This is a list of songs which reached number one on the Billboard Mainstream Top 40 (or Pop Songs) chart in 2010.
During 2010, a total of 17 singles hit number-one on the charts.
| Indicates best-performing single of 2010 |
| Issue date | Song | Artist(s) | Ref. |
|---|---|---|---|
| January 2 | "Replay" | Iyaz | [1] |
| January 9 | [2] | ||
| January 16 | "Bad Romance" | Lady Gaga | [3] |
| January 23 | [4] | ||
| January 30 | [5] | ||
| February 6 | "Tik Tok" | Ke$ha | [6] |
| February 13 | [7] | ||
| February 20 | [8] | ||
| February 27 | [9] | ||
| March 6 | [10] | ||
| March 13 | [11] | ||
| March 20 | [12] | ||
| March 27 | "Telephone" | Lady Gaga featuring Beyoncé | [13] |
| April 3 | [14] | ||
| April 10 | [15] | ||
| April 17 | [16] | ||
| April 24 | "In My Head" | Jason Derülo | [17] |
| May 1 | [18] | ||
| May 8 | "Rude Boy" | Rihanna | [19] |
| May 15 | [20] | ||
| May 22 | "Nothin' on You" | B.o.B featuring Bruno Mars | [21] |
| May 29 | "Break Your Heart" | Taio Cruz featuring Ludacris | [22] |
| June 5 | [23] | ||
| June 12 | [24] | ||
| June 19 | "Your Love Is My Drug" | Ke$ha | [25] |
| June 26 | [26] | ||
| July 3 | "California Gurls" | Katy Perry featuring Snoop Dogg | [27] |
| July 10 | [28] | ||
| July 17 | [29] | ||
| July 24 | [30] | ||
| July 31 | [31] | ||
| August 7 | [32] | ||
| August 14 | [33] | ||
| August 21 | "Love the Way You Lie" | Eminem featuring Rihanna | [34] |
| August 28 | [35] | ||
| September 4 | "Dynamite" | Taio Cruz | [36] |
| September 11 | [37] | ||
| September 18 | [38] | ||
| September 25 | [39] | ||
| October 2 | "Teenage Dream" | Katy Perry | [40] |
| October 9 | [41] | ||
| October 16 | [42] | ||
| October 23 | [43] | ||
| October 30 | "Just the Way You Are" | Bruno Mars | [44] |
| November 6 | [45] | ||
| November 13 | [46] | ||
| November 20 | "Just a Dream" | Nelly | [47] |
| November 27 | [48] | ||
| December 4 | "Only Girl (In the World)" | Rihanna | [49] |
| December 11 | [50] | ||
| December 18 | [51] | ||
| December 25 | "Raise Your Glass" | P!nk | [52] |
Strange Music is an American independent record label founded by Tech N9ne and Travis O'Guin in 1999, specializing in hip hop music. It is currently distributed through Fontana Distribution.