This is a list of Columbia Lions football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1936 | 6 | 1 | 46 | Al Barabas | Philadelphia Eagles | B |
| 1939 | 1 | 2 | 2 | Sid Luckman | Chicago Bears | QB |
| 17 | 5 | 155 | John Siegal | Brooklyn Dodgers | E | |
| 1942 | 11 | 1 | 91 | Thornley Wood | Pittsburgh Steelers | B |
| 1943 | 1 | 4 | 4 | Paul Governali | Brooklyn Dodgers | B |
| 1944 | 28 | 5 | 290 | Tom Rock | New York Giants | E |
| 1946 | 12 | 1 | 101 | Vinnie Yablonski | Chicago Cardinals | B |
| 16 | 2 | 142 | Bill Swiacki | Boston Yanks | E | |
| 1948 | 4 | 1 | 24 | Bruce Gehrke | New York Giants | E |
| 22 | 1 | 196 | George Kisiday | New York Giants | T | |
| 1949 | 3 | 1 | 22 | Lou Kusserow | Detroit Lions | B |
| 3 | 3 | 24 | Bill Olson | New York Giants | B | |
| 10 | 4 | 95 | Gene Rossides | New York Giants | B | |
| 1967 | 16 | 8 | 401 | Jerry Zawadzkas | Detroit Lions | TE |
| 1969 | 1 | 9 | 9 | Marty Domres | San Diego Chargers | QB |
| 1971 | 11 | 12 | 272 | George Starke | Washington Redskins | T |
| 1984 | 6 | 20 | 160 | John Witkowski | Detroit Lions | QB |
| 1997 | 2 | 22 | 52 | Marcellus Wiley | Buffalo Bills | DE |