This is a list of the U.S. Billboard magazine Mainstream Top 40 number-one songs of 2000.
During 2000, a total of 14 singles hit number-one on the charts, with 'N Sync's "Bye Bye Bye" being the longest-running number-one single of the year, leading the chart for ten weeks.
| The best-performing song of 2000, "Everything You Want" by Vertical Horizon, never reached #1 on the weekly charts. [1] |
| Issue date | Song | Artist(s) | Reference |
|---|---|---|---|
| January 1 | "Smooth" | Santana featuring Rob Thomas | [2] |
| January 8 | "I Knew I Loved You" | Savage Garden | [3] |
| January 15 | [4] | ||
| January 22 | [5] | ||
| January 29 | [6] | ||
| February 5 | [7] | ||
| February 12 | "What a Girl Wants" | Christina Aguilera | [8] |
| February 19 | [9] | ||
| February 26 | "Show Me The Meaning of Being Lonely" | Backstreet Boys | [10] |
| March 4 | "Bye Bye Bye" | NSYNC | [11] |
| March 11 | [12] | ||
| March 18 | [13] | ||
| March 25 | [14] | ||
| April 1 | [15] | ||
| April 8 | [16] | ||
| April 15 | [17] | ||
| April 22 | [18] | ||
| April 29 | [19] | ||
| May 6 | [20] | ||
| May 13 | "I Try" | Macy Gray | [21] |
| May 20 | [22] | ||
| May 27 | [23] | ||
| June 3 | [24] | ||
| June 10 | "Oops!... I Did It Again" | Britney Spears | [25] |
| June 17 | [26] | ||
| June 24 | [27] | ||
| July 1 | "It's Gonna Be Me" | NSYNC | [28] |
| July 8 | [29] | ||
| July 15 | [30] | ||
| July 22 | [31] | ||
| July 29 | [32] | ||
| August 5 | "Bent" | Matchbox 20 | [33] |
| August 12 | "Absolutely (Story of a Girl)" | Nine Days | [34] |
| August 19 | "Bent" | Matchbox 20 | [35] |
| August 26 | [36] | ||
| September 2 | "Jumpin' Jumpin'" | Destiny's Child | [37] |
| September 9 | [38] | ||
| September 16 | [39] | ||
| September 23 | [40] | ||
| September 30 | "Kryptonite" | 3 Doors Down | [41] |
| October 7 | [42] | ||
| October 14 | [43] | ||
| October 21 | [44] | ||
| October 28 | "With Arms Wide Open" | Creed | [45] |
| November 4 | "Kryptonite" | 3 Doors Down | [46] |
| November 11 | "With Arms Wide Open" | Creed | [47] |
| November 18 | [48] | ||
| November 25 | [49] | ||
| December 2 | [50] | ||
| December 9 | "Independent Women Part I" | Destiny's Child | [51] |
| December 16 | [52] | ||
| December 23 | [53] | ||
| December 30 | [54] |