Mir-449 microRNA precursor family

miR-449
Identifiers
Symbol	miR-449
Rfam	RF00711
miRBase family	MIPF0000133
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology, microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed. ^[1] This miR-449 family belongs to the miR-34/miR-449 superfamily of microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c. ^{[1] [2]} They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates. ^{[1] [2]}

See also

• MicroRNA

References

1. Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P. (2011). ""Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway"". Nature Cell Biology . 13 (6): 693–9. doi:10.1038/ncb2241. PMID   21602795. S2CID   11514412.
2. Ioannis Loukas, Margarita Skamnelou , Stavroula Tsaridou , Spyridoula Bournaka, Sokratis Grigoriadis, Stavros Taraviras, Zoi Lygerou and Marina Arbi (2021). "Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members". Biological Reviews . 96 (5): 2321–2332. doi:10.1111/brv.12755. PMID   34132477. S2CID   235449908.

Further reading

• Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F, Skawran B (September 2012). "Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells". Gastroenterology. 143 (3): 811–820.e15. doi:10.1053/j.gastro.2012.05.033. PMID   22641068.
• Bao J, Li D, Wang L, Wu J, Hu Y, Wang Z, Chen Y, Cao X, Jiang C, Yan W, Xu C (June 2012). "MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway". The Journal of Biological Chemistry. 287 (26): 21686–98. doi: 10.1074/jbc.M111.328054 . PMC   3381132 . PMID   22570483.
• Ma YY, Tao HQ (April 2012). "Microribonucleic acids and gastric cancer". Cancer Science. 103 (4): 620–5. doi: 10.1111/j.1349-7006.2011.02185.x . PMC   7713626 . PMID   22168593.
• Lizé M, Klimke A, Dobbelstein M (September 2011). "MicroRNA-449 in cell fate determination" (PDF). Cell Cycle. 10 (17): 2874–82. doi: 10.4161/cc.10.17.17181 . hdl:11858/00-001M-0000-000F-00E9-4. PMID   21857159.
• Marcet B, Chevalier B, Coraux C, Kodjabachian L, Barbry P (September 2011). "MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation". Cell Cycle. 10 (17): 2858–64. doi: 10.4161/cc.10.17.17011 . PMID   21857154.
• Buechner J, Tømte E, Haug BH, Henriksen JR, Løkke C, Flægstad T, Einvik C (July 2011). "Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma". British Journal of Cancer. 105 (2): 296–303. doi:10.1038/bjc.2011.220. PMC   3142803 . PMID   21654684.
• Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P (June 2011). "Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway". Nature Cell Biology. 13 (6): 693–9. doi:10.1038/ncb2241. PMID   21602795. S2CID   11514412.
• Chevalier B, Adamiok A, Mercey O, Revinski DR, Zaragosi LE, Pasini A, Kodjabachian L, Barbry P, Marcet B (September 2015). ""miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways"". Nature Communications. 18 (6): 8386. Bibcode:2015NatCo...6.8386C. doi: 10.1038/ncomms9386 . PMC   4595761 . PMID   26381333.
• Mercey O, Popa A, Cavard A, Paquet A, Chevalier B, Pons N, Magnone V, Zangari J, Brest P, Zaragosi LE, Ponzio G, Lebrigand K, Barbry P, Marcet B (March 2017). ""Characterizing isomiR variants within the microRNA-34/449 family"". FEBS Letters. 591 (5): 693–705. doi: 10.1002/1873-3468.12595 . PMC   5363356 . PMID   28192603.
• Mercey O, Chevalier, B, Kodjabachian L, Barbry P, Marcet B (December 2015). ""MicroRNAs pull the strings of motile cilia (Des microARN au Coeur de la fabrication des cils motiles)"". Médecine/Sciences. 31 (12): 1078–1080. doi: 10.1051/medsci/20153112010 . PMID   26672659.
• Mercey O, Kodjabachian L, Barbry P, Marcet B (2016). ""MicroRNAs as new regulators of GTPase-mediated apical actin reorganization in multiciliated epithelia"". Journal of Small GTPases. 7 (2): 54–8. doi:10.1080/21541248.2016.1151099. PMC   4905265 . PMID   27144998.
• Bou Kheir T, Futoma-Kazmierczak E, Jacobsen A, Krogh A, Bardram L, Hother C, Grønbæk K, Federspiel B, Lund AH, Friis-Hansen L (March 2011). "miR-449 inhibits cell proliferation and is down-regulated in gastric cancer". Molecular Cancer. 10: 29. doi: 10.1186/1476-4598-10-29 . PMC   3070685 . PMID   21418558.
• Ma L, Li N, He X, Zhang Q (February 2011). "[miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line]". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences. 43 (1): 129–33. PMID   21321636.
• Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, Shen SR (December 2010). "Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells". Molecular and Cellular Biochemistry. 345 (1–2): 283–90. doi:10.1007/s11010-010-0582-7. PMID   20859756. S2CID   27292546.
• Feng M, Yu Q (January 2010). "miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit". Cell Cycle. 9 (2): 213–4. doi: 10.4161/cc.9.2.10502 . PMID   20046097.
• Campanini ML, Colli LM, Paixao BM, Cabral TP, Amaral FC, Machado HR, Neder LS, Saggioro F, Moreira AC, Antonini SR, de Castro M (August 2010). "CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas". Hormones & Cancer. 1 (4): 187–96. doi: 10.1007/s12672-010-0041-7 . PMC   10358030 . PMID   21761366.
• Lizé M, Pilarski S, Dobbelstein M (March 2010). "E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis". Cell Death and Differentiation. 17 (3): 452–8. doi: 10.1038/cdd.2009.188 . hdl: 11858/00-001M-0000-0011-E2F8-7 . PMID   19960022.
• Greco S, De Simone M, Colussi C, Zaccagnini G, Fasanaro P, Pescatori M, Cardani R, Perbellini R, Isaia E, Sale P, Meola G, Capogrossi MC, Gaetano C, Martelli F (October 2009). "Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia". FASEB Journal. 23 (10): 3335–46. doi: 10.1096/fj.08-128579 . PMID   19528256. S2CID   36872281.
• Iliopoulos D, Bimpaki EI, Nesterova M, Stratakis CA (April 2009). "MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling". Cancer Research. 69 (8): 3278–82. doi:10.1158/0008-5472.CAN-09-0155. PMC   3124768 . PMID   19351815.
• Wu W, Lin Z, Zhuang Z, Liang X (February 2009). "Expression profile of mammalian microRNAs in endometrioid adenocarcinoma". European Journal of Cancer Prevention. 18 (1): 50–5. doi:10.1097/CEJ.0b013e328305a07a. PMID   19077565. S2CID   205549917.

External links

• Page for mir-449 microRNA precursor family at Rfam