, because with ongoing dependence on anaerobic glycolysis, increasing amounts of CO2 need to be exhaled to accommodate its production during the conversion of lactic acid to lactate.
The physiology of marathons is typically associated with high demands on a marathon runner's cardiovascular system and their locomotor system. The marathon was conceived centuries ago and as of recent has been gaining popularity among many populations around the world. The 42.195 km distance is a physical challenge that entails distinct features of an individual's energy metabolism. Marathon runners finish at different times because of individual physiological characteristics.