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A cleft lip contains an opening in the upper lip that may extend into the nose. The opening may be on one side, both sides, or in the middle. A cleft palate occurs when the palate contains an opening into the nose. The term orofacial cleft refers to either condition or to both occurring together. These disorders can result in feeding problems, speech problems, hearing problems, and frequent ear infections. Less than half the time the condition is associated with other disorders.
The hard palate is a thin horizontal bony plate made up of two bones of the facial skeleton, located in the roof of the mouth. The bones are the palatine process of the maxilla and the horizontal plate of palatine bone. The hard palate spans the alveolar arch formed by the alveolar process that holds the upper teeth.
Van der Woude syndrome (VDWS) is a genetic disorder characterized by the combination of lower lip pits, cleft lip with or without cleft palate (CL/P), and cleft palate only (CPO). The frequency of orofacial clefts ranges from 1:1000 to 1:500 births worldwide, and there are more than 400 syndromes that involve CL/P. VWS is distinct from other clefting syndromes due to the combination of cleft lip and palate (CLP) and CPO within the same family. Other features frequently associated with VWS include hypodontia in 10-81% of cases, narrow arched palate, congenital heart disease, heart murmur and cerebral abnormalities, syndactyly of the hands, polythelia, ankyloglossia, and adhesions between the upper and lower gum pads.
Operation Smile is a nonprofit medical service organization founded in 1982 by William P. Magee Jr. and his wife Kathleen (Kathy) S. Magee. It is headquartered in Virginia Beach, Virginia.
Smile Train is a nonprofit organization and charity providing corrective surgery for children with cleft lips and palates. Headquartered in New York City and founded in 1999, Smile Train provides free corrective cleft surgery in 87 countries, training local doctors and providing hospital funding for the procedures.
Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by the IRF6 gene.
ReSurge International, formerly known as Interplast, is an international humanitarian organization that provides free reconstructive surgery in developing countries, primarily to children with cleft lip and palate and burn scar contractures.
Cleft lip and/or palate is a congenital abnormality that is seen frequently around the world. On average, about 1 in every 500-750 live births result in a cleft. Furthermore, in the U.S., the prevalence for cleft lip with or without cleft palate is 2.2 to 11.7 per 10,000 births. Cleft palate alone (CP) results in a prevalence rate of 5.5 to 6.6 per 10,000 births. Cleft of the lip, palate, or both is one of the most common congenital abnormalities and has a birth prevalence rate ranging from 1/1000 to 2.69/1000 amongst different parts of the world.
Smile Network International is an American non-profit, humanitarian organization that specializes in providing free surgeries for impoverished children in developing countries who are born with cleft lips and palates.
PHD finger protein 8 is a protein that in humans is encoded by the PHF8 gene.
A jaw abnormality is a disorder in the formation, shape and/or size of the jaw. In general abnormalities arise within the jaw when there is a disturbance or fault in the fusion of the mandibular processes. The mandible in particular has the most differential typical growth anomalies than any other bone in the human skeleton. This is due to variants in the complex symmetrical growth pattern which formulates the mandible.
S. M. Balaji is a dental, oral, and maxillofacial surgeon from Chennai, Tamil Nadu, India, who specializes in repair of cleft palate, rhinoplasty, ear reconstruction, jaw reconstruction, facial asymmetry correction, dental implantology, maxillofacial surgery and Craniofacial surgery. He is an alumnus of Annamalai University.
Maxillary hypoplasia, or maxillary deficiency, is an underdevelopment of the bones of the upper jaw. It is associated with Crouzon syndrome, Angelman syndrome, as well as Fetal alcohol syndrome. It can also be associated with Cleft lip and cleft palate. Some people could develop it due to poor dental extractions.
A facial cleft is an opening or gap in the face, or a malformation of a part of the face. Facial clefts is a collective term for all sorts of clefts. All structures like bone, soft tissue, skin etc. can be affected. Facial clefts are extremely rare congenital anomalies. There are many variations of a type of clefting and classifications are needed to describe and classify all types of clefting. Facial clefts hardly ever occur isolated; most of the time there is an overlap of adjacent facial clefts.
Ameeksha Dilchand; is a Mauritian beauty pageant titleholder who was crowned Miss Mauritius 2012. Ameeksha attended the Notre Dame de la Confiance RCA school for her primary education then joined the Loreto College of Rose-Hill for her secondary studies. Ameeksha completed her LLB(hons) from University College London (UCL).
Operation Smile China Medical Mission (OSCMM) is a non-profit organisation that provides reconstructive surgery for the underprivileged children with cleft lips and / or palates in China.
The Overseas Plastic Surgery Appeal is a registered charity in the UK, that exists to provide free facial surgery for poor children and young adults in Pakistan. The OPSA team operate on facial abnormalities including cleft lip and palate.
Alliance for Smiles (AfS) is a nonprofit organization founded in 2004 in San Francisco. They provide free surgical repairs for cleft lip and cleft palate, with missions mostly in the continents of Asia and Africa. They also work to develop treatment centers where continuous follow-up care can be provided.
Hirji Sorab Adenwalla was an Indian missionary who joined the Jubilee Mission in Kerala, India, as a surgeon. Adenwalla turned what was originally a small dispensary into a 1500-bedded medical college and research institute called the Jubilee Mission Medical College. Adenwalla specialized in cleft lip and cleft palate surgeries, providing treatment at low or no cost to more than 21,000 patients. Adenwalla contributed several new techniques to the cleft lip surgery, such as a method to avoid a vermillion notch, a protocol for cleft lip nose correction in unilateral cleft lips, and a procedure for septal repositioning.
Global Smile Foundation (GSF) is a nonprofit organization headquartered in Norwood, Massachusetts, U.S., dedicated to providing free comprehensive cleft care, including surgery and dental services, to children in underserved regions of the global south. Additionally, the foundation offers education and training for healthcare providers specializing in cleft treatment.