Michelle Linterman

Last updated

Michelle Linterman
Born
Michelle Linterman

Christchurch, New Zealand
Alma mater Victoria University of Wellington
Australian National University
Scientific career
Institutions Babraham Institute
Thesis Roquin controls germinal center formation and tolerance  (2009)

Michelle Linterman (born 1983) is a New Zealand immunologist. She is a group leader at the Babraham Institute in the United Kingdom, where she researches the biology of the germinal center response after immunisation and infection.

Contents

Early life and education

Linterman was born in Christchurch, New Zealand, the daughter of Louisa and Robert Linterman, and grew up in Waikanae. [1] She undertook undergraduate studies in biomedical sciences at Victoria University of Wellington (VUW) at the same time that a scientific revolution was occurring in genetics, [1] and graduated with a Bachelor of Biomedical Sciences degree in 2005. [2]

Linterman went to Canberra and completed a summer studentship with Carola Vinuesa at the Australian National University (ANU). Linterman ended up staying at ANU for a year to work on human genetics, before deciding to complete a doctorate. She started working with genetically modified mice to better understand disease. Vinuesa had just discovered RC3H1 using these mice, and Linterman decided to study why these mice had systemic lupus–like disease. At the time, follicular B helper T cells (Tfh) started attracting considerable research interest. Tfh are critical for germinal centre formation, and mice in Linterman's lab (with the Roquinsan/sansanroque mutation) spontaneously formed Tfh cells that contributed to the systemic lupus erythematosus that plagued these mice. [1] [3] She discovered that a proportion of these Tfh cells expressed FOXP3, a transcription factor involved in immune system responses. [1]

Linterman moved to the University of Cambridge as a postdoctoral researcher, where she studied the fundamental biology of Tfh cells. [4] [5] Still fascinated by the mechanisms that underpin FOXP3 regulation, Linterman started exploring Tfh cells in vivo. [6]

Research and career

Linterman formed a research group at the Babraham Institute, where she studies germinal centre biology and how the immune system responds to vaccination. [7] [8] Germinal centres are sites within biological tissue (e.g. in the spleen, tonsils and lymph nodes) where B cells reproduce, replicate and differentiate as the immune system responds to infection. The germinal centre teaches the immune system how to respond more rapidly and effectively to future pathogens, and is critical for effective response to vaccination. The magnitude of the germinal centre response diminishes with age, largely due to the role of T cells. [9] Linterman investigates the role of the germinal centre in ageing, and how they form non-lymphoid tissues. [10] She found that a cascade of events creates germinal centres that help to create cross-reactive antibodies. [11]

In 2019, Linterman was awarded the Lister Institute Research Prize Fellowship for her efforts to understand the flu infection. [11] [12] She discovered that the body remodels lung tissue to contribute to the immune system response and produce more antibodies. [11]

Selected publications

References

  1. 1 2 3 4 Van Emmenis, Lucie (12 June 2023). "Michelle Linterman: We are always learning". Journal of Experimental Medicine. 220 (7) e20230900. doi:10.1084/jem.20230900. ISSN   0022-1007. PMC   10258648 . PMID   37306687.
  2. "Roll of graduates". Victoria University of Wellington. November 2023. Retrieved 6 March 2024.
  3. Linterman, Michelle A.; Rigby, Robert J.; Wong, Raphael. K.; Yu, Di; Brink, Robert; Cannons, Jennifer L.; Schwartzberg, Pamela L.; Cook, Matthew C.; Walters, Giles D.; Vinuesa, Carola G. (16 March 2009). "Follicular helper T cells are required for systemic autoimmunity". Journal of Experimental Medicine. 206 (3): 561–576. doi:10.1084/jem.20081886. ISSN   1540-9538. PMC   2699132 . PMID   19221396.
  4. Linterman, Michelle A; Denton, Alice E; Divekar, Devina P; Zvetkova, Ilona; Kane, Leanne; Ferreira, Cristina; Veldhoen, Marc; Clare, Simon; Dougan, Gordon; Espéli, Marion; Smith, Kenneth GC (27 October 2014). "CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection". eLife. 3 e03180. doi: 10.7554/eLife.03180 . ISSN   2050-084X. PMC   4241536 . PMID   25347065.
  5. "Dr Michelle Linterman". Churchill College. Retrieved 5 March 2024.
  6. Linterman, Michelle A; Pierson, Wim; Lee, Sau K; Kallies, Axel; Kawamoto, Shimpei; Rayner, Tim F; Srivastava, Monika; Divekar, Devina P; Beaton, Laura; Hogan, Jennifer J; Fagarasan, Sidonia; Liston, Adrian; Smith, Kenneth G C; Vinuesa, Carola G (August 2011). "Foxp3+ follicular regulatory T cells control the germinal center response". Nature Medicine. 17 (8): 975–982. doi:10.1038/nm.2425. ISSN   1078-8956. PMC   3182542 . PMID   21785433.
  7. "Michelle Linterman | Babraham Institute". www.babraham.ac.uk. Retrieved 4 March 2024.
  8. "Our Stories: Michelle Linterman". www.nzwomen.co.uk. Retrieved 5 March 2024.
  9. "Linterman lab at Babraham Institute uncovers reasons why our vaccine response declines with age". Cambridge Independent. 25 May 2023. Retrieved 5 March 2024.
  10. "Michelle Linterman » Babraham Institute". www.babraham.ac.uk. Retrieved 5 March 2024.
  11. 1 2 3 "Dr Michelle Linterman at Babraham Institute wins £250,000 Lister Prize for work on flu infection". Cambridge Independent. 14 July 2019. Retrieved 5 March 2024.
  12. "Fellow Profile: Dr Michelle Linterman". Lister Institute. 12 December 2019. Retrieved 5 March 2024.