MicroRNA 375

MIR375
Identifiers
Aliases	MIR375 , MIRN375, hsa-mir-375, miRNA375, mir-375, microRNA 375
External IDs	OMIM: 611173 GeneCards: MIR375
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,001,708 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; blood; ; monocyte; ; placenta; ; stomach; ; transverse colon; ; right lobe of thyroid gland; ; minor salivary gland; ; body of stomach; ; diencephalon;
	n/a
	More reference expression data
	n/a
Orthologs
	494324
	n/a
	ENSG00000198973
	n/a
	n ; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated December 31, 2023

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzymes to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Related Research Articles

The miR-9 microRNA, is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.

The miR-29 microRNA precursor, or pre-miRNA, is a small RNA molecule in the shape of a stem-loop or hairpin. Each arm of the hairpin can be processed into one member of a closely related family of short non-coding RNAs that are involved in regulating gene expression. The processed, or "mature" products of the precursor molecule are known as microRNA (miRNA), and have been predicted or confirmed in a wide range of species.

In molecular biology mir-126 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several pre- and post-transcription mechanisms.

In molecular biology mir-605 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

MicroRNA 7-1 is a microRNA molecule that in humans is encoded by the MIR7-1 gene.

MicroRNA 138-1 is a protein that in humans is encoded by the MIR138-1 gene.

MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene.

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene.

MicroRNA 499a is a non-coding RNA that in humans is encoded by the MIR499A gene.

MicroRNA let-7f-2 is a protein that in humans is encoded by the MIRLET7F2 gene.

MicroRNA 106a is a microRNA that in humans is encoded by the MIR106A gene.

MicroRNA 495 is a protein that in humans is encoded by the MIR495 gene.

MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene.

MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C gene.

MicroRNA 195 is a protein that in humans is encoded by the MIR195 gene.

MicroRNA 885 is a protein that in humans is encoded by the MIR885 gene.

MicroRNA 210 is a protein that in humans is encoded by the MIR210 gene.

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene.

MicroRNA 124-3 is a protein that in humans is encoded by the MIR124-3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198973 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MicroRNA 375" . Retrieved 2018-04-16.

Liu AM, Poon RT, Luk JM (April 2010). "MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties". Biochem. Biophys. Res. Commun. 394 (3): 623–7. doi:10.1016/j.bbrc.2010.03.036. PMID 20226166.
Zhao H, Guan J, Lee HM, Sui Y, He L, Siu JJ, Tse PP, Tong PC, Lai FM, Chan JC (August 2010). "Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition". Pancreas. 39 (6): 843–6. doi:10.1097/MPA.0b013e3181d12613. PMID 20467341. S2CID 23458178.
Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J, Zhou T (July 2010). "MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2". Cell Res. 20 (7): 784–93. doi: 10.1038/cr.2010.79 . PMID 20548334.
de Souza Rocha Simonini P, Breiling A, Gupta N, Malekpour M, Youns M, Omranipour R, Malekpour F, Volinia S, Croce CM, Najmabadi H, Diederichs S, Sahin O, Mayer D, Lyko F, Hoheisel JD, Riazalhosseini Y (November 2010). "Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells". Cancer Res. 70 (22): 9175–84. doi: 10.1158/0008-5472.CAN-10-1318 . PMID 20978187.
Zhang X, Yan Z, Zhang J, Gong L, Li W, Cui J, Liu Y, Gao Z, Li J, Shen L, Lu Y (October 2011). "Combination of hsa-miR-375 and hsa-miR-142-5p as a predictor for recurrence risk in gastric cancer patients following surgical resection". Ann. Oncol. 22 (10): 2257–66. doi: 10.1093/annonc/mdq758 . PMID 21343377.
Li X, Lin R, Li J (October 2011). "Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer". Dig. Dis. Sci. 56 (10): 2849–56. doi:10.1007/s10620-011-1711-1. PMID 21533613. S2CID 29745421.
Szczyrba J, Nolte E, Wach S, Kremmer E, Stöhr R, Hartmann A, Wieland W, Wullich B, Grässer FA (June 2011). "Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma". Mol. Cancer Res. 9 (6): 791–800. doi: 10.1158/1541-7786.MCR-10-0573 . PMID 21593139.
Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Morimura R, Nagata H, Kosuga T, Iitaka D, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E (June 2011). "Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma". Br. J. Cancer. 105 (1): 104–11. doi:10.1038/bjc.2011.198. PMC 3137413 . PMID 21673684.
Mazar J, DeBlasio D, Govindarajan SS, Zhang S, Perera RJ (August 2011). "Epigenetic regulation of microRNA-375 and its role in melanoma development in humans". FEBS Lett. 585 (15): 2467–76. doi: 10.1016/j.febslet.2011.06.025 . PMID 21723283. S2CID 15319974.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198973 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 375" . Retrieved 2018-04-16.

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[2]

[3]

MicroRNA 375

Contents

Function

Related Research Articles

References

Further reading