MIR200C

MIR200C
Identifiers
Aliases	MIR200C , MIRN200C, mir-200c, microRNA 200c
External IDs	OMIM: 612092; GeneCards: MIR200C; OMA:MIR200C - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,963,766 bp
RNA expression pattern
	Top expressed in
	epididymis; ; placenta; ; glomerulus; ; adrenal gland; ; spleen; ; fundus; ; olfactory zone of nasal mucosa; ; monocyte; ; body of pancreas; ; islet of Langerhans;
	n/a
	More reference expression data
	n/a
Orthologs
	406985
	n/a
	ENSG00000207713
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated November 09, 2024

MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C gene. ^[3]

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

mir-8/mir-141/mir-200 microRNA precursor family

The miR-8 microRNA precursor, is a short non-coding RNA gene involved in gene regulation. miR-8 in Drosophila melanogaster is expressed from the 3' arm of related precursor hairpins, along with miR-200, miR-236, miR-429 and human and mouse homolog miR-141. Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species. The bounds of the precursors are predicted based on conservation and base pairing and are not generally known.

In molecular biology, the miR-200 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by binding and cleaving mRNAs or inhibiting translation. The miR-200 family contains miR-200a, miR-200b, miR-200c, miR-141, and miR-429. There is growing evidence to suggest that miR-200 microRNAs are involved in cancer metastasis.

In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes.

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.

MicroRNA 34a (miR-34a) is a microRNA that in humans is encoded by the MIR34A gene.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene.

MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene.

MicroRNA 494 is a microRNA sequence which is encoded in humans by the MIR494 gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

MicroRNA 195 is a microRNA that in humans is encoded by the MIR195 gene.

MicroRNA 210 is a protein that in humans is encoded by the MIR210 gene.

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene.

MicroRNA 517c is a protein that in humans is encoded by the MIR517C gene.

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000207713 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 200c" . Retrieved 2018-04-10.

Hurteau GJ, Carlson JA, Spivack SD, Brock GJ (September 2007). "Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin". Cancer Res. 67 (17): 7972–6. doi:10.1158/0008-5472.CAN-07-1058. PMID 17804704.
Hurteau GJ, Carlson JA, Roos E, Brock GJ (July 2009). "Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression". Cell Cycle. 8 (13): 2064–9. doi: 10.4161/cc.8.13.8883 . PMID 19502803.
Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, Diehn M, Liu H, Panula SP, Chiao E, Dirbas FM, Somlo G, Pera RA, Lao K, Clarke MF (August 2009). "Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells". Cell. 138 (3): 592–603. doi:10.1016/j.cell.2009.07.011. PMC 2731699 . PMID 19665978.
Sossey-Alaoui K, Bialkowska K, Plow EF (November 2009). "The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion". J. Biol. Chem. 284 (48): 33019–29. doi: 10.1074/jbc.M109.034553 . PMC 2785142 . PMID 19801681.
Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW (January 2010). "Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells". PLOS ONE. 5 (1): e8697. Bibcode:2010PLoSO...5.8697V. doi: 10.1371/journal.pone.0008697 . PMC 2805718 . PMID 20084174.
Uhlmann S, Zhang JD, Schwäger A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (July 2010). "miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer". Oncogene. 29 (30): 4297–306. doi:10.1038/onc.2010.201. PMID 20514023. S2CID 41341426.
Schickel R, Park SM, Murmann AE, Peter ME (June 2010). "miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1". Mol. Cell. 38 (6): 908–15. doi:10.1016/j.molcel.2010.05.018. PMC 2904349 . PMID 20620960.
Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, Papotti M, Allgayer H (September 2010). "Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer". Mol. Cancer Res. 8 (9): 1207–16. doi: 10.1158/1541-7786.MCR-10-0052 . PMID 20696752.
Leskelä S, Leandro-García LJ, Mendiola M, Barriuso J, Inglada-Pérez L, Muñoz I, Martínez-Delgado B, Redondo A, de Santiago J, Robledo M, Hardisson D, Rodríguez-Antona C (February 2011). "The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients". Endocr. Relat. Cancer. 18 (1): 85–95. doi: 10.1677/ERC-10-0148 . PMID 21051560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000207713 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 200c" . Retrieved 2018-04-10.

[1]

[2]

[3]

MIR200C

Contents

Function

Related Research Articles

References

Further reading