Mir-652 microRNA precursor family

mir-652
Identifiers
Symbol	mir-652
Rfam	RF00872
miRBase family	MIPF0000333
Other data
RNA type	microRNA
Domain	Eukaryota;
PDB structures	PDBe

In molecular biology mir-652 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, with expression levels of miRNAs and respective target mRNAs negatively correlated.

Lineage

miR-652 expression is specific to cells of the myeloid lineage, in this instance to monocytes and granulocytes. ^[1]

miR-652 and liver cirrhosis

miR-652 serum levels are significantly altered in alcoholic- or hepatitis-C-induced liver cirrhosis patients. They have been found to be down-regulated in the circulating monocytes of such patients, thus supporting the idea of an miR-652 role in the mediation of fibrogenic and inflammatory processes in the pathogenesis of liver cirrhosis. ^[2]

Expression in liver cancer

Circulating levels of miR-652 show gradual elevation with progression of liver cancer, as is also the case with miRNAs let-7a, let-7f, miR-34a, miR-98, miR-331 and miR-338. ^[3]

See also

• MicroRNA

References

1. Allantaz F, Cheng DT, Bergauer T, Ravindran P, Rossier MF, Ebeling M, et al. (2012). "Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression". PLOS ONE. 7 (1) e29979. Bibcode:2012PLoSO...729979A. doi: 10.1371/journal.pone.0029979 . PMC   3262799 . PMID   22276136.
2. Roderburg C, Mollnow T, Bongaerts B, Elfimova N, Vargas Cardenas D, Berger K, et al. (2012). "Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis". PLOS ONE. 7 (3) e32999. Bibcode:2012PLoSO...732999R. doi: 10.1371/journal.pone.0032999 . PMC   3296762 . PMID   22412969.
3. Sukata T, Sumida K, Kushida M, Ogata K, Miyata K, Yabushita S, Uwagawa S (January 2011). "Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages". Toxicology Letters. 200 (1–2): 46–52. doi:10.1016/j.toxlet.2010.10.013. PMID   21035526.

Further reading

• Lulla RR, Costa FF, Bischof JM, Chou PM, de F Bonaldo M, Vanin EF, Soares MB (2011). "Identification of Differentially Expressed MicroRNAs in Osteosarcoma". Sarcoma. 2011 732690. doi: 10.1155/2011/732690 . PMC   3140035 . PMID   21789031.
• Lai CY, Yu SL, Hsieh MH, Chen CH, Chen HY, Wen CC, Huang YH, Hsiao PC, Hsiao CK, Liu CM, Yang PC, Hwu HG, Chen WJ (2011). Uddin M (ed.). "MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia". PLOS ONE. 6 (6) e21635. Bibcode:2011PLoSO...621635L. doi: 10.1371/journal.pone.0021635 . PMC   3126851 . PMID   21738743.
• Santarelli DM, Beveridge NJ, Tooney PA, Cairns MJ (January 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry. 69 (2): 180–7. doi:10.1016/j.biopsych.2010.09.030. hdl: 1959.13/934011 . PMID   21111402. S2CID   33340677.
• Gao W, Shen H, Liu L, Xu J, Xu J, Shu Y (April 2011). "MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis". Journal of Cancer Research and Clinical Oncology. 137 (4): 557–66. doi:10.1007/s00432-010-0918-4. PMC   11828261 . PMID   20508945. S2CID   5744114.

External links

• Page for mir-652 microRNA precursor family at Rfam