MIR195

MIR195
Identifiers
Aliases	MIR195 , MIRN195, miRNA195, mir-195, microRNA 195
External IDs	OMIM: 610718; GeneCards: MIR195; OMA:MIR195 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,017,701 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; thyroid gland; ; endometrium; ; blood; ; pituitary gland; ; anterior cingulate cortex; ; male reproductive system; ; testicle; ; mesencephalon; ; skin of leg;
	n/a
	More reference expression data
	n/a
Orthologs
	406971
	n/a
	ENSG00000284112
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated September 19, 2024

MicroRNA 195 is a microRNA that in humans is encoded by the MIR195 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

The miR-129 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. This microRNA was first experimentally characterised in mouse and homologues have since been discovered in several other species, such as humans, rats and zebrafish. The mature sequence is excised by the Dicer enzyme from the 5' arm of the hairpin. It was elucidated by Calin et al. that miR-129-1 is located in a fragile site region of the human genome near a specific site, FRA7H in chromosome 7q32, which is a site commonly deleted in many cancers. miR-129-2 is located in 11p11.2.

The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, miR-15, mir-195 and miR-497 are related microRNA precursor sequences from the mir-15 gene family. This microRNA family appears to be vertebrate specific and its members have been predicted or experimentally validated in a wide range of vertebrate species.

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.

In molecular biology mir-126 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several pre- and post-transcription mechanisms.

In molecular biology, miR-137 is a short non-coding RNA molecule that functions to regulate the expression levels of other genes by various mechanisms. miR-137 is located on human chromosome 1p22 and has been implicated to act as a tumor suppressor in several cancer types including colorectal cancer, squamous cell carcinoma and melanoma via cell cycle control.

In molecular biology mir-143 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir–143 is highly conserved in vertebrates. mir-143 is thought be involved in cardiac morphogenesis but has also been implicated in cancer.

In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes.

In molecular biology mir-22 microRNA is a short RNA molecule. MicroRNAs are an abundant class of molecules, approximately 22 nucleotides in length, which can post-transcriptionally regulate gene expression by binding to the 3' UTR of mRNAs expressed in a cell.

In molecular biology, mir-221 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-491 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-185 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 885 is a protein that in humans is encoded by the MIR885 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000284112 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 195" . Retrieved 2018-05-07.

Flavin RJ, Smyth PC, Laios A, O'Toole SA, Barrett C, Finn SP, Russell S, Ring M, Denning KM, Li J, Aherne ST, Sammarae DA, Aziz NA, Alhadi A, Sheppard BL, Lao K, Sheils OM, O'Leary JJ (February 2009). "Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma". Mod. Pathol. 22 (2): 197–205. doi: 10.1038/modpathol.2008.135 . PMID 18677302.
Liu L, Chen L, Xu Y, Li R, Du X (September 2010). "microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells". Biochem. Biophys. Res. Commun. 400 (2): 236–40. doi:10.1016/j.bbrc.2010.08.046. PMID 20727858.
Gonsalves C, Kalra VK (November 2010). "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195". J. Immunol. 185 (10): 6253–64. doi: 10.4049/jimmunol.1000660 . PMID 20952681.
Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q, Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L (April 2011). "Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer". Clin. Cancer Res. 17 (7): 1722–30. doi: 10.1158/1078-0432.CCR-10-1800 . PMID 21350001.
Wang X, Wang J, Ma H, Zhang J, Zhou X (June 2012). "Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer". Med. Oncol. 29 (2): 919–27. doi:10.1007/s12032-011-9880-5. PMID 21390519. S2CID 19566991.
Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N (October 2011). "Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation". J. Cell. Physiol. 226 (10): 2535–42. doi:10.1002/jcp.22598. PMID 21792910. S2CID 42464226.
Yang X, Yin J, Yu J, Xiang Q, Liu Y, Tang S, Liao D, Zhu B, Zu X, Tang H, Lei X (January 2012). "miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w". Oncol. Rep. 27 (1): 250–7. doi: 10.3892/or.2011.1472 . PMID 21947305.
Brenner B, Hoshen MB, Purim O, David MB, Ashkenazi K, Marshak G, Kundel Y, Brenner R, Morgenstern S, Halpern M, Rosenfeld N, Chajut A, Niv Y, Kushnir M (September 2011). "MicroRNAs as a potential prognostic factor in gastric cancer". World J. Gastroenterol. 17 (35): 3976–85. doi: 10.3748/wjg.v17.i35.3976 . PMC 3199555 . PMID 22046085.
Zhang QQ, Xu H, Huang MB, Ma LM, Huang QJ, Yao Q, Zhou H, Qu LH (March 2012). "MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion". Neuro-Oncology. 14 (3): 278–87. doi:10.1093/neuonc/nor216. PMC 3280801 . PMID 22217655.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000284112 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 195" . Retrieved 2018-05-07.

[1]

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[3]

MIR195

Contents

Function

Related Research Articles

References

Further reading