Mithridatism is the practice of protecting oneself against a poison by gradually self-administering non-lethal amounts. The word is derived from Mithridates VI, the king of Pontus, who so feared being poisoned that he regularly ingested small doses, aiming to develop immunity.
Mithridates VI's father, Mithridates V, was assassinated by poisoning by a conspiracy among his attendants. [1] After this, Mithridates VI's mother held regency over Pontus (a Hellenistic kingdom, 281 BC–62 AD) until a male heir came of age. Mithridates was in competition with his brother for the throne and his mother began to favor his brother. [2] : 68 Supposedly, during his youth, he began to suspect plots against him at his own mother's orders and was aware of her possible connection with his father's death. He then began to notice pains in his stomach during his meals and suspected his mother had ordered small amounts of poison to be added to his food to slowly kill him off. With other assassination attempts, he fled into the wild. [2] : 69
While in the wild, it is said that he began ingesting non-lethal amounts of poisons and mixing many into a universal remedy to make him immune to all known poisons. [3]
After Mithridates' death, many Roman physicians claimed to possess and improve the formula. In keeping with most medical practices of his era, Mithridates' anti-poison routines included a religious component, supervised by the Agari, a group of Scythian shamans who never left him. [4]
It has been suggested that Russian mystic Rasputin's survival of a poisoning attempt was due to mithridatism, but this has not been proven. [5]
Indian epics talk about this practice as well. It has been said that, during the rule of the king Chandragupta Maurya (320–298 BC), there was a practice of selecting beautiful girls and administering poison in small amounts until they grew up, thus making them insensitive to poison. These maidens were called vishakanyas (visha 'poison' + kanya 'maiden'). It was believed that making love with vishakanyas could result in the death of their partners, hence they were employed to kill enemies.[ citation needed ]
The emperor Bindusara was the son of the first Mauryan emperor Chandragupta Maurya and his queen Durdhara. According to the Rajavalikatha, a Jain work, the original name of this emperor was Simhasena. A legend mentioned in the Jain texts tells the story of how Chandragupta's Guru and advisor Chanakya used to feed the emperor with small doses of poison to build his immunity against possible poisoning attempts by his enemies. [6] One day, Chandragupta, unaware that his food contained poison, shared his food with his pregnant wife, Queen Durdhara, who was seven days away from delivery. The queen, who was not immune to the poison, collapsed and died within a few minutes. Chanakya entered the room at the moment she collapsed, and in order to save the child in the womb, he immediately cut open the dead queen's belly and took the baby out. He was just in time; a drop of poison had already reached the baby and touched his head, leaving a permanent blueish spot (a "bindu") on his forehead. Thus, the newborn was named "Bindusara". [7]
Mithridatism is not effective against all types of poison. Immunity is generally only possible with biologically complex types which the immune system can respond to. Depending on the toxin, the practice can lead to the lethal accumulation of a poison in the body. Results depend on how each poison is processed by the body, i.e. on how the toxic compound is metabolized or passed out of the body. [8]
However, in some cases, it is possible to build up a metabolic tolerance against specific non-biological poisons. This involves conditioning the liver to produce more of the particular enzymes that metabolize these poisons. For example, heavy drinkers develop a tolerance to the effects of alcohol. [9] However, metabolic tolerance can also lead to accumulation of the less toxic metabolized compound which can slowly damage the liver. With alcohol this generally leads to conditions such as alcoholic fatty liver disease. [10]
Metabolic tolerance is not effective on all types of non-biological poisons. Exposure to certain toxic substances, such as hydrofluoric acid and heavy metals, is either lethal or has little to no effect. A minor exception is cyanide, which can be metabolized by the liver. The enzyme rhodanese converts the cyanide into the much less toxic thiocyanate. [11] This process allows humans to ingest small amounts of cyanide in food like apple seeds and survive small amounts of cyanide gas from fires and cigarettes. However, one cannot effectively condition the liver against cyanide, unlike alcohol. Relatively larger amounts of cyanide are still highly lethal because, while the body can produce more rhodanese, the process also requires large amounts of sulfur-containing substrates. [12]
Mithridatism has been used as a plot device in fiction and on-screen; including the Indian fantasy series Chandrakanta , Alexandre Dumas's The Count of Monte Cristo , Holly Black's "The Cruel Prince", Nathaniel Hawthorne's "Rappaccini's Daughter", Yoshiaki Kawajiri's Ninja Scroll , Dorothy Sayers's Strong Poison , Agatha Christie's Curtain , the manhwa Roxana, the manga/anime Spy x Family, the manga/anime/light novel series The Apothecary Diaries, William Goldman's The Princess Bride (as well as its film adaptation), and the American historical series The Borgias .
