Markita del Carpio Landry

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Markita Landry
Markita Landry.jpg
Alma mater University of North Carolina at Chapel Hill
University of Illinois at Urbana-Champaign
Scientific career
Institutions Massachusetts Institute of Technology
Osaka University
Duke University
University of North Carolina at Chapel Hill
Thesis Single-molecule methods for an improved understanding of biophysical interactions: from fundamental biology to applied nanotechnology.  (2012)
Website Landry Lab

Markita del Carpio Landry is a Bolivian-American chemist who is an assistant professor in the department of chemical engineering at the University of California, Berkeley. Her research considers nanomaterials for brain imaging and the development of sustainable crops. She was a recipient of the 2022 Vilcek prize for creative promise. del Carpio Landry's work has been featured on NPR, [1] popular mechanics, [2] the San Francisco Chronicle, [3] and C&E News. [4]

Contents

Early life and education

del Carpio Landry's parents are both teachers, and she has said that her early training was in curiosity-based science. [5] Landry earned her bachelor's degrees at the University of North Carolina at Chapel Hill, where she majored in both chemistry and physics. [6] She moved to the University of Illinois Urbana-Champaign for doctoral studies and earned a Ph.D. in chemical physics. Her research considered the development of single-molecule spectroscopies for investigating DNA polymer oxidative damage. [7] del Carpio Landry was a National Science Foundation postdoctoral scholar at the Massachusetts Institute of Technology. She performed research at both the Technical University of Munich and Osaka University. [6] del Carpio Landry is a fluent speaker of French, English, and Spanish.

Research and career

In July 2016, del Carpio Landry was appointed to the faculty at Berkeley, where she started to explore nanotechnology-based approaches to image neuromodulation in the brain using synthetic nanoparticle-polymer conjugates. [8] Such materials are incredibly versatile, with tunable chemical and physical properties. They can be processed using low cost fabrication techniques, permitting the creation of biomimetic structures. She uses functionalism carbon nanotubes to detect the neurotransmitters dopamine and norepinephrine with high spatial and temporal resolution. [9] She simultaneously develops near-infrared fluorescent probes to explore fundamental biological processes. [10]

del Carpio Landry has also demonstrated that carbon nanotubes can be used to deliver DNA into plant cells [9] [11] with applications in plant genome editing. [12] Delivering DNA to plants is complicated due to the rigid, multi-layer cell walls, yet del Carpio Landry has also demonstrated that nanoparticles can be used to deliver RNA into plants. [13] [14] During the COVID-19 pandemic, del Carpio Landry started to explore nanosenors for detecting the spike proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [15] and to increase the sensitivity of RT-qPCR detection of SARS-CoV-2 infections. [16]

Awards and honors

Selected publications

Related Research Articles

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A carbon nanotube (CNT) is a tube made of carbon with a diameter in the nanometer range (nanoscale). They are one of the allotropes of carbon.

<span class="mw-page-title-main">Nanotechnology</span> Field of applied science involving control of matter on atomic and (supra)molecular scales

Nanotechnology, often shortened to nanotech, is the use of matter on atomic, molecular, and supramolecular scales for industrial purposes. The earliest, widespread description of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabrication of macroscale products, also now referred to as molecular nanotechnology. A more generalized description of nanotechnology was subsequently established by the National Nanotechnology Initiative, which defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (nm). This definition reflects the fact that quantum mechanical effects are important at this quantum-realm scale, and so the definition shifted from a particular technological goal to a research category inclusive of all types of research and technologies that deal with the special properties of matter which occur below the given size threshold. It is therefore common to see the plural form "nanotechnologies" as well as "nanoscale technologies" to refer to the broad range of research and applications whose common trait is size.

<span class="mw-page-title-main">Molecular engineering</span> Field of study in molecular properties

Molecular engineering is an emerging field of study concerned with the design and testing of molecular properties, behavior and interactions in order to assemble better materials, systems, and processes for specific functions. This approach, in which observable properties of a macroscopic system are influenced by direct alteration of a molecular structure, falls into the broader category of “bottom-up” design.

