Mikala Egeblad | |
|---|---|
| Alma mater | University of Copenhagen |
| Scientific career | |
| Thesis | ErbB receptors and ligands in breast cancer (1999) |
| Doctoral advisor | Zena Werb |
Mikala Egeblad is a Bloomburg Distinguished Professor at Johns Hopkins School of Medicine. She is known for her research into cancer, and how it spreads in humans.
Egeblad attended the University of Copenhagen where she earned a bachelor’s degree in medicine, a master’s degree in human biology and a Ph.D. in cancer biology. Following her PhD, she trained as a postdoctoral fellow at University of California, San Francisco [1] where she worked with Zena Werb. [2] In 2009, she established her own lab at Cold Spring Harbor Laboratory where she worked until moving to Johns Hopkins School of Medicine as a Bloomberg Distinguished Professor in 2023. [1]
Egeblad's research is centered on understanding how the body’s immune response influences cancer progression, metastasis, and therapy outcomes. While at the University of California, San Francisco, Egeblad used mouse models to research the cancerous tumor microenvironment, focusing on the contribution of the innate immune system and matrix metalloproteinases. [3] Egeblad also co-developed a technique of intravital imaging, using a 2-photon microscope and silicone window implant to capture immune cell behavior in real time. [4] [5]
After she moved to Cold Spring Harbor she continued to study the tumor microenvironment, foscusing on the interactions between cancer cells and their surrounding stromal cells. [6] Her work has helped define the mechanisms by which neutrophils induce the progression of cancer and its metastasis. [7]
In 2017 Egeblad received the Pershing Square Sohn Prize from the Sohn Conference Foundation. [8] She received the Suffrage Science award from her mentor Marja Jäättelä in 2018. [9] [10]