This is a list of the Spanish PROMUSICAE Top 20 Singles number-ones of 2001. [1]
| Issue Date | Song | Artist |
|---|---|---|
| 1 January | No cambié | Tamara |
| 8 January | Love Don't Cost a Thing | Jennifer Lopez |
| 15 January | ||
| 22 January | ||
| 29 January | La otra orilla (Un pueblo) | Reincidentes |
| 5 February | ||
| 12 February | ||
| 19 February | ||
| 26 February | Carnavalito | King África |
| 5 March | ||
| 12 March | ||
| 19 March | ||
| 26 March | ||
| 2 April | Club Tropicana | Gypsy Teens |
| 9 April | ||
| 16 April | What It Feels Like for a Girl | Madonna |
| 23 April | Dream On | Depeche Mode |
| 30 April | ||
| 7 May | ||
| 14 May | Me gustas tú | Manu Chao |
| 21 May | ||
| 28 May | ||
| 4 June | ||
| 11 June | Prohibida | Raúl |
| 18 June | ||
| 25 June | ||
| 2 July | ||
| 9 July | ||
| 16 July | El baile del gorila | Melody |
| 23 July | Lady Marmalade | Christina Aguilera, Lil' Kim, Mýa & Pink featuring Missy Elliott |
| 30 July | ||
| 6 August | Hidden Place | Björk |
| 13 August | Little L | Jamiroquai |
| 20 August | ||
| 27 August | ||
| 3 September | ||
| 10 September | It Began in Afrika | The Chemical Brothers |
| 17 September | ||
| 24 September | Can't Get You Out of My Head | Kylie Minogue |
| 1 October | ||
| 8 October | You Rock My World | Michael Jackson |
| 15 October | Hero | Enrique Iglesias |
| 22 October | Partiendo la pana | Estopa |
| 29 October | Suerte | Shakira |
| 5 November | Gracias Por La Música | Academia Operacion Triunfo Gala 1 |
| 12 November | Lady Marmalade | Academia Operacion Triunfo Gala 2 |
| 19 November | Can't Get You Out of My Head | Kylie Minogue |
| 26 November | ||
| 3 December | ||
| 10 December | And Then There Was Silence | Blind Guardian |
| 17 December | ||
| 24 December | Can't Get You Out of My Head | Kylie Minogue |
| 31 December | Abre tu sonrisa | Sugarless |
Greatest Hits Vol. II is the third English greatest hits album released by American singer Gloria Estefan, but is the fourth compilation and twenty-third album overall, released in 2001.