Mimi Hii

Last updated
Mimi Hii
Born
King Kuok Hii

(1969-12-23) 23 December 1969 (age 54)
Alma materUniversity of Leeds
Known forStudy of Catalysis and Rapid Analysis
Scientific career
FieldsChemistry
Institutions Imperial College London
Doctoral advisor Bernard L. Shaw

King Kuok "Mimi" Hii (born 23 December 1969) is a chemist whose fields of research include application of catalysis to organic synthesis. She is the Director of Imperial College London's Centre for Rapid Online Analysis of Reactions (ROAR). [1]

Contents

Academic career

Hii studied for both her BSc and PhD at The University of Leeds investigating multidentate ligand metal complexes under the supervision of Bernard L. Shaw. [2] Postdoctoral studies at Oxford University in John M. Brown's group were followed by independent research at University of Leeds, King's College London and in Imperial College London. [3] In 2016 she was awarded a Professorship in Catalysis and in 2018 became the Director of the Centre for Rapid Online Analysis of Reactions. [4]

Research interests

Hii has investigated catalysis during her research career. In Oxford, she characterised intermediates of the Heck reaction. [5] Hii also studied this reaction at King's College London. [6] Hii has continued with this field of study producing over a hundred articles, reviews, book chapters and patents. These include articles, reviews and books on sustainable chemistry methods. [7] [8] [9] [10] In 2010 Hii joined the Steering Group of the Engineering and Physical Sciences Research Council Dial-a-Molecule Grand Challenge network and became a Co-Investigator on phase III of the project in 2016. [11] Hii has been awarded many grants, most notably a multi-million award from the Engineering and Physical Sciences Research Council in 2017 which, together with money from Imperial College London and industrial partners funded the set up of Imperial College London's Centre for Rapid Online Analysis of Reactions (ROAR). [12] [4]

Awards and honours

In 2013, the Federation of Asian Chemistry Societies recognised Hii as an Asian Rising Star. Hii was also elected as a Fellow of the Royal Society of Chemistry. [13] In 2016 Hii became co-editor in chief of the open access Chemistry Central Journal. [14] In 2019 Mimi Hii was shortlisted for an Asian Women of Achievement Award. [15]

Related Research Articles

<span class="mw-page-title-main">Catalysis</span> Process of increasing the rate of a chemical reaction

Catalysis is the increase in rate of a chemical reaction due to an added substance known as a catalyst. Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quickly, very small amounts of catalyst often suffice; mixing, surface area, and temperature are important factors in reaction rate. Catalysts generally react with one or more reactants to form intermediates that subsequently give the final reaction product, in the process of regenerating the catalyst.

The Heck reaction is the chemical reaction of an unsaturated halide with an alkene in the presence of a base and a palladium catalyst to form a substituted alkene. It is named after Tsutomu Mizoroki and Richard F. Heck. Heck was awarded the 2010 Nobel Prize in Chemistry, which he shared with Ei-ichi Negishi and Akira Suzuki, for the discovery and development of this reaction. This reaction was the first example of a carbon-carbon bond-forming reaction that followed a Pd(0)/Pd(II) catalytic cycle, the same catalytic cycle that is seen in other Pd(0)-catalyzed cross-coupling reactions. The Heck reaction is a way to substitute alkenes.

In organic chemistry, a coupling reaction is a type of reaction in which two reactant molecules are bonded together. Such reactions often require the aid of a metal catalyst. In one important reaction type, a main group organometallic compound of the type R-M reacts with an organic halide of the type R'-X with formation of a new carbon-carbon bond in the product R-R'. The most common type of coupling reaction is the cross coupling reaction.

Reductive amination is a form of amination that involves the conversion of a carbonyl group to an amine via an intermediate imine. The carbonyl group is most commonly a ketone or an aldehyde. It is a common method to make amines and is widely used in green chemistry since it can be done catalytically in one-pot under mild conditions. In biochemistry, dehydrogenase enzymes use reductive amination to produce the amino acid, glutamate. Additionally, there is ongoing research on alternative synthesis mechanisms with various metal catalysts which allow the reaction to be less energy taxing, and require milder reaction conditions. Investigation into biocatalysts, such as imine reductases, have allowed for higher selectivity in the reduction of chiral amines which is an important factor in pharmaceutical synthesis.