In Michael Curtis Ford's historical novel The Last King, on the life and conquests of Mithridates VI, the technique is used by Mithridates.
A. E. Housman's "Terence, this is stupid stuff" (originally published in A Shropshire Lad ) invokes mithridatism as a metaphor for the benefit that serious poetry brings to the reader. The final section is a poetic rendition of the Mithridates legend.
A poison is any chemical substance that is harmful or lethal to living organisms. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broad sense.
Acetonitrile, often abbreviated MeCN, is the chemical compound with the formula CH3CN and structure H3C−C≡N. This colourless liquid is the simplest organic nitrile. It is produced mainly as a byproduct of acrylonitrile manufacture. It is used as a polar aprotic solvent in organic synthesis and in the purification of butadiene. The N≡C−C skeleton is linear with a short C≡N distance of 1.16 Å.
Mithridates or Mithradates is the Hellenistic form of an Iranian theophoric name, meaning "given by Mithra". Its Modern Persian form is Mehrdad. It may refer to:
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). Sometimes the word is more or less synonymous with poisoning in everyday usage.
Iron poisoning typically occurs from ingestion of excess iron that results in acute toxicity. Mild symptoms which occur within hours include vomiting, diarrhea, abdominal pain, and drowsiness. In more severe cases, symptoms can include tachypnea, low blood pressure, seizures, or coma. If left untreated, acute iron poisoning can lead to multi-organ failure resulting in permanent organ damage or death.
Hormesis is a two-phased dose-response relationship to an environmental agent whereby low-dose amounts have a beneficial effect and high-dose amounts are either inhibitory to function or toxic. Within the hormetic zone, the biological response to low-dose amounts of some stressors is generally favorable. An example is the breathing of oxygen, which is required in low amounts via respiration in living animals, but can be toxic in high amounts, even in a managed clinical setting.
Bindusara was the second Mauryan emperor of Magadha in Ancient India. The ancient Greco-Roman writers called him Amitrochates, a name likely derived from his Sanskrit title Amitraghāta.
Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produced by the fungus.
T-2 mycotoxin is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and other animals. The clinical condition it causes is alimentary toxic aleukia and a host of symptoms related to organs as diverse as the skin, airway, and stomach. Ingestion may come from consumption of moldy whole grains. T-2 can be absorbed through human skin. Although no significant systemic effects are expected after dermal contact in normal agricultural or residential environments, local skin effects can not be excluded. Hence, skin contact with T-2 should be limited.
Mithridate, also known as mithridatium, mithridatum, or mithridaticum, is a semi-mythical remedy with as many as 65 ingredients, used as an antidote for poisoning, and said to have been created by Mithridates VI Eupator of Pontus in the 1st century BC. It was one of the most complex and highly sought-after drugs during the Middle Ages and the Renaissance, particularly in Italy and France, where it was in continual use for centuries. An updated recipe called theriac was known well into the 19th century.
Cyanide poisoning is poisoning that results from exposure to any of a number of forms of cyanide. Early symptoms include headache, dizziness, fast heart rate, shortness of breath, and vomiting. This phase may then be followed by seizures, slow heart rate, low blood pressure, loss of consciousness, and cardiac arrest. Onset of symptoms usually occurs within a few minutes. Some survivors have long-term neurological problems.
The history of poison stretches from before 4500 BCE to the present day. Poisons have been used for many purposes across the span of human existence, most commonly as weