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The Zapotec culture is polytheist. Notable deities include:
- Cocijo, god of rain
- Coquihani, god of light
- Cozobi, god of maize
- Huetexi Pea, god who measured the world
- Cozaana, god who created animals and fish, god of the hunt,creator deity and consort of Huichaana
- Huichaana, goddess who created men and fish, goddess of procreation and children, creator deity and consort of Cozaana
- Copiycha, god of the sun
- Pezeelao, god of the hereafter
- Xoo, god of earthquakes
- Peeze, god of omens
- Paa, god of merchants, wealth, good fortune, and happiness
- Ziy, god of misery and misfortune
- Xicala, god of dreams
- Pecala, god of love and lechery [1]