<span class="mw-page-title-main">Molecular recognition</span> Type of non-covalent bonding

The term molecular recognition refers to the specific interaction between two or more molecules through noncovalent bonding such as hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interactions, halogen bonding, or resonant interaction effects. In addition to these direct interactions, solvents can play a dominant indirect role in driving molecular recognition in solution. The host and guest involved in molecular recognition exhibit molecular complementarity. Exceptions are molecular containers, including e.g. nanotubes, in which portals essentially control selectivity.

<span class="mw-page-title-main">Nanobiotechnology</span> Intersection of nanotechnology and biology

Nanobiotechnology, bionanotechnology, and nanobiology are terms that refer to the intersection of nanotechnology and biology. Given that the subject is one that has only emerged very recently, bionanotechnology and nanobiotechnology serve as blanket terms for various related technologies.

Phaedon Avouris is a Greek chemical physicist and materials scientist. He is an IBM Fellow and was formerly the group leader for Nanometer Scale Science and Technology at the Thomas J. Watson Research Center in Yorktown Heights, New York.

<span class="mw-page-title-main">Nanochemistry</span> Combination of chemistry and nanoscience

Nanochemistry is an emerging sub-discipline of the chemical and material sciences that deals with the development of new methods for creating nanoscale materials. The term "nanochemistry" was first used by Ozin in 1992 as 'the uses of chemical synthesis to reproducibly afford nanomaterials from the atom "up", contrary to the nanoengineering and nanophysics approach that operates from the bulk "down"'. Nanochemistry focuses on solid-state chemistry that emphasizes synthesis of building blocks that are dependent on size, surface, shape, and defect properties, rather than the actual production of matter. Atomic and molecular properties mainly deal with the degrees of freedom of atoms in the periodic table. However, nanochemistry introduced other degrees of freedom that controls material's behaviors by transformation into solutions. Nanoscale objects exhibit novel material properties, largely as a consequence of their finite small size. Several chemical modifications on nanometer-scaled structures approve size dependent effects.

The history of nanotechnology traces the development of the concepts and experimental work falling under the broad category of nanotechnology. Although nanotechnology is a relatively recent development in scientific research, the development of its central concepts happened over a longer period of time. The emergence of nanotechnology in the 1980s was caused by the convergence of experimental advances such as the invention of the scanning tunneling microscope in 1981 and the discovery of fullerenes in 1985, with the elucidation and popularization of a conceptual framework for the goals of nanotechnology beginning with the 1986 publication of the book Engines of Creation. The field was subject to growing public awareness and controversy in the early 2000s, with prominent debates about both its potential implications as well as the feasibility of the applications envisioned by advocates of molecular nanotechnology, and with governments moving to promote and fund research into nanotechnology. The early 2000s also saw the beginnings of commercial applications of nanotechnology, although these were limited to bulk applications of nanomaterials rather than the transformative applications envisioned by the field.

Nanotoxicology is the study of the toxicity of nanomaterials. Because of quantum size effects and large surface area to volume ratio, nanomaterials have unique properties compared with their larger counterparts that affect their toxicity. Of the possible hazards, inhalation exposure appears to present the most concern, with animal studies showing pulmonary effects such as inflammation, fibrosis, and carcinogenicity for some nanomaterials. Skin contact and ingestion exposure are also a concern.

The following outline is provided as an overview of and topical guide to nanotechnology:

<span class="mw-page-title-main">Thalappil Pradeep</span> Indian scientist

Thalappil Pradeep is an institute professor and professor of chemistry in the Department of Chemistry at the Indian Institute of Technology Madras. He is also the Deepak Parekh Chair Professor. In 2020 he received the Padma Shri award for his distinguished work in the field of Science and Technology. He has received the Nikkei Asia Prize (2020), The World Academy of Sciences (TWAS) prize (2018), and the Shanti Swarup Bhatnagar Prize for Science and Technology in 2008 by Council of Scientific and Industrial Research.

Green nanotechnology refers to the use of nanotechnology to enhance the environmental sustainability of processes producing negative externalities. It also refers to the use of the products of nanotechnology to enhance sustainability. It includes making green nano-products and using nano-products in support of sustainability.