The Negishi coupling is a widely employed transition metal catalyzed cross-coupling reaction. The reaction couples organic halides or triflates with organozinc compounds, forming carbon-carbon bonds (C-C) in the process. A palladium (0) species is generally utilized as the metal catalyst, though nickel is sometimes used. A variety of nickel catalysts in either Ni0 or NiII oxidation state can be employed in Negishi cross couplings such as Ni(PPh3)4, Ni(acac)2, Ni(COD)2 etc.

<span class="mw-page-title-main">Richard F. Heck</span> American chemist (1931–2015)

Richard Frederick Heck was an American chemist noted for the discovery and development of the Heck reaction, which uses palladium to catalyze organic chemical reactions that couple aryl halides with alkenes. The analgesic naproxen is an example of a compound that is prepared industrially using the Heck reaction.

<span class="mw-page-title-main">1,3-Bis(diphenylphosphino)propane</span> Chemical compound

1,3-Bis(diphenylphosphino)propane (dppp) is an organophosphorus compound with the formula Ph2P(CH2)3PPh2. The compound is a white solid that is soluble in organic solvents. It is slightly air-sensitive, degrading in air to the phosphine oxide. It is classified as a diphosphine ligand in coordination chemistry and homogeneous catalysis.

In organic chemistry, a cross-coupling reaction is a reaction where two different fragments are joined. Cross-couplings are a subset of the more general coupling reactions. Often cross-coupling reactions require metal catalysts. One important reaction type is this:

<span class="mw-page-title-main">Phosphinooxazolines</span>

Phosphinooxazolines are a class of chiral ligands used in asymmetric catalysis. Their complexes are particularly effective at generating single enatiomers in reactions involving highly symmetric transition states, such as allylic substitutions, which are typically difficult to perform stereoselectively. The ligands are bidentate and have been shown to be hemilabile with the softer P‑donor being more firmly bound than the harder N‑donor.

Martin Schröder in an inorganic chemist. He is Vice President and Dean for the Faculty of Science and Engineering and Professor of Chemistry in the Department of Chemistry at the University of Manchester since June 2015. He served previously as Executive Dean of the Faculty of Science from 2011 to 2015 and Professor of Inorganic Chemistry at the University of Nottingham from 1995 to 2015.

<span class="mw-page-title-main">Catellani reaction</span>

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<span class="mw-page-title-main">Tom Welton</span>

Thomas Welton is a professor of sustainable chemistry at Imperial College London. He served as head of the department of chemistry from 2007 to 2014 and as dean of the faculty of natural sciences from 2015 to 2019. He is a Fellow and the current president of the Royal Society of Chemistry. Welton's research focuses on sustainable chemistry, with particular focus on ionic liquids and on solvent effects on chemical reactions. Welton is openly gay and is active in advocating for greater visibility for members of the LGBT community in the sciences. He is a member of the UKRI Equality, Diversity and Inclusion External Advisory Group.

<span class="mw-page-title-main">Department of Chemistry, Imperial College London</span>

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Donna Blackmond is an American chemical engineer and the John C. Martin Endowed Chair in Chemistry at Scripps Research in La Jolla, CA. Her research focuses on prebiotic chemistry, the origin of biological homochirality, and kinetics and mechanisms of asymmetric catalytic reactions. Notable works include the development of Reaction Progress Kinetic Analysis (RPKA), analysis of non-linear effects of catalyst enantiopurity, biological homochirality and amino acid behavior.

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In organic chemistry, the Fujiwara–Moritani reaction is a type of cross coupling reaction where an aromatic C-H bond is directly coupled to an olefinic C-H bond, generating a new C-C bond. This reaction is performed in the presence of a transition metal, typically palladium. The reaction was discovered by Yuzo Fujiwara and Ichiro Moritani in 1967. An external oxidant is required to this reaction to be run catalytically. Thus, this reaction can be classified as a C-H activation reaction, an oxidative Heck reaction, and a C-H olefination. Surprisingly, the Fujiwara–Moritani reaction was discovered before the Heck reaction.

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Heterogeneous metal catalyzed cross-coupling is a subset of metal catalyzed cross-coupling in which a heterogeneous metal catalyst is employed. Generally heterogeneous cross-coupling catalysts consist of a metal dispersed on an inorganic surface or bound to a polymeric support with ligands. Heterogeneous catalysts provide potential benefits over homogeneous catalysts in chemical processes in which cross-coupling is commonly employed—particularly in the fine chemical industry—including recyclability and lower metal contamination of reaction products. However, for cross-coupling reactions, heterogeneous metal catalysts can suffer from pitfalls such as poor turnover and poor substrate scope, which have limited their utility in cross-coupling reactions to date relative to homogeneous catalysts. Heterogeneous metal catalyzed cross-couplings, as with homogeneous metal catalyzed ones, most commonly use Pd as the cross-coupling metal.

