Mir-592 microRNA precursor family

Last updated
mir-592
Identifiers
Symbolmir-592
Rfam RF00877
miRBase family MIPF0000340
Other data
RNA type microRNA
Domain Eukaryota;
PDB structures PDBe

In molecular biology mir-592 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Contents

Expression in cancers

Significantly altered expression of miR-592 has been observed between tumours deficient and proficient for mismatch repair in colon cancer. [1] Expression levels are lower in the proficient form compared to the deficient, with a more than two-fold change. [2] This altered expression has been proposed to reflect a reversion to regulatory programs seen in earlier undifferentiated and proliferative developmental states.

miR-592 expression is also altered in hepatocellular carcinoma; it has been shown to be downregulated along with nine other microRNAs.

See also

References

  1. ↑ Sarver AL, French AJ, Borralho PM, Thayanithy V, Oberg AL, Silverstein KA, et al. (2009). "Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states". BMC Cancer. 9: 401. doi: 10.1186/1471-2407-9-401 . PMC   2787532 . PMID   19922656.
  2. ↑ Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, et al. (2011). "miRNA expression in colon polyps provides evidence for a multihit model of colon cancer". PLOS ONE. 6 (6) e20465. Bibcode:2011PLoSO...620465O. doi: 10.1371/journal.pone.0020465 . PMC   3111419 . PMID   21694772.

Further reading


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