mir-650 | |
---|---|
Identifiers | |
Symbol | mir-650 |
Rfam | RF00952 |
miRBase family | MIPF0000457 |
Other data | |
RNA type | microRNA |
Domain(s) | Eukaryota; |
PDB structures | PDBe |
In molecular biology mir-650 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-650 is one of a group of six miRNAs with altered expression levels in diabetic and non-diabetic heart failure. This altered expression corresponds to various enriched cardiac dysfunctions. [1]
miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene. [2] There is direct regulation of this gene at a transcriptional level, leading to repressed NDRG2 expression.
The miR-1 microRNA precursor is a small micro RNA that regulates its target protein's expression in the cell. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give products at ~22 nucleotides. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In humans there are two distinct microRNAs that share an identical mature sequence, and these are called miR-1-1 and miR-1-2.
In molecular biology mir-126 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several pre- and post-transcription mechanisms.
In molecular biology mir-22 microRNA is a short RNA molecule. MicroRNAs are an abundant class of molecules, approximately 22 nucleotides in length, which can post-transcriptionally regulate gene expression by binding to the 3' UTR of mRNAs expressed in a cell.
miR-27 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-27 precursor is the microRNA mir-27.
In molecular biology mir-301 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
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In molecular biology mir-370 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. This microRNA, mir-370-3p, has been shown to play a role in heart failure. The upregulation of mir-370-3p in the sinus node leads to downregulation of the pacemaker ion channel, HCN4, and thus downregulation of the corresponding ionic current, which causes sinus bradycardia.
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In molecular biology mir-25 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human heart failure, and treatment with an anti-sense RNA molecule (antagomiR) was recently reported to halt disease progression and improves cardiac function in a mouse heart failure model.
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