Antipsychotics, also known as neuroleptics, are a class of psychotropic medication primarily used to manage psychosis, principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay together with mood stabilizers in the treatment of bipolar disorder.
Psychosis is a condition of the mind that results in difficulties determining what is real and what is not real. Symptoms may include delusions and hallucinations, among other features. Additional symptoms are incoherent speech and behavior that is inappropriate for a given situation. There may also be sleep problems, social withdrawal, lack of motivation, and difficulties carrying out daily activities. Psychosis can have serious adverse outcomes.
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations, delusions and disorganized thinking. Other symptoms include social withdrawal and flat affect. Symptoms typically develop gradually, begin during young adulthood, and in many cases are resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a psychiatric history that includes the person's reported experiences, and reports of others familiar with the person. For a diagnosis of schizophrenia, the described symptoms need to have been present for at least six months or one month. Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders and obsessive–compulsive disorder.
Clozapine is a psychiatric medication and is the first atypical antipsychotic to be discovered. It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics or who have been unable to tolerate other drugs due to extrapyramidal side effects. It is also used for the treatment of psychosis in Parkinson's disease. Clozapine is regarded as the gold-standard treatment when most other medications are ineffective and its use is recommended by multiple international treatment guidelines, after resistance to two other antipsychotic medications.
A psychiatric or psychotropic medication is a psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system. Thus, these medications are used to treat mental illnesses. These medications are typically made of synthetic chemical compounds and are usually prescribed in psychiatric settings, potentially involuntarily during commitment. Since the mid-20th century, such medications have been leading treatments for a broad range of mental disorders and have decreased the need for long-term hospitalization, thereby lowering the cost of mental health care. The recidivism or rehospitalization of the mentally ill is at a high rate in many countries, and the reasons for the relapses are under research.
Olanzapine is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. For schizophrenia, it can be used for both new-onset disease and long-term maintenance. It is taken by mouth or by injection into a muscle.
Schizoaffective disorder is a mental disorder characterized by abnormal thought processes and an unstable mood. This diagnosis requires symptoms of both schizophrenia and a mood disorder: either bipolar disorder or depression. The main criterion is the presence of psychotic symptoms for at least two weeks without any mood symptoms. Schizoaffective disorder can often be misdiagnosed when the correct diagnosis may be psychotic depression, bipolar I disorder, schizophreniform disorder, or schizophrenia. This is a problem as treatment and prognosis differ greatly for most of these diagnoses.
Ganser syndrome is a rare dissociative disorder characterized by nonsensical or wrong answers to questions and other dissociative symptoms such as fugue, amnesia or conversion disorder, often with visual pseudohallucinations and a decreased state of consciousness. The syndrome has also been called nonsense syndrome, balderdash syndrome, syndrome of approximate answers, hysterical pseudodementia or prison psychosis.
Sir Robin MacGregor Murray FRS is a Scottish psychiatrist, Professor of Psychiatric Research at the Institute of Psychiatry, King's College London. He has treated patients with schizophrenia and bipolar illness referred to the National Psychosis Unit of the South London and Maudsley NHS Trust because they fail to respond to treatment, or cannot get appropriate treatment, locally; he sees patients privately if they are unable to obtain an NHS referral.
Postpartum psychosis(PPP), also known as puerperal psychosis or peripartum psychosis, involves the abrupt onset of psychotic symptoms shortly following childbirth, typically within two weeks of delivery but less than 4 weeks postpartum. PPP is a condition currently represented under "Brief Psychotic Disorder" in the Diagnostic and Statistical Manual of Mental Disorders, Volume V (DSM-V). Symptoms may include delusions, hallucinations, disorganized speech (e.g, incoherent speech), and/or abnormal motor behavior (e.g., catatonia). Other symptoms frequently associated with PPP include confusion, disorganized thought, severe difficulty sleeping, variations of mood disorders (including depression, agitation, mania, or a combination of the above), as well as cognitive features such as consciousness that comes and goes (waxing and waning) or disorientation.
Allen J. Frances is an American psychiatrist. He is currently Professor and Chairman Emeritus of the Department of Psychiatry and Behavioral Sciences at Duke University School of Medicine. He is best known for serving as chair of the American Psychiatric Association task force overseeing the development and revision of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Frances is the founding editor of two well-known psychiatric journals: the Journal of Personality Disorders and the Journal of Psychiatric Practice.
Sophia Frangou is a professor of psychiatry at the Icahn School of Medicine at Mount Sinai where she heads the Psychosis Research Program. She is a Fellow of the Royal College of Psychiatrists and vice-chair of the RCPsych Panamerican Division. She is a Fellow of the European Psychiatric Association (EPA) and of the American Psychiatric Association (APA). She served as vice-president for Research of the International Society for Bipolar Disorders from 2010 to 2014. She has also served on the Council of the British Association for Psychopharmacology. She is founding member of the EPA NeuroImaging section and founding chair of the Brain Imaging Network of the European College of Neuropsychopharmacology. She is one of the two Editors of European Psychiatry, the official Journal of the European Psychiatric Association.
Mario Di Fiorino is an Italian psychiatrist and Director of Psychiatry at the Ospedale Versilia in Lido di Camaiore (LU), Italy till 31 May 2023. The author of numerous scientific papers and books, his main areas of research are related to mental manipulation, violence, and dissociative disorders.
Mary Cannon is an Irish psychiatrist and research scientist. She has received the Royal Academy of Medicine in Ireland's "Doctors Award" for psychiatry, and is among the most highly cited scientists in the world. She is best known for her study of the risk factors for mental illness in young people.
Jayashri Kulkarni is a Professor of Psychiatry at the Alfred Health and Monash University who works in the area of women's mental health. She has written about Premenstrual syndrome. She has used hormones to treat schizophrenia, bipolar disorder and depression in women. She founded and heads the Monash Alfred Psychiatry Research Centre, a clinical psychiatry research centre which currently has more than 160 staff and students.
Mauricio Tohen is a Mexican American research psychiatrist, Distinguished Professor, and Chairman of the Department of Psychiatry & Behavioral Sciences at the University of New Mexico. Tohen's research has focused on the epidemiology, outcome, and treatment of bipolar and psychotic disorders, and is especially known for innovating the design of clinical trials and the criteria to determine outcome in such diseases. Tohen has edited several books on his specialties. His social awareness has been noted in the promotion of programs to improve mental health care in areas such as substance abuse, bipolar disorder and schizophrenia.
Marion Leboyer is a French psychiatrist, university professor and hospital practitioner at the Paris-Est Créteil University (UPEC).
Diana Prata is a Portuguese neuroscientist who concentrates on identifying the biological basis of human behaviour. She reported the first evidence that schizophrenia-risk genes can also predispose to bipolar disorder and has also investigated reasons why people respond differently to antipsychotic medications. She is head of the Biomedical Neuroscience Lab at the University of Lisbon.
Benedicto Crespo Facorro is a psychiatrist and professor of psychiatry with the School of Medicine at the Hospital Universitario Virgen del Rocío, Universidad de Sevilla, in Seville. Facorro is notable for his research work in the area of early psychosis and schizophrenia and for having led one of the first early psychosis early intervention programs in Spain (PAFIP) for over two decades. Facorro is one of the only four researchers from Spain listed in the authors' collaborative network of the authors that published the greatest number of research papers on antipsychotics and schizophrenia over the last 50 years.
Miquel Bernardo Arroyo was born in 1954, Barcelona, Spain. He is a psychiatrist and a Full Professor of Psychiatry at the University of Barcelona. Is known for his work in the field of schizophrenia and related disorders.
