Mediso

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Mediso is a Hungarian manufacturer of nuclear medicine imaging equipment. Their range includes gamma cameras, PET scanners and software components, for clinical and preclinical imaging. The company was founded in 1990 and is headquartered in Budapest. [1] Mediso is one of Hungary's largest outward foreign direct investors. [2] [3]

Contents

As well as manufacturing equipment, the company also operates two diagnostic nuclear medicine centres, in Debrecen and Budapest, representing two-thirds of Hungary's PET-CT capacity. [4]

History

The company began as a provider of servicing for the products of the state-owned Gamma Művek (Gamma Works) instrument maker, and started producing its own equipment in 1994. [5] In 1998 it acquired the nuclear medicine assets of Gamma Works. [6] [7]

Products

Mediso is unique amongst clinical diagnostic imaging manufacturers in offering a modular three-modality combined SPECT-PET-CT imaging system. [8] This system was selected by the UK's metrology institute, the NPL, as the basis for its work in quantification of nuclear medicine. [9]

The company is active in preclinical imaging, marketing a range of hybrid imaging systems in many combinations including PET-MR and SPECT-MR. [10] [11] Preclinical products were initially developed in collaboration with Bioscan, an American company, with Mediso as OEM, however following a dispute over payment and contract terms Bioscan was dissolved in 2013 and ongoing support for the products developed under the partnership fell to Mediso. [12] [13] [14]

Related Research Articles

<span class="mw-page-title-main">Positron emission tomography</span> Medical imaging technique

Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, 18
F
-FDG is commonly used to detect cancer, NaF18
F
 is widely used for detecting bone formation, and oxygen-15 is sometimes used to measure blood flow.

<span class="mw-page-title-main">Radiology</span> Branch of Medicine

Radiology is the medical discipline that uses medical imaging to diagnose diseases and guide their treatment, within the bodies of humans and other animals. It began with radiography, but today it includes all imaging modalities, including those that use no electromagnetic radiation, as well as others that do, such as computed tomography (CT), fluoroscopy, and nuclear medicine including positron emission tomography (PET). Interventional radiology is the performance of usually minimally invasive medical procedures with the guidance of imaging technologies such as those mentioned above.

<span class="mw-page-title-main">Medical imaging</span> Technique and process of creating visual representations of the interior of a body

Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging.

<span class="mw-page-title-main">Single-photon emission computed tomography</span> Nuclear medicine tomographic imaging technique

Single-photon emission computed tomography is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera, but is able to provide true 3D information. This information is typically presented as cross-sectional slices through the patient, but can be freely reformatted or manipulated as required.

<span class="mw-page-title-main">Nuclear medicine</span> Medical specialty

Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is "radiology done inside out" because it records radiation emitting from within the body rather than radiation that is generated by external sources like X-rays. In addition, nuclear medicine scans differ from radiology, as the emphasis is not on imaging anatomy, but on the function. For such reason, it is called a physiological imaging modality. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) scans are the two most common imaging modalities in nuclear medicine.

<span class="mw-page-title-main">Scintigraphy</span> Diagnostic imaging test in nuclear medicine

Scintigraphy, also known as a gamma scan, is a diagnostic test in nuclear medicine, where radioisotopes attached to drugs that travel to a specific organ or tissue (radiopharmaceuticals) are taken internally and the emitted gamma radiation is captured by external detectors to form two-dimensional images in a similar process to the capture of x-ray images. In contrast, SPECT and positron emission tomography (PET) form 3-dimensional images and are therefore classified as separate techniques from scintigraphy, although they also use gamma cameras to detect internal radiation. Scintigraphy is unlike a diagnostic X-ray where external radiation is passed through the body to form an image.

Biodistribution is a method of tracking where compounds of interest travel in an experimental animal or human subject. For example, in the development of new compounds for PET scanning, a radioactive isotope is chemically joined with a peptide. This particular class of isotopes emits positrons. When ejected from the nucleus, positrons encounter an electron, and undergo annihilation which produces two gamma rays travelling in opposite directions. These gamma rays can be measured, and when compared to a standard, quantified.

<span class="mw-page-title-main">Bone scintigraphy</span>

A bone scan or bone scintigraphy is a nuclear medicine imaging technique of the bone. It can help diagnose a number of bone conditions, including cancer of the bone or metastasis, location of bone inflammation and fractures, and bone infection (osteomyelitis).

<span class="mw-page-title-main">Neuroimaging</span> Set of techniques to measure and visualize aspects of the nervous system

Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Increasingly it is also being used for quantitative studies of brain disease and psychiatric illness. Neuroimaging is a highly multidisciplinary research field and is not a medical specialty.

A gallium scan is a type of nuclear medicine test that uses either a gallium-67 (67Ga) or gallium-68 (68Ga) radiopharmaceutical to obtain images of a specific type of tissue, or disease state of tissue. Gallium salts like gallium citrate and gallium nitrate may be used. The form of salt is not important, since it is the freely dissolved gallium ion Ga3+ which is active. Both 67Ga and 68Ga salts have similar uptake mechanisms. Gallium can also be used in other forms, for example 68Ga-PSMA is used for cancer imaging. The gamma emission of gallium-67 is imaged by a gamma camera, while the positron emission of gallium-68 is imaged by positron emission tomography (PET).

Siemens Healthineers is a German medical device company. It is the parent company for several medical technology companies and is headquartered in Erlangen, Germany. The company dates its early beginnings in 1847 to a small family business in Berlin, co-founded by Werner von Siemens. Siemens Healthineers is 75% owned by Siemens. The name Siemens Medical Solutions was adopted in 2001, and the change to Siemens Healthcare was made in 2008. In 2015, Siemens named Bernd Montag as its new global CEO. In May 2016, the business operations of Siemens Healthcare were rebranded "Siemens Healthineers."