<span class="mw-page-title-main">DNA nanotechnology</span> The design and manufacture of artificial nucleic acid structures for technological uses

DNA nanotechnology is the design and manufacture of artificial nucleic acid structures for technological uses. In this field, nucleic acids are used as non-biological engineering materials for nanotechnology rather than as the carriers of genetic information in living cells. Researchers in the field have created static structures such as two- and three-dimensional crystal lattices, nanotubes, polyhedra, and arbitrary shapes, and functional devices such as molecular machines and DNA computers. The field is beginning to be used as a tool to solve basic science problems in structural biology and biophysics, including applications in X-ray crystallography and nuclear magnetic resonance spectroscopy of proteins to determine structures. Potential applications in molecular scale electronics and nanomedicine are also being investigated.

<span class="mw-page-title-main">Nanoparticle–biomolecule conjugate</span> Tailored macromolecule with covalently-bonded bio-active substances targeting specific tissues

A nanoparticle–biomolecule conjugate is a nanoparticle with biomolecules attached to its surface. Nanoparticles are minuscule particles, typically measured in nanometers (nm), that are used in nanobiotechnology to explore the functions of biomolecules. Properties of the ultrafine particles are characterized by the components on their surfaces more so than larger structures, such as cells, due to large surface area-to-volume ratios. Large surface area-to-volume-ratios of nanoparticles optimize the potential for interactions with biomolecules.

The applications of nanotechnology, commonly incorporate industrial, medicinal, and energy uses. These include more durable construction materials, therapeutic drug delivery, and higher density hydrogen fuel cells that are environmentally friendly. Being that nanoparticles and nanodevices are highly versatile through modification of their physiochemical properties, they have found uses in nanoscale electronics, cancer treatments, vaccines, hydrogen fuel cells, and nanographene batteries.

Michael Steven Strano is an American chemical engineer and the Carbon P. Dubbs Professor of Chemical Engineering at Massachusetts Institute of Technology (MIT). He is particularly interested in quantum-confined materials. Strano was appointed editor-in-chief of Carbon in 2016. In 2017, Strano was elected a member of the National Academy of Engineering "for contributions to nanotechnology, including fluorescent sensors for human health and solar and thermal energy devices."

<span class="mw-page-title-main">Synthesis of carbon nanotubes</span> Class of manufacturing

Techniques have been developed to produce carbon nanotubes in sizable quantities, including arc discharge, laser ablation, high-pressure carbon monoxide disproportionation, and chemical vapor deposition (CVD). Most of these processes take place in a vacuum or with process gases. CVD growth of CNTs can occur in vacuum or at atmospheric pressure. Large quantities of nanotubes can be synthesized by these methods; advances in catalysis and continuous growth are making CNTs more commercially viable.

Niveen M. Khashab is a Lebanese chemist and an associate Professor of chemical Sciences and engineering at King Abdullah University of Science and Technology in Saudi Arabia since 2009. She is a laureate of the 2017 L'Oréal-UNESCO Awards for Women in Science "for her contributions to innovative smart hybrid materials aimed at drug delivery and for developing new techniques to monitor intracellular antioxidant activity." She is also a fellow of the Royal Chemical Society, and a member of the American Chemical Society.

<span class="mw-page-title-main">Characterization of nanoparticles</span> Measurement of physical and chemical properties of nanoparticles

The characterization of nanoparticles is a branch of nanometrology that deals with the characterization, or measurement, of the physical and chemical properties of nanoparticles. Nanoparticles measure less than 100 nanometers in at least one of their external dimensions, and are often engineered for their unique properties. Nanoparticles are unlike conventional chemicals in that their chemical composition and concentration are not sufficient metrics for a complete description, because they vary in other physical properties such as size, shape, surface properties, crystallinity, and dispersion state.

Research has shown nanoparticles to be a groundbreaking tool for tackling many arising global issues, the agricultural industry being no exception. In general, a nanoparticle is defined as any particle where one characteristic dimension is 100nm or less. Because of their unique size, these particles begin to exhibit properties that their larger counterparts may not. Due to their scale, quantum mechanical interactions become more important than classic mechanical forces, allowing for the prevalence of unique physical and chemical properties due to their extremely high surface-to-body ratio. Properties such as cation exchange capacity, enhanced diffusion, ion adsorption, and complexation are enhanced when operating at nanoscale.

References

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