Type | Charity Commission for England and Wales |
---|---|
Industry | Life science medical research charity |
Founded | 2000 |
Fate | Renamed LifeArc in 2017 |
Headquarters | , |
Number of locations | London, Stevenage, Edinburgh |
Key people |
|
Services | IP management, drug discovery, diagnostics development, antibody engineering, charity portfolio review |
Revenue |
|
Number of employees | 180 |
Website | lifearc |
LifeArc is a British life science medical research charity. [1] It was established in 2000 as MRC Technology to translate the work of UK Medical Research Council (MRC) research scientists. [2]
Today, LifeArc provides intellectual property identification, protection and commercialisation, technology development, diagnostic development, early stage drug discovery and antibody humanization services for the MRC, academia, biotechnology and pharmaceutical organisations and charities, aiming to move promising medical research forward into viable and accessible patient treatments. Profits from LifeArc's activities are reinvested into further research.
LifeArc uses funds from royalty payments to provide grants into rare disease research and allocates seed funding to UK companies.
LifeArc started as the Medical Research Council Liaison Office in 1984, and in 1986 the MRC Collaborative Centre, a laboratory-based technology transfer function, was founded. In 1993, the Liaison Office became MRC's Technology Transfer Group, responsible for office based patenting and licensing.
The organisation was set up as a charity and a company limited by guarantee in 2000 to incorporate patenting, licensing and research functions. [3]
On 15 June 2017, it officially became LifeArc. [4]
LifeArc humanised a number of antibodies on behalf of other organisations. Four of these, Tysabri (Biogen Idec/Elan), Actemra (Hoffmann-La Roche/Chugai), Entyvio (Millenium Pharma/Takeda) and Keytruda (Merck/MSD), are licensed drugs. [5]
In 2010, LifeArc signed a deal with the drug company AstraZeneca to share chemical compounds to help identify potential treatments for serious diseases. [6] [7]
LifeArc is a member of a Global Drug Discovery Alliance along with the Centre for Drug Research and Development, the Scripps Research Institute, Cancer Research Technology, the Lead Discovery Centre and the Centre for Drug Design and Discovery, dedicated to translating health research into new medicines and working together to improve the conversion of global early-stage research into much-needed new therapies. [8] Through its earnings from licensing agreements, LifeArc provides funding for academic research and early-stage medical research. [9]
Dementia Consortium was launched in December 2013: £3m drug discovery collaboration between Alzheimer's Research UK, LifeArc and pharmaceutical companies Eisai and Lilly. [10]
In March 2019, LifeArc joined with Cancer Research UK and Ono Pharma to progress new immunotherapy drug targets for cancer. [11]
In May 2019, LifeArc announced it had sold part of its royalty rights for Keytruda to a subsidiary of Canada Pension Plan Investment Board (CPPIB) for US$1.297 billion, making it one of the biggest UK medical charities by size of investment. [12]
In 2021, LifeArc launched a new strategy and a commitment to invest up to £1.3 billion by 2030 in life science research. [13] At the same time, the charity announced a new approach for treating Alzheimer's disease, a result of a partnership with the Universities of Leicester and Göttingen. [14]
An orphan drug is a pharmaceutical agent that is developed to treat certain rare medical conditions. An orphan drug would not be profitable to produce without government assistance, due to the small population of patients affected by the conditions. The conditions that orphan drugs are used to treat are referred to as orphan diseases. The assignment of orphan status to a disease and to drugs developed to treat it is a matter of public policy that depends on the legislation of the country.
AstraZeneca plc is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, England. It has a portfolio of products for major diseases in areas including oncology, cardiovascular, gastrointestinal, infection, neuroscience, respiratory, and inflammation. It has been involved in developing the Oxford–AstraZeneca COVID-19 vaccine.
Sir Gregory Paul Winter is a Nobel Prize-winning English molecular biologist best known for his work on the therapeutic use of monoclonal antibodies. His research career has been based almost entirely at the MRC Laboratory of Molecular Biology and the MRC Centre for Protein Engineering, in Cambridge, England.
MedImmune, LLC was a wholly owned subsidiary of AstraZeneca before February 14, 2019, when it was announced that the MedImmune name and branding would be discontinued in favor of AstraZeneca.