Functional imaging is a medical imaging technique of detecting or measuring changes in metabolism, blood flow, regional chemical composition, and absorption.

<span class="mw-page-title-main">PET-CT</span>

Positron emission tomography–computed tomography is a nuclear medicine technique which combines, in a single gantry, a positron emission tomography (PET) scanner and an x-ray computed tomography (CT) scanner, to acquire sequential images from both devices in the same session, which are combined into a single superposed (co-registered) image. Thus, functional imaging obtained by PET, which depicts the spatial distribution of metabolic or biochemical activity in the body can be more precisely aligned or correlated with anatomic imaging obtained by CT scanning. Two- and three-dimensional image reconstruction may be rendered as a function of a common software and control system.

Perfusion is the passage of fluid through the lymphatic system or blood vessels to an organ or a tissue. The practice of perfusion scanning is the process by which this perfusion can be observed, recorded and quantified. The term perfusion scanning encompasses a wide range of medical imaging modalities.

Nuclear medicine physicians, also called nuclear radiologists or simply nucleologists, are medical specialists that use tracers, usually radiopharmaceuticals, for diagnosis and therapy. Nuclear medicine procedures are the major clinical applications of molecular imaging and molecular therapy. In the United States, nuclear medicine physicians are certified by the American Board of Nuclear Medicine and the American Osteopathic Board of Nuclear Medicine.

Rubidium-82 (82Rb) is a radioactive isotope of rubidium. 82Rb is widely used in myocardial perfusion imaging. This isotope undergoes rapid uptake by myocardiocytes, which makes it a valuable tool for identifying myocardial ischemia in Positron Emission Tomography (PET) imaging. 82Rb is used in the pharmaceutical industry and is marketed as Rubidium-82 chloride under the trade names RUBY-FILL and CardioGen-82.

Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes. Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. Broadly speaking, these imaging systems can be categorized into primarily morphological/anatomical and primarily molecular imaging techniques. Techniques such as high-frequency micro-ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging, positron emission tomography (PET), and single photon emission computed tomography (SPECT) are usually used for molecular visualizations.

<span class="mw-page-title-main">PET-MRI</span>

Positron emission tomography–magnetic resonance imaging (PET–MRI) is a hybrid imaging technology that incorporates magnetic resonance imaging (MRI) soft tissue morphological imaging and positron emission tomography (PET) functional imaging.

<span class="mw-page-title-main">Cardiac imaging</span>

Cardiac imaging refers to non-invasive imaging of the heart using ultrasound, magnetic resonance imaging (MRI), computed tomography (CT), or nuclear medicine (NM) imaging with PET or SPECT. These cardiac techniques are otherwise referred to as echocardiography, Cardiac MRI, Cardiac CT, Cardiac PET and Cardiac SPECT including myocardial perfusion imaging.

Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals. Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution and, at the same time, allows to perform fast dynamic imaging of animals.

References

  1. ↑ "Chronology". Mediso Medical Imaging Systems. Retrieved 2 February 2020.
  2. ↑ Trąpczyński, Piotr; Puślecki, Łukasz; Jarosiński, Mirosław (2016). Competitiveness of CEE economies and businesses. Switzerland: Springer. p. 158. ISBN   9783319396545.
  3. ↑ Sass, Magdolna; Vlčková, Jana (December 2019). "Just Look behind the Data! Czech and Hungarian Outward Foreign Direct Investment and Multinationals" (PDF). Acta Oeconomica. 69 (S2): 73–105. doi: 10.1556/032.2019.69.S2.4 .
  4. ↑ Mihály, Sipos (16 March 2010). "Látogatóban a Mediso Kft.-nél". Elektronet (in Hungarian).
  5. ↑ Szegedi, Imre; Csanádi, Márton (30 May 2011). "A gamma-sugarak bűvöletében él Bagaméry István". Innotéka (in Hungarian).
  6. ↑ "Inside look - Mediso". Evolution Online. SKF. 27 September 2013. Retrieved 27 July 2020.
  7. ↑ "István Bagaméry". Gábor Dénes Klub (in Hungarian). Retrieved 27 July 2020.
  8. ↑ Wang, Ge; Zhang, Jie; Gao, Hao; Weir, Victor; Yu, Hengyong; Cong, Wenxiang; Xu, Xiaochen; Shen, Haiou; Bennett, James; Furth, Mark; Wang, Yue; Vannier, Michael; Chen, Xiaoyuan (29 June 2012). "Towards Omni-Tomography—Grand Fusion of Multiple Modalities for Simultaneous Interior Tomography". PLOS ONE. 7 (6): e39700. doi: 10.1371/journal.pone.0039700 . PMC   3387257 . PMID   22768108.
  9. ↑ "Nuclear medicine". NPL . Retrieved 2 February 2020.
  10. ↑ Shah, N. Jon (2018). Hybrid MR-PET Imaging: Systems, Methods and Applications. Royal Society of Chemistry. p. 221. ISBN   978-1-78801-074-0.
  11. ↑ Schober, Otmar; Kiessling, Fabian; Debus, Jürgen (2020). Molecular Imaging in Oncology. Springer Nature. p. 127. ISBN   978-3-030-42618-7.
  12. ↑ "MEDISO v. BIOSCAN, Decision of the United States District Court of Columbia, 11 Dec 2014". Jus Mundi. Retrieved 27 July 2020.
  13. ↑ "Mediso Maintains World-Wide Support for NanoSPECT/CT® and NanoPET/CT® Users". Mediso Medical Imaging Systems. 27 October 2013. Retrieved 27 July 2020.
  14. ↑ "BIOSCAN, Inc". OpenCorporates . Retrieved 27 July 2020.
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