Cast and characters
J. D. Pardo (Ezekiel "EZ" Reyes), Sarah Bolger (Emily Thomas), and Michael Irby (Obispo "Bishop" Losa)
Carla Baratta (Adelita), Richard Cabral (Johnny "El Coco" Cruz), and Raoul Trujillo (Che "Taza" Romero)
Main
- J. D. Pardo as Ezekiel "EZ" Reyes, a full patch for the Mayans and brother to Angel Reyes.
- Clayton Cardenas as Angel Reyes, EZ's brother and Él Secretario of Mayans M.C., Santo Padre Charter
- Sarah Bolger as Emily Thomas, childhood sweetheart of EZ, who is now married to Miguel Galindo, and the mother of their infant son.
- Michael Irby as Obispo "Bishop" Losa, president of Mayans M.C.'s Santo Padre Charter.
- Carla Baratta as Adelita, who as a child, watched her family die at the hands of the Galindo cartel.
- Richard Cabral as Johnny "El Coco" Cruz, a full patch member of Mayans M.C.
- Raoul Trujillo as Che "Taza" Romero, Vice Presidente of Mayans M.C., Santo Padre Charter.
- Danny Pino as Miguel Galindo, the son of Galindo Cartel founder Jose Galindo.
- Edward James Olmos as Felipe Reyes, the once-strong Mexican patriarch and Angel and EZ's father.
- Emilio Rivera as Marcus Álvarez, Consejero to Miguel Galindo, former president of the Mayans M.C. Oakland Charter and national president of the Mayans M.C., cousin of Obispo "Bishop" Losa
- Sulem Calderon as Gabriela "Gaby" Castillo, newly immigrated to the U.S. from Oaxaca, Mexico, she seeks to build a brighter future for herself and her family. After moving to Santo Padre, she starts a relationship with EZ until she leaves for Lodi to attend nursing school.
Special guests
- Ray McKinnon as Lincoln "Linc" James Potter, reprising his role from Sons of Anarchy as the Assistant U.S. Attorney, now investigating both the Mayans M.C. and Los Olvidados.
- David Labrava as Happy Lowman, SAMCRO Sergeant-at-Arms, who is responsible for the death of EZ and Angel's mother. [5]
Recurring
- Frankie Loyal as Hank "El Tranq" Loza, a former bare-knuckle brawler and El Pacificador (Sgt-at-Arms) of the Mayans M.C., Santo Padre Charter.
- Joseph Lucero as Neron "Creeper" Vargas, an ex-junkie from Los Angeles and Capitan Del Camino (Road Captain) of the Mayans M.C., Santo Padre Charter.
- Vincent Vargas as Gilberto "Gilly" Lopez, a former U.S. Army Ranger and a good-natured mixed martial arts (MMA) fighter and a full patch member of the Mayans M.C., Santo Padre Charter.
- Gino Vento as Nestor Oceteva, the head of security for the Galindo Cartel and a childhood friend of Miguel's who later becomes a prospect for the Mayans M.C., Santo Padre Charter.
- Joe Ordaz as Paco, Miguel's personal driver and a member of the Galindo Cartel.
- Salvador Chacón as Pablo, the second-in-command of Los Olvidados who serves as Adelita's right-hand man.
- Melony Ochoa as Mini, also known as "La Ratona" (The Mouse), a child member of Los Olvidados who has a close relationship with Adelita.
- Alexandra Barreto as Antonia Pena, the mayor of Santo Padre and Katrina's wife. She is the former lover of Bishop and the mother of their deceased son, Aidan Losa.
- Emily Tosta as Leticia Cruz, Coco's daughter who was raised by her grandmother Celia for most of her life believing she was his younger sister.
- Ivo Nandi as Oscar "El Oso" Ramos, reprising his role from Sons of Anarchy as the Presidente of the Mayans M.C., Stockton Charter and one of the three Kings of the Mayans M.C.
- Jimmy Gonzales as Canche, the Presidente of the Mayans M.C., Yuma Charter and one of the three Kings of the Mayans M.C.
- Mía Maestro as Sederica Palomo, the governor of Baja California who works with Miguel Galindo in secret.
- Efrat Dor as Anna Linares, a government agent working with Lincoln Potter in the investigation of the Mayans M.C. and Los Olvidados.
- Mike Beltran as Ibarra, the Presidente of the Mayans M.C., Tucson Charter and a close ally of the Santo Padre charter.
- Vanessa Giselle as Hope, a heroin addict who forms a close relationship with Coco. She is also a member of Isaac's drug community at Meth Mountain.
- Gregory Cruz as El Palo, El Unico (The One, aka President) of the Vatos Malditos Motorcycle Club, who make their money through human trafficking and recruit members without the prospecting process. He later patches over to the Mayans M.C., Yuma Charter. He is also the brother of Laura.
- Momo Rodriguez as Esteban "Steve" Estrada, a former prospect sponsored by Hank and now full patch member of the Mayans M.C., Santo Padre Charter, who's dreamed of joining a M.C. his whole life.
- Justina Adorno as Stephanie, also known as "Nails", one of the bartenders at the clubhouse of the Mayans M.C., Santo Padre Charter. She later becomes engaged to Angel after a recurring fling with him.
- Grace Rizzo as Jess, one of the bartenders at the clubhouse of the Mayans M.C., Santo Padre Charter whose sister, Jazmine, is close to a member of SAMDINO.
- Patricia de Leon as Diana Alvarez, the wife of Marcus Alvarez who lives in Santo Padre with him and their children. [lower-alpha 1]
- Holland Roden as Erin Thomas, Emily Galindo's younger sister, who moves to Santo Padre to live with her and reconnect.
- JR Bourne as Isaac, the leader of a drug community based outside of Santo Padre at an encampment dubbed "Meth Mountain".
- Spenser Granese as Butterfly, a drug dealer and member of Isaac's drug community at Meth Mountain.
- Natalia Cordova-Buckley as Laura, El Palo's sister, who is distant from him for killing their brother.
Guests
- Edwin Hodge as Franky Rogan, a police officer in the Santo Padre Police Department.
- Greg Vrotsos as Terry, the Vice President of SAMDINO who seeks to start a war with the Mayans.
- Guillermo García as Ignacio, more commonly known as "El Banquero" (The Banker), the leader of Lobos Nueva Generación (LNG), a radical organization made up of the remnants of the Lobos Sonora Cartel, who were previously defeated by the Galindo Cartel under Jose Galindo.