References

  1. ↑ "Centre for Rapid Online Analysis of Reactions (ROAR)". Imperial College London. Retrieved 2019-05-06.
  2. ↑ Shaw, Bernard L.; Perera, Sarath D.; Hii, King Kuok (1994-01-01). "Terdentate (P–N–O) complexes formed from Z,E-PPh2CH2C-(But)N–NCH(C6H4OH-2) or Z,E-PPh2CH2C(But)N–NCH-[C6H2(OH-2)(OMe)2-4,6] and nickel, palladium, platinum, rhodium or iridium". Journal of the Chemical Society, Dalton Transactions (24): 3589–3596. doi:10.1039/DT9940003589. ISSN   1364-5447.
  3. ↑ "Chemistry Tree - King Kuok (Mimi) Hii Family Tree". academictree.org. Retrieved 2019-05-06.
  4. 1 2 "First-of-its-kind automatic chemistry facility opens at Imperial | Imperial News | Imperial College London". Imperial News. Retrieved 2019-05-06.
  5. ↑ Brown, John M.; Hii, King Kuok (Mimi) (1996). "Characterization of Reactive Intermediates in Palladium-Catalyzed Arylation of Methyl Acrylate (Heck Reaction)". Angewandte Chemie International Edition in English. 35 (6): 657–659. doi:10.1002/anie.199606571. ISSN   1521-3773.
  6. ↑ Qadir, Maryiam; Möchel, Tobias; (Mimi) Hii, King Kuok (2000-09-29). "Examination of Ligand Effects in the Heck Arylation Reaction". Tetrahedron. 56 (40): 7975–7979. doi:10.1016/S0040-4020(00)00703-1.
  7. ↑ Dunn, Peter J.; Hii, K. K. Mimi; Krische, Michael J.; Williams, Michael T., eds. (2013-04-08). Sustainable Catalysis. doi:10.1002/9781118354520. ISBN   9781118354520.
  8. ↑ Leung, Andrew Yuk Keung; Hellgardt, Klaus; Hii, King Kuok “Mimi” (2018-04-02). "Catalysis in Flow: Nickel-Catalyzed Synthesis of Primary Amines from Alcohols and NH3". ACS Sustainable Chemistry & Engineering. 6 (4): 5479–5484. doi:10.1021/acssuschemeng.8b00338. hdl: 10044/1/57850 .
  9. ↑ Hii, King Kuok (Mimi); Hellgardt, Klaus; Mulligan, Christopher J.; Adrio, Luis A.; Emmerich, Herman; Parry, Stephen; Barreiro, Elena M.; Brazier, John B.; Newton, Mark A. (2016-01-18). "Operando XAFS of supported Pd nanoparticles in flowing ethanol/water mixtures: implications for catalysis". Green Chemistry. 18 (2): 406–411. doi: 10.1039/C5GC01600B . hdl: 10044/1/25721 . ISSN   1463-9270.
  10. ↑ Mulligan, Christopher J.; Bagale, Sharanappa M.; Newton, Oliver J.; Parker, Jeremy S.; Hii, King Kuok Mimi (2019-01-07). "Peracetic Acid: An Atom-Economical Reagent for Pd-Catalyzed Acetoxylation of C–H Bonds". ACS Sustainable Chemistry & Engineering. 7 (1): 1611–1615. doi:10.1021/acssuschemeng.8b05370. hdl: 10044/1/66751 . S2CID   104432879.
  11. ↑ "People – Phase III". Dial-a-Molecule EPSRC Grand Challenge Network Website. 2017-01-10. Retrieved 2019-05-06.
  12. ↑ author, EPSRC. "Grants on the web". gow.epsrc.ukri.org. Retrieved 2019-05-06.{{cite web}}: |last= has generic name (help)
  13. ↑ "Dr. King Kuok (Mimi) Hii". King Kuok Hii Lab, Imperial College London. Retrieved 6 May 2019.
  14. ↑ Hollingworth, Charlotte (2016-02-03). "New Co-Editor-in-Chief for Chemistry Central Journal". SpringerOpen blog. Retrieved 2019-05-06.
  15. ↑ "2019". Asian Women of Achievement Awards. Retrieved 2019-05-06.
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