The Cambridge Biomedical Campus is the largest centre of medical research and health science in Europe. The site is located at the southern end of Hills Road in Cambridge, England.
Tremelimumab, sold under the brand name Imjudo, is a fully human monoclonal antibody used for the treatment of hepatocellular carcinoma. Tremelimumab is designed to attach to and block CTLA-4, a protein that controls the activity of T cells, which are part of the immune system.
Sir Menelaos (Mene) Nicolas Pangalos is a British neuroscientist of Greek descent.
WuXi AppTec is a global pharmaceutical, biopharmaceutical, and medical device company.
Cambridge Antibody Technology was a biotechnology company headquartered in Cambridge, England, United Kingdom. Its core focus was on antibody therapeutics, primarily using Phage Display and Ribosome Display technology.
The pharmaceutical industry in the United Kingdom directly employs around 73,000 people and in 2007 contributed £8.4 billion to the UK's GDP and invested a total of £3.9 billion in research and development. In 2007 exports of pharmaceutical products from the UK totalled £14.6 billion, creating a trade surplus in pharmaceutical products of £4.3 billion.
Merck & Co., Inc. is an American multinational pharmaceutical company headquartered in Rahway, New Jersey, and is named for Merck Group, founded in Germany in 1668, of whom it was once the American arm. The company does business as Merck Sharp & Dohme or MSD outside the United States and Canada. It is one of the largest pharmaceutical companies in the world, generally ranking in the global top five by revenue.
Brodalumab, sold under the brand name Siliq in the US and Kyntheum in the EU, is a human monoclonal antibody designed for the treatment of inflammatory diseases.
Moxetumomab pasudotox, sold under the brand name Lumoxiti, is an anti-CD22 immunotoxin medication for the treatment of adults with relapsed or refractory hairy cell leukemia (HCL) who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog. Moxetumomab pasudotox is a CD22-directed cytotoxin and is the first of this type of treatment for adults with HCL. The drug consists of the binding fragment (Fv) of an anti-CD22 antibody fused to a toxin called PE38. This toxin is a 38 kDa fragment of Pseudomonas exotoxin A.
Tralokinumab sold under the brand names Adtralza (EU/UK) and Adbry (US) among others, is a human monoclonal antibody used for the treatment of atopic dermatitis. Tralokinumab targets the cytokine interleukin 13.
Compugen Ltd. is a clinical-stage publicly traded predictive drug discovery and development company headquartered in Israel, with shares traded on the NASDAQ Capital Market and on the Tel Aviv Stock Exchange. Compugen was established as computational drug discovery service provider in 1993. Compugen originally acted as service provider for pharma companies, supplying its software and computational services to predict different types of biological phenomena. It had arrangements with big companies such as Novartis AG, Abbot Laboratories and Pfizer Inc. Subsequently, Compugen made a decision to become a drug development company with its own internal pipeline, and in 2010, decided to a focus on oncology and immunology. OncoMed Pharmaceuticals and Five Prime Therapeutics are among Compugen's competitors.
AbbVie Inc. is an American pharmaceutical company headquartered in North Chicago, Illinois. It is ranked 6th on the list of largest biomedical companies by revenue. The company's primary product is Humira (adalimumab), administered via injection. It is approved to treat autoimmune diseases including rheumatoid arthritis, Crohn's disease, plaque psoriasis, and ulcerative colitis.
Sir Stephen Philip Jackson, FRS, FMedSci is the Frederick James Quick Professor of Biology. He is a senior group leader at the Cancer Research UK Cambridge Institute and associate group leader at the Gurdon Institute, University of Cambridge.
Optimer ligands are short synthetic oligonucleotide molecules composed of DNA or RNA that bind to a specific target molecule. They are engineered to bind their target molecules with affinity typically in the low nanomolar range. Optimers can be used as antibody mimetics in a range of applications, and have been optimized to increase their stability, reduce their molecular weight, and offer increased scalability and consistency in manufacture compared to standard aptamer molecules.
Gregory James Hannon is a professor of molecular cancer biology and director of the Cancer Research UK Cambridge Institute at the University of Cambridge. He is a Fellow of Trinity College, Cambridge while also serving as a director of cancer genomics at the New York Genome Center and an adjunct professor at Cold Spring Harbor Laboratory.
Jane Osbourn, OBE, is a scientist and former chair of the UK BioIndustry Association.