MIR194-1

MIR194-1
Identifiers
Aliases	MIR194-1 , MIRN194-1, mir-194-1, microRNA 194-1
External IDs	OMIM: 610940 GeneCards: MIR194-1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q41 Start 220,118,157 bp [1] End 220,118,241 bp [1]
RNA expression pattern Bgee Top expressed in lung kidney heart stomach Achilles tendon colon adrenal gland More reference expression data BioGPS n/a
Orthologs
Species	Human	Mouse
Entrez	406969	n/a
Ensembl	ENSG00000207624	n/a
UniProt	n a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 1: 220.12 – 220.12 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene. ^[3]

Function

microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. ^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000207624 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: MicroRNA 194-1" . Retrieved 2014-05-29.

Further reading

• Sundaram P, Hultine S, Smith LM, Dews M, Fox JL, Biyashev D, Schelter JM, Huang Q, Cleary MA, Volpert OV, Thomas-Tikhonenko A (Dec 2011). "p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers". Cancer Research. 71 (24): 7490–7501. doi:10.1158/0008-5472.CAN-11-1124. PMC   3242824 . PMID   22028325.
• Dong P, Kaneuchi M, Watari H, Hamada J, Sudo S, Ju J, Sakuragi N (2011). "MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1". Molecular Cancer. 10: 99. doi:10.1186/1476-4598-10-99. PMC   3173388 . PMID   21851624.
• Song Y, Zhao F, Wang Z, Liu Z, Chiang Y, Xu Y, Gao P, Xu H (Jul 2012). "Inverse association between miR-194 expression and tumor invasion in gastric cancer". Annals of Surgical Oncology. 19 Suppl 3: S509–17. doi:10.1245/s10434-011-1999-2. PMID   21845495. S2CID   6856251.
• Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (Feb 2003). "New microRNAs from mouse and human". RNA. 9 (2): 175–179. doi:10.1261/rna.2146903. PMC   1370382 . PMID   12554859.
• Xu J, Kang Y, Liao WM, Yu L (2012). "MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5". PLOS ONE. 7 (3): e31861. Bibcode:2012PLoSO...731861X. doi: 10.1371/journal.pone.0031861 . PMC   3291608 . PMID   22396742.
• Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM (Oct 2010). "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development". Cancer Cell. 18 (4): 367–381. doi:10.1016/j.ccr.2010.09.005. PMC   3561766 . PMID   20951946.
• Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ (Oct 2003). "Reduced accumulation of specific microRNAs in colorectal neoplasia". Molecular Cancer Research. 1 (12): 882–891. PMID   14573789.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.