| mir-708 | |
|---|---|
| Identifiers | |
| Symbol | mir-708 |
| Rfam | RF00917 |
| miRBase family | MIPF0000397 |
| Other data | |
| RNA type | microRNA |
| Domain | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene. [1] It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye. [2]
miR-708 has been implicated in the bone-specific Ewing's sarcoma. Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, which in turn is via repression of miR-708. [3] miR-708 targets the 3'UTR of EYA3, rather than binding directly to its promoter region. High levels of EYA3 in Ewing's sarcoma are accordingly correlated with low levels of miR-708.
High miR-708 expression levels are observed in lung cancers due to their oncogenic role in lung cancer tumour growth and progression. miR-708 overexpression results in increased cell proliferation, migration, and invasion, and has therefore been associated with a decreased survival rate in lung epithelial cancers. It directly downregulates the transmembrane protein 88 (TMEM88), a negative regulator of the Wnt signalling pathway. [4]