Notable people of Afro-Guyanese descent
- Deborah Cox, Canadian R&B singer-songwriter with longest-running #1 R&B track on charts
- Jason David, Canadian-born American football cornerback
- JDiggz, Canadian rapper, Afro-Guyanese mother
- Melanie Fiona, Canadian R&B singer-songwriter, who is also of Indo-Guyanese descent
- Nubya Garcia, English saxophonist and jazz musician, Guyanese mother
- David Lammy, British-born politician and lawyer
- Tessa McWatt, Guyanese-born Canadian writer
- Des'ree, English singer, Afro-Guyanese mother
- Sonnet L'Abbé, Canadian writer
- Yolanda T. Marshall, Guyanese-born Canadian writer
- Dawnn Lewis, American actress
- Leona Lewis, singer and the first winner of "The X Factor" (series 3), Guyanese father
- Jermain Jackman, singer and "The Voice UK" (2015) winner
- Derek Luke, American actor
- Maestro, Canadian rapper and actor
- Nicole Narain, Playboy model, has an Afro-Guyanese mother and her father, who is of mixed Indo-Guyanese and Chinese-Guyanese descent
- Trevor Phillips, British politician
- CCH Pounder, Guyanese-born American actress
- Joy Reid, American news correspondent for MSNBC, Afro-Guyanese mother
- Rihanna, Barbados-born singer/billionaire, Afro-Guyanese mother
- Saukrates, Canadian rapper/singer
- Eon Sinclair, bassist of Canadian rock/ska/reggae band Bedouin Soundclash
- Sean Patrick Thomas, actor (Save the Last Dance and Barbershop)
- Phil Lynott, English-born frontman of the Irish rock band Thin Lizzy, Afro-Guyanese father
- Wretch 32, British rapper, Guyanese mother
- Vanessa Lee Chester, former American child actress ("A Little Princess", "Harriet the Spy", and "The Lost World: Jurassic Park")
- Letitia Wright, actress, who is best-known for playing Shuri in the 2018 film version of "Black Panther" and the 2022 sequel "Black Panther: Wakanda Forever"
- Roy Woods, Canadian R&B artist
- Saint JHN, Guyanese-American rapper
- Shaunette Renée Wilson, Guyanese-born American actress ("The Resident", "Billions", and "Black Panther")
