Marta Catellani

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Marta Catellani is an Italian chemist known for her discovery of the eponymous Catellani reaction in 1997. She was elected to the European Academy of Sciences in 2016. Catellani earned her Ph.D. in chemistry in 1971 from the University of Parma, where, as of 2019, she is a professor and chairs the Department of Organic Chemistry. [1] [2] [3]

Catellani completed her postdoctoral education at the University of Chicago. She has served as a visiting professor at Moscow State University (1992), Beijing Institute of Technology (2004), and University of Xi'an (2004). She was awarded a fellowship at the Japan Society for the Promotion of Science in 2012. [2] [3]

Her research focuses on palladium as a catalyst for multistep organic reactions. [2] [3]

The Catellani Reaction

Catellani and her team in 1997 found a method, known as the Catellani Reaction, for creation of carbon-carbon bonds. [4] [5] [6] [7] which are useful in construction of more complex compounds. [5]

The Catellani Reaction has opened the door to other discoveries or improvements in chemistry. Specifically in the world of pharmaceuticals, the it has been useful for synthesizing drugs more efficiently to aid in their development. Lenoxipen is an example of one of the complex compounds now much easier to achieve with the discovery of Catellani Reactions. [8] This compound belongs to a group of compounds known as Lignans that are useful for relieving pain and may provide benefits to cancer patients. [8] These examples of the uses for Catellani Reactions show the vast and indirect benefits to its discovery. To chemists, the Catellani Reaction is a tool that acts to optimize the process for making new compounds. These new compounds are pivotal for advancing what is possible through chemistry. As new scientists study and try to build upon the Catellani Reaction, it is important to remember who provided the first understanding as it would open up a new world of opportunity.

References

  1. ↑ "European Academy of Sciences - Marta Catellani". www.eurasc.org. Retrieved 2019-10-18.
  2. 1 2 3 "Prof. Dr. Marta Catellani « ISHC 2018". Archived from the original on 2019-10-18. Retrieved 2019-10-18.
  3. 1 2 3 Olson, Julie A.; Shea, Kevin M. (2011-05-17). "Critical Perspective: Named Reactions Discovered and Developed by Women" . Accounts of Chemical Research. 44 (5): 311–321. doi:10.1021/ar100114m. ISSN   0001-4842. PMID   21417324.
  4. ↑ Liu, Ze-Shui; Gao, Qianwen; Cheng, Hong-Gang; Zhou, Qianghui (2018-10-17). "Alkylating Reagents Employed in Catellani-Type Reactions". Chemistry: A European Journal. 24 (58): 15461–15476. doi:10.1002/chem.201802818. PMID   30016558. S2CID   51680147.
  5. 1 2 Yamamoto, Y.; Murayama, T.; Jiang, J.; Yasui, T.; Shibuya, M. (2018-01-31). "The vinylogous Catellani reaction: a combined computational and experimental study". Chemical Science. 9 (5): 1191–1199. doi:10.1039/C7SC04265E. ISSN   2041-6539. PMC   5885779 . PMID   29675164.
  6. ↑ Martins, Andrew; Mariampillai, Brian; Lautens, Mark (2010). Synthesis in the Key of Catellani: Norbornene-Mediated ortho C-H Functionalization. Topics in Current Chemistry. Vol. 292. pp. 1–33. Bibcode:2010cha..book....1M. doi:10.1007/128_2009_13. ISBN   978-3-642-12355-9. PMID   21500401.
  7. ↑ Wheeler, Philip (2019-03-18). "Creating carbon–carbon bonds via transition metal catalysis". Chemistry World. Retrieved 2020-04-26.
  8. 1 2 Weinstabl, Harald; Suhartono, Marcel; Qureshi, Zafar; Lautens, Mark (2013-05-10). "Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction". Angewandte Chemie International Edition in English. 52 (20): 5305–5308. doi:10.1002/anie.201302327. ISSN   1433-7851. PMC   3715096 . PMID   23592590.
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