MIR3648

MIR3648-1
Identifiers
Aliases	MIR3648-1 , MIR3648, hsa-mir-3648-1, microRNA 3648-1, MicroRNA 3648
External IDs	GeneCards: MIR3648-1
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21p11.2 Start 8,208,473 bp [1] End 8,208,652 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells sural nerve thymus blood liver skeletal muscle tissue monocyte prefrontal cortex kidney right lobe of liver n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100500862 n/a Ensembl ENSG00000275708 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 21: 8.21 – 8.21 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

MicroRNA 3648 is a microRNA that in humans is produced by MIR3648 gene. This gene was recently shown to be specific to humans by Nathan H. Lents and colleagues. ^{[3] [4]}

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

1. GRCh38: Ensembl release 89: ENSG00000275708 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hunter R. Johnson; Jessica A. Blandino; Beatriz C. Mercado; José A. Galván; William J. Higgins; Nathan H. Lents (June 2022). "The evolution of de novo human-specific microRNA genes on chromosome 21". American Journal of Biological Anthropology. 178 (2): 223–243. doi:10.1002/ajpa.24504. S2CID   247240062.
4. "Entrez Gene: MicroRNA 3648" . Retrieved 2013-07-26.

Further reading

• Meiri, E.; Levy, A.; Benjamin, H.; Ben-David, M.; Cohen, L.; Dov, A.; Dromi, N.; Elyakim, E.; Yerushalmi, N.; Zion, O.; Lithwick-Yanai, G.; Sitbon, E. (2010). "Discovery of microRNAs and other small RNAs in solid tumors". Nucleic Acids Research. 38 (18): 6234–6246. doi:10.1093/nar/gkq376. PMC   2952848 . PMID   20483914.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.