The National Academies of Sciences, Engineering, and Medicine is a congressionally chartered organization that serves as the collective scientific national academy of the United States. The name is used interchangeably in two senses: (1) as an umbrella term or parent organization for its three sub-divisions that operate as quasi-independent honorific learned society member organizations known as the National Academy of Sciences (NAS), the National Academy of Engineering (NAE), and the National Academy of Medicine (NAM); and (2) as the brand for studies and reports issued by the unified operating arm of the three academies originally known as the National Research Council (NRC). The National Academies also serve as public policy advisors, research institutes, think tanks, and public administration consultants on issues of public importance or on request by the government.
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM).
David Baltimore is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is President Emeritus and Distinguished Professor of Biology at the California Institute of Technology (Caltech), where he served as president from 1997 to 2006. He also served as the director of the Joint Center for Translational Medicine, which joined Caltech and UCLA in a program to translate basic scientific discoveries into clinical realities. He also formerly served as president of Rockefeller University from 1990 to 1991, founder and director of the Whitehead Institute of Biomedical Research from 1982 to 1990, and was president of the American Association for the Advancement of Science in 2007.
The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Sciences (NAS), National Academy of Engineering (NAE), and the National Research Council (NRC).
The American Society for Microbiology (ASM), originally the Society of American Bacteriologists, is a professional organization for scientists who study viruses, bacteria, fungi, algae, and protozoa as well as other aspects of microbiology. It was founded in 1899. The Society publishes a variety of scientific journals, textbooks, and other educational materials related to microbiology and infectious diseases. ASM organizes annual meetings, as well as workshops and professional development opportunities for its members.
Howard Martin Temin was an American geneticist and virologist. He discovered reverse transcriptase in the 1970s at the University of Wisconsin–Madison, for which he shared the 1975 Nobel Prize in Physiology or Medicine with Renato Dulbecco and David Baltimore.
George McClelland Whitesides is an American chemist and professor of chemistry at Harvard University. He is best known for his work in the areas of nuclear magnetic resonance spectroscopy, organometallic chemistry, molecular self-assembly, soft lithography, microfabrication, microfluidics, and nanotechnology. A prolific author and patent holder who has received many awards, he received the highest Hirsch index rating of all living chemists in 2011.
Daniel Edward Koshland Jr. was an American biochemist. He reorganized the study of biology at the University of California, Berkeley, and was the editor of the leading U.S. science journal, Science, from 1985 to 1995. He was a member of the United States National Academy of Sciences, the American Academy of Arts and Sciences, and the American Philosophical Society.
The Carnegie Institution of Washington, known also for public purposes as the Carnegie Institution for Science (CIS), is an organization in the United States established to fund and perform scientific research. The institution is headquartered in Washington, D.C. As of June 30, 2020, the Institution's endowment was valued at $926.9 million. In 2018 the expenses for scientific programs and administration were $96.6 million. Eric Isaacs is president of the institution.
Marian Elliott "Bunny" Koshland was an American immunologist who discovered that the differences in amino acid composition of antibodies explain the efficiency and effectiveness with which they combat a huge range of foreign invaders.
Peter S. Kim is an American scientist. He was president of Merck Research Laboratories (MRL) 2003–2013 and is currently Virginia & D.K. Ludwig Professor of Biochemistry at Stanford University, Institute Scholar at Stanford ChEM-H, and Lead Investigator of the Infectious Disease Initiative at the Chan Zuckerberg Biohub.
Harvey Franklin Lodish is a molecular and cell biologist, professor at the Massachusetts Institute of Technology (MIT), Founding Member of the Whitehead Institute for Biomedical Research, and lead author of the textbook Molecular Cell Biology. Lodish's research focused on cell surface proteins and other important areas at the interface between molecular cell biology and medicine.
Richard H. Scheller is the former Chief Science Officer and Head of Therapeutics at 23andMe and the former Executive Vice President of Research and Early Development at Genentech. He was a professor at Stanford University from 1982 to 2001 before joining Genentech. He has been awarded the Alan T. Waterman Award in 1989, the W. Alden Spencer Award in 1993 and the NAS Award in Molecular Biology in 1997, won the 2010 Kavli Prize in Neuroscience with Thomas C. Südhof and James E. Rothman, and won the 2013 Albert Lasker Award for Basic Medical Research with Thomas Südhof. He was also given the Life Sciences Distinguished Alumni Award from University of Wisconsin–Madison. He is a Fellow of the American Academy of Arts and Sciences and a Member of the National Academy of Sciences.
Douglas E. Koshland is a professor of molecular and cellular biology at the University of California, Berkeley.
Gloria M. Coruzzi is an American molecular biologist specializing in plant systems biology and evolutionary genomics.
Elaine Ann Ostrander is an American geneticist at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in Bethesda, Maryland. She holds a number of professional academic appointments, currently serving as Distinguished and Senior Investigator and head of the NHGRI Section of Comparative Genomics; and Chief of the Cancer Genetics and Comparative Genomics Branch. She is known for her research on prostate cancer susceptibility in humans and for conducting genetic investigations with the Canis familiaris —the domestic dog— model, which she has used to study disease susceptibility and frequency and other aspects of natural variation across mammals. In 2007, her laboratory showed that much of the variation in body size of domestic dogs is due to sequence changes in a single gene encoding a growth-promoting protein.
Dipankar Chatterji is an Indian molecular biologist and the Honorary Professor at Molecular Biophysics Unit, Indian Institute of Science, a multidisciplinary research institute under the Department of Science and Technology of the Government of India. He is known for his pioneering research on bacterial transcription. He is a recipient of Shanti Swarup Bhatnagar Prize and is an elected fellow of all the major Indian science academies. The Government of India awarded him the fourth highest civilian honour of the Padma Shri, in 2016, for his contributions to science and engineering.
John Barnabas (1929–1994) was an Indian evolutionary biologist, known for his contributions in the fields of Molecular Systematics and Evolution. He was a member of the Science Advisory Committee to the cabinet as well as the Department of Biotechnology of the Government of India. A Jawaharlal Nehru Fellow, Barnabas was also an elected fellow of the Indian Academy of Sciences, Indian National Science Academy and the National Academy of Sciences, India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1974, for his contributions to biological sciences.
Alejandro Sánchez Alvarado is a molecular biologist, an investigator of the Howard Hughes Medical Institute, and executive director and Chief Scientific Officer of the Stowers Institute for Medical Research. The Sánchez Alvarado Laboratory focuses on understanding the regenerative capabilities of the planarian flatworm Schmidtea mediterranea. In 2015, Sánchez Alvarado was elected a fellow of the American Academy of Arts and Sciences, and to the National Academy of Sciences in 2018 for his distinguished and continuing achievements in original scientific research.
Gain-of-function research is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis, transmissibility, or host range, i.e., the types of hosts that a microorganism can infect. This research is intended to reveal targets to better predict emerging infectious diseases and to develop vaccines and therapeutics. For example, influenza B can infect only humans and harbor seals. Introducing a mutation that would allow influenza B to infect rabbits in a controlled laboratory situation would be considered a gain-of-function experiment, as the virus did not previously have that function. That type of experiment could then help reveal which parts of the virus's genome correspond to the species that it can infect, enabling the creation of antiviral medicines which block this function.
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