MIR885 (gene)

MIR885
Identifiers
Aliases	MIR885 , MIRN885, hsa-mir-885, mir-885, microRNA 885
External IDs	GeneCards: MIR885
Orthologs
Species	Human	Mouse
Entrez	100126334	n/a
Ensembl	ENSG00000216135	n/a
UniProt	n a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata
View/Edit Human

MicroRNA 885 is a protein that in humans is encoded by the MIR885 gene. ^[2]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Entrez Gene: MicroRNA 885" . Retrieved 2018-05-18.

Further reading

• Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, Theissen J, Fischer M, Zapatka M, Brors B, Savelyeva L, Sagulenko V, Speleman F, Schwab M, Westermann F (June 2011). "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival". Cell Death Differ. 18 (6): 974–84. doi:10.1038/cdd.2010.164. PMC   3131937 . PMID   21233845.
• Huang X, Xu S, Gao J, Liu F, Yue J, Chen T, Wu B (October 2011). "miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells". Int. J. Mol. Med. 28 (4): 659–67. doi: 10.3892/ijmm.2011.721 . PMID   21687927.
• Huang Y, Chuang AY, Ratovitski EA (November 2011). "Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure". Cell Cycle. 10 (22): 3938–47. doi:10.4161/cc.10.22.18107. PMC   3266119 . PMID   22071691.
• Guan X, Liu Z, Liu H, Yu H, Wang LE, Sturgis EM, Li G, Wei Q (April 2013). "A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer". FASEB J. 27 (4): 1404–12. doi:10.1096/fj.12-223420. PMC   3606531 . PMID   23271051.
• Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S (March 2015). "Signature of circulating microRNAs in osteoarthritis" (PDF). Ann. Rheum. Dis. 74 (3): e18. doi:10.1136/annrheumdis-2013-204698. PMID   24515954.
• Xiao F, Qiu H, Cui H, Ni X, Li J, Liao W, Lu L, Ding K (April 2015). "MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling". Oncogene. 34 (15): 1968–78. doi: 10.1038/onc.2014.134 . PMID   24882581. S2CID   11424568.
• Plieskatt JL, Rinaldi G, Feng Y, Peng J, Yonglitthipagon P, Easley S, Laha T, Pairojkul C, Bhudhisawasdi V, Sripa B, Brindley PJ, Mulvenna JP, Bethony JM (October 2014). "Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumourigenic liver fluke Opisthorchis viverrini" (PDF). J. Hepatol. 61 (4): 850–8. doi:10.1016/j.jhep.2014.05.035. PMID   25017828.
• Hur K, Toiyama Y, Schetter AJ, Okugawa Y, Harris CC, Boland CR, Goel A (March 2015). "Identification of a metastasis-specific MicroRNA signature in human colorectal cancer". J. Natl. Cancer Inst. 107 (3). doi:10.1093/jnci/dju492. PMC   4334826 . PMID   25663689.
• El-Diwany R, Wasilewski LN, Witwer KW, Bailey JR, Page K, Ray SC, Cox AL, Thomas DL, Balagopal A (September 2015). "Acute Hepatitis C Virus Infection Induces Consistent Changes in Circulating MicroRNAs That Are Associated with Nonlytic Hepatocyte Release". J. Virol. 89 (18): 9454–64. doi:10.1128/JVI.00955-15. PMC   4542372 . PMID   26157120.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.