Metallopharmaceutical

Carboplatin, an example of a metallopharmaceutical

A metallopharmaceutical is a drug that contains a metal as an active ingredient. ^{[1] [2]} Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals is crucially dependent on the respective trace metal binding forms. ^[3]

Examples of metallopharmaceuticals include:

• bismuth subsalicylate – a mild anti-diarrheal also used in treating peptic ulcers caused by antibiotic-resistant H. pylori ^{[4] [5]}
• cisplatin and carboplatin – platinum containing anticancer agents ^{[6] [7]}
• gold salts such as auranofin – anti-inflammatory for treatment of arthritis ^{[8] [9]}
• silver sulfadiazine – antibacterial ^{[10] [11]}
• zinc pyrithione – antibacterial and antifungal ^[12]

References

1. Guo J, Sadler PJ (1999). "Medicinal Inorganic Chemistry". Advances in Inorganic Chemistry. 49: 183–306. doi:10.1016/S0898-8838(08)60271-8. ISBN   9780120236497.
2. Ray S, Mohan R, Singh JK, Samantaray MK, Shaikh MM, Panda D, Ghosh P (December 2007). "Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes". J. Am. Chem. Soc. 129 (48): 15042–53. Bibcode:2007JAChS.12915042R. doi:10.1021/ja075889z. PMID   17988129.
3. Günther K, Weber G (1999). "Elementspeziesanalytik: Ein Überblick". Analytiker-Taschenbuch. Vol. 20. pp. 71–103. doi:10.1007/978-3-642-59914-9_3. ISBN   978-3-642-64181-7.
4. Fischbach L, Evans EL (August 2007). "Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori". Aliment. Pharmacol. Ther. 26 (3): 343–57. doi:10.1111/j.1365-2036.2007.03386.x. PMID   17635369. S2CID   20973127.
5. Graham DY, Shiotani A (June 2008). "New concepts of resistance in the treatment of Helicobacter pylori infections". Nat. Clin. Pract. Gastroenterol. Hepatol. 5 (6): 321–31. doi:10.1038/ncpgasthep1138. PMC   2841357 . PMID   18446147.
6. Lokich J, Anderson N (January 1998). "Carboplatin versus cisplatin in solid tumors: an analysis of the literature". Ann. Oncol. 9 (1): 13–21. doi: 10.1023/A:1008215213739 . PMID   9541678.
7. Go RS, Adjei AA (January 1999). "Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin". J. Clin. Oncol. 17 (1): 409–22. doi:10.1200/JCO.1999.17.1.409. PMID   10458260.
8. Messori L, Marcon G (2004). "Gold complexes in the treatment of rheumatoid arthritis". Met. Ions Biol. Syst. 41: 279–304. PMID   15206120.
9. Gaujoux-Viala C, Smolen JS, Landewé R, Dougados M, Kvien TK, Mola EM, Scholte-Voshaar M, van Riel P, Gossec L (June 2010). "Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis". Ann. Rheum. Dis. 69 (6): 1004–9. doi:10.1136/ard.2009.127225. PMID   20447954. S2CID   30886393.
10. Fuller FW (2009). "The side effects of silver sulfadiazine". J. Burn Care Res. 30 (3): 464–70. doi:10.1097/BCR.0b013e3181a28c9b. PMID   19349889. S2CID   3676574.
11. Carter MJ, Tingley-Kelley K, Warriner RA (October 2010). "Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta-analysis". J. Am. Acad. Dermatol. 63 (4): 668–79. doi:10.1016/j.jaad.2009.09.007. PMID   20471135.
12. Guthery E, Seal LA, Anderson EL (February 2005). "Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects". Am J Infect Control. 33 (1): 15–22. doi:10.1016/j.ajic.2004.07.012. PMC   7119132 . PMID   15685130.

Further reading

• Bonett A, Leone R, Muggia R, Howell SB, eds. (2008). Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. Humana Press. ISBN   978-1-60327-458-6.
• Clarke MJ, Sadler PJ (1999). Metallopharmaceuticals: Diagnosis and therapy. Springer. ISBN   978-3-540-65308-0.
• Clarke MJ, Sadler PJ (1999). Metallopharmaceuticals I: DNA Interactions. Springer. ISBN   978-3-540-64889-5.
• Gielen M, Tiekink ER, eds. (2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN   978-0-470-86403-6.
• Jones CJ, Thornback J (2007). Medicinal Applications of Coordination Chemistry. RSC Publishing. ISBN   978-0-85404-596-9.