Miratul Muqit

Last updated

Miratul Muqit
Born1973
Glasgow, Scotland
Alma materUniversity of Edinburgh, Harvard University, University College London
Occupation(s)Consultant Neurologist, Professor
OrganizationUniversity of Dundee
Known forContributions to the study of PINK1 in Parkinson’s disease
Website https://www.ppu.mrc.ac.uk/research/principal-investigator/miratul-muqit

Miratul Muqit FRSE [1] FMedSci is a British neurologist and a Programme Lead at the MRC Protein Phosphorylation and Ubiquitylation Unit (MRCPPU) in the School of Life Sciences at the University of Dundee. [2] His research focuses on the study of the PINK1 gene, mutations in which are a major cause of Parkinson's disease. [2] [3]

Contents

Education and career

Muqit studied medicine at the University of Edinburgh and graduated with Honours in 1997. [4] During his studies he became interested in neurodegenerative diseases, and in 2000 he was awarded a Kennedy scholarship [5] at Harvard University which he completed within a year of study. [6] His interest in neurodegeneration led him to study for a PhD in University College London’s Institute of Neurology, awarded to him in 2007. [7] [8] [9]

He also received clinical training in medicine and neurology at the Hammersmith Hospital and the National Hospital for Neurology and Neurosurgery in London. [7] [8]

He joined the MRC PPU at the University of Dundee in 2008 and has worked there since combining laboratory research and clinical work as a Consultant Neurologist specialising in Movement Disorders. [7] [8] [10] He was appointed Professor of Experimental Neurology in October 2018. [11]

Research

Muqit's research focuses on the protein PINK1, study of which he began during his PhD in UCL. He is credited as a major contributor to the discovery of PINK1 mutations as a cause of Parkinson's disease, and he has been working on it ever since. [7] [10] [12]

PINK1 is a kinase which normally senses damaged mitochondria and targets them for destruction, and mutations which interrupt its function will induce Parkinson's disease. Much of his research focuses on characterising PINK1 to understand its signalling pathway and the effects of it and its mutations on the cell, in order to help find treatments for Parkinson's Disease. [2] [10] [13]

His research team at the university of Dundee has already discovered substrates of PINK1 such as Parkin and Ubiquitin, which have helped to clarify the function of this kinase. They have also made an effort to understand the mechanisms of activation and regulation of PINK1. [3]

Impact

Muqit's research on Parkinson's and other neurological diseases has been cited by the larger scientific community over 10000 times [14]

Muqit is a member of the scientific advisory board of Mitokinin Inc. [15] He was formerly on the scientific advisory board of Amgen Inc.

His work was also covered widely on media including TV news, Scotland Tonight, where he was asked for his professional take on the subject. [16]

Awards

Related Research Articles

<span class="mw-page-title-main">Medical Research Council (United Kingdom)</span> National medical research agency

The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy.

Sir John Anthony Hardy is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.

Sir Philip Cohen is a British researcher, academic and Royal Medal winner based at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences at the University of Dundee.

<span class="mw-page-title-main">PINK1</span> Protein-coding gene in the species Homo sapiens

PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.

Frank S. Walsh PhD, DSc (Hon.) FMedSci, FKC, corrFRSE is a British-born neuroscientist. He is best known for his work on the understanding of the role of cell adhesion molecules in the development and regeneration of the nervous system. He is the author of over 250 publications in peer-reviewed journals.

Veronica van Heyningen is an English geneticist who specialises in the etiology of anophthalmia as an honorary professor at University College London (UCL). She previously served as head of medical genetics at the MRC Human Genetics Unit in Edinburgh and the president of The Genetics Society. In 2014 she became president of the Galton Institute. As of 2019 she chairs the diversity committee of the Royal Society, previously chaired by Uta Frith.

Dame Anna Felicja Dominiczak DBE FRCP FRSE FAHA FMedSci is a Polish-born British medical researcher, Regius Professor of Medicine - the first woman to hold this position, and the Chief Scientist (Health) for the Scottish Government. From 2010 to 2020, Dominiczak was the Vice-Principal and Head of the College of Medical, Veterinary and Life Sciences at the University of Glasgow, Scotland. She is an Honourary Consultant Physician and Endocrinologist for the NHS Greater Glasgow and Clyde Health Board, and Health Innovation Champion for the Medical Research Council. From 2013 to 2015, Dominiczak was president of the European Society of Hypertension. She is the current Editor-in-Chief of Precision Medicine, a new journal launched in July 2023.

Dario Renato Alessi is a French-born British biochemist, Director of the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and Professor of Signal Transduction, at the School of Life Sciences, University of Dundee.

<span class="mw-page-title-main">Stephen O'Rahilly</span> Irish-British physician and scientist

Sir Stephen Patrick O'Rahilly is an Irish-British physician and scientist known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders.

Michael G Hanna is Director of the UCL Institute of Neurology, University College London and professor in clinical neurology and consultant neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London, and also Director of the Medical Research Council (MRC) Centre for Neuromuscular Disease.

David Chaim Rubinsztein FRS FMedSci is the Deputy Director of the Cambridge Institute of Medical Research (CIMR), Professor of Molecular Neurogenetics at the University of Cambridge and a UK Dementia Research Institute Professor.

Sir Douglass Matthew Turnbull is Professor of Neurology at Newcastle University, an Honorary Consultant Neurologist at Newcastle upon Tyne Hospitals NHS Foundation Trust and a director of the Wellcome Trust Centre for Mitochondrial Research.

Joanna Marguerite Wardlaw is a Scottish physician, radiologist, and academic specialising in neuroradiology and pathophysiology. Wardlaw worked as a junior doctor before specialising as a radiologist. She continues to practice medicine as an Honorary Consultant Neuroradiologist with NHS Lothian. She has spent her entire academic career at the University of Edinburgh.

<span class="mw-page-title-main">Tracy Palmer</span> Professor of Molecular Microbiology

Tracy Palmer is a Professor of Microbiology in the Biosciences Institute at Newcastle University in Tyne & Wear, England. She is known for her work on the twin-arginine translocation (Tat) pathway.

<span class="mw-page-title-main">Charles Swanton</span>

(Robert) Charles Swanton is British physician scientist specialising in oncology and cancer research. Swanton is a senior group leader at London's Francis Crick Institute, Royal Society Napier Professor in Cancer and thoracic medical oncologist at University College London and University College London Hospitals, co-director of the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, and Chief Clinician of Cancer Research UK.

The School of Life Sciences at the University of Dundee conducts research into the molecular and cellular mechanisms underlying human health and disease.

<span class="mw-page-title-main">Helen Walden</span> English structural biologist

Helen Walden is an English structural biologist who received the Colworth medal from the Biochemical Society in 2015. She was awarded European Molecular Biology Organization (EMBO) membership in 2022. She is a Professor of Structural Biology at the University of Glasgow and has made significant contributions to the Ubiquitination field.

<span class="mw-page-title-main">Victoria Cowling</span> English biologist

Victoria Haigh Cowling FRSE is an English biologist who received the Women in Cell Biology Early Career Medal from the British Society for Cell Biology in 2014. Cowling is Professor of Biology, Lister Institute Fellow, MRC Senior Fellow and Deputy Head of The Centre for Gene Regulation and Expression at the University of Dundee.

Sonia Gandhi is a British physician and neuroscientist who leads the Francis Crick Institute neurodegeneration laboratory. She holds a joint position at the UCL Queen Square Institute of Neurology. Her research investigates the molecular mechanisms that give rise to Parkinson's disease. During the COVID-19 pandemic, Gandhi was involved with the epidemiological investigations and testing efforts at the Francis Crick Institute.

Professor Patrick Francis Chinnery, FRCP, FRCPath, FMedSci, is a neurologist, clinician scientist, and Wellcome Trust Principal Research Fellow based in the Medical Research Council Mitochondrial Biology Unit and the University of Cambridge, where he is also Professor of Neurology and Head of the Department of Clinical Neurosciences.

References

  1. 1 2 "Professor Miratul Muqit FRSE". The Royal Society of Edinburgh. 24 August 2020. Retrieved 27 August 2020.
  2. 1 2 3 4 5 MMuqit (2 September 2013). "Professor Miratul Muqit FRSE". School of Life Sciences. Retrieved 27 August 2020.
  3. 1 2 "Miratul Muqit". ppu.mrc.ac.uk. Retrieved 15 July 2020.
  4. ↑ "Edinburgh University". HeraldScotland. Retrieved 27 August 2020.
  5. ↑ "Kennedy Memorial Trust". www.kennedytrust.org.uk. Retrieved 27 August 2020.
  6. ↑ "Harvard BBS PhD Program". hms.harvard.edu. Retrieved 20 August 2020.
  7. 1 2 3 4 "Principal investigator". ppu.mrc.ac.uk. Retrieved 27 August 2020.
  8. 1 2 3 4 "Miratul Muqit". Linked In. Retrieved 15 July 2020.
  9. ↑ "World Parkinson's Day 2020 – Q&A with Professor Miratul Muqit". The Royal Society Blog. 11 April 2020. Retrieved 27 August 2020.
  10. 1 2 3 "Miratul Muqit, MD, PhD". The Michael J. Fox Foundation for Parkinson's Research | Parkinson's Disease. Retrieved 27 August 2020.
  11. ↑ amycameron (23 October 2018). "Professorships for Kim Dale and Miratul Muqit". School of Life Sciences. Retrieved 27 August 2020.
  12. ↑ "Scopus preview - Scopus - Author details (Muqit, Miratul M.K.)". www.scopus.com. Retrieved 27 August 2020.
  13. ↑ McWilliams, Thomas G; Muqit, Miratul MK (22 April 2017). "PINK1 and Parkin: emerging themes in mitochondrial homeostasis". Current Opinion in Cell Biology. 45: 83–91. doi: 10.1016/j.ceb.2017.03.013 . PMID   28437683.
  14. ↑ "Miratul Muqit - Google Scholar". scholar.google.co.uk. Retrieved 27 August 2020.
  15. ↑ "About Us". Mitokinin. Retrieved 27 August 2020.
  16. ↑ "Scotland tonight tweet". Twitter. Retrieved 27 August 2020.
  17. ↑ "Queen Square Alumnus Association Newsletter number 29" (PDF). 2007. Retrieved 27 August 2020.
  18. ↑ SHussain (13 December 2013). "Royal College of Physicians honour for Miratul Muqit". School of Life Sciences. Retrieved 27 August 2020.
  19. ↑ "Miratul Muqit elected Fellow of the Royal College of Physicians". ppu.mrc.ac.uk. Retrieved 27 August 2020.
  20. ↑ "Find an EMBO Young Investigator / EMBO Installation Grantee / EMBO Global Investigator". yip-search.embo.org. Retrieved 27 August 2020.
  21. ↑ Dundee, University of. "Dundee Clinician Scientist Receives Prestigious Medical Prize : News". University of Dundee. Retrieved 27 August 2020.
  22. ↑ "Francis Crick Medal and Lecture | Royal Society". royalsociety.org. Retrieved 27 August 2020.
  23. ↑ amycameron (15 January 2020). "Brian Cox Prize - Engaged Researcher". School of Life Sciences. Retrieved 27 August 2020.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.