This is a list of the Official Charts Company's UK R&B Chart number-one singles of 2010.
| † | Best-selling R&B single of the year |
| Issue date | Single | Artist(s) |
|---|---|---|
| 9 January [1] | "Meet Me Halfway" | The Black Eyed Peas |
| 16 January [2] | "Replay" | Iyaz |
| 23 January [3] | ||
| 30 January [4] | ||
| 6 February [5] | ||
| 13 February [6] | ||
| 20 February [7] | ||
| 27 February [8] | "Rude Boy" | Rihanna |
| 6 March [9] | "In My Head" | Jason Derülo |
| 13 March [10] | "Pass Out" | Tinie Tempah |
| 20 March [11] | ||
| 27 March [12] | ||
| 3 April [13] | ||
| 10 April [14] | "She Said" | Plan B |
| 17 April [15] | "OMG" | Usher featuring will.i.am |
| 24 April [16] | ||
| 1 May [17] | ||
| 8 May [18] | ||
| 15 May [19] | ||
| 22 May [20] | "Ridin' Solo" | Jason Derülo |
| 29 May [21] | "Nothin' on You" | B.o.B featuring Bruno Mars |
| 5 June [22] | "Dirtee Disco" | Dizzee Rascal |
| 12 June [23] | "Nothin' on You" | B.o.B featuring Bruno Mars |
| 19 June [24] | "Frisky" | Tinie Tempah featuring Labrinth |
| 26 June [25] | "Wavin' Flag (The Celebration Mix)" | K'naan |
| 3 July [26] | ||
| 10 July [27] | "Airplanes" | B.o.B featuring Hayley Williams |
| 17 July [28] | "The Club Is Alive" | JLS |
| 24 July [29] | "Airplanes" | B.o.B featuring Hayley Williams |
| 31 July [30] | "Love the Way You Lie" † | Eminem featuring Rihanna |
| 7 August [31] | "Billionaire" | Travie McCoy featuring Bruno Mars |
| 14 August [32] | "Beautiful Monster" | Ne-Yo |
| 21 August [33] | "Love the Way You Lie" † | Eminem featuring Rihanna |
| 28 August [34] | "Green Light" | Roll Deep |
| 4 September [35] | "Dynamite" | Taio Cruz |
| 11 September [36] | ||
| 18 September [37] | ||
| 25 September [38] | ||
| 2 October [39] | ||
| 9 October [40] | "Written in the Stars" | Tinie Tempah featuring Eric Turner |
| 16 October [41] | "Forget You" | Cee Lo Green |
| 23 October [42] | ||
| 30 October [43] | ||
| 6 November [44] | ||
| 13 November [45] | ||
| 20 November [46] | ||
| 27 November [47] | "Like a G6" | Far East Movement featuring Cataracs and Dev |
| 4 December [48] | ||
| 11 December [49] | ||
| 18 December [50] | "Whip My Hair" | Willow Smith |
| 25 December [51] | "What's My Name" | Rihanna featuring Drake |
| Position | Artist | Weeks at number one |
|---|---|---|
| 1 | Cee Lo Green | 6 |
| 1 | Iyaz | 6 |
| 1 | Tinie Tempah | 6 |
| 4 | will.i.am | 5 |
| 4 | Taio Cruz | 5 |
| 4 | Usher | 5 |
| 8 | B.o.B | 4 |
| 4 | Rihanna | 4 |
| 9 | Bruno Mars | 3 |
| 9 | Far East Movement | 3 |
| 11 | K'Naan | 2 |
