List of adverse effects of lurasidone

This is a list of adverse effects of the antipsychotic drug lurasidone, sorted by frequency of occurrence. ^{[1] [2] [3]}

Very common

Very common (>10% incidence) adverse effects include:

• Somnolence ^† (produces an intermediate degree of sedation compared to other atypical antipsychotics ^[4] )
• Akathisia ^†
• Fasting glucose increased^†
• Nausea^†
• Parkinsonism ^†
• Insomnia^†

^† These are dose-dependent.

Common

Common (1–10% incidence) adverse effects include:

• Vomiting^†
• Dyspepsia ^†
• Agitation^†
• Anxiety^†
• Dystonia
• Dizziness^†
• Fatigue
• Back pain^†
• Restlessness
• Hypersalivation ^†
• Weight gain^{† [5]}

^† These are dose-dependent.

Uncommon

Uncommon (0.1–1% incidence) adverse effects include:

• Orthostatic hypotension
• Syncope
• Stroke
• Seizure
• Suicidal ideation
• Elevated serum creatinine

Rare

Rare (<0.01% incidence) adverse effects include:

• Agranulocytosis
• Leukopaenia
• Neutropaenia
• Tardive dyskinesia
• Neuroleptic malignant syndrome

Unknown frequency

Unknown frequency adverse effects include:

• Transient ischaemic attack
• Hyperprolactinaemia (seems to be a rather prominent adverse effect according to a meta-analysis ^[4] )
• Hypothermia

References

1. Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013.
2. lurasidone (Rx) - Latuda [Internet]. Medscape Reference. [cited 2013 Oct 1]. Available from: http://reference.medscape.com/drug/latuda-lurasidone-999605#4
3. LATUDA (lurasidone hydrochloride) tablet, film coated [Bushu Pharmaceutical, LTD.] [Internet]. DailyMed. 2010 [cited 2013 Oct 1]. Available from: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=88a244d1-eddb-499c-bee2-e1f49056e78f
4. Leucht, S; Cipriani, A; Spineli, L; Mavridis, D; Orey, D; Richter, F; Samara, M; Barbui, C; Engel, RR; Geddes, JR; Kissling, W; Stapf, MP; Lässig, B; Salanti, G; Davis, JM (September 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis". Lancet. 382 (9896): 951–962. doi:10.1016/S0140-6736(13)60733-3. PMID   23810019. S2CID   32085212.
5. Ketter, T. A; Sarma, K; Silva, R; Kroger, H; Cucchiaro, J; Loebel, A (2016-02-26). "Lurasidone in the Long-Term Treatment of Patients with Bipolar Disorder: A 24-Week Open-Label Extension Study". Depression and Anxiety. 33 (5): 424–434. doi:10.1002/da.22479. PMC   5069590 . PMID   26918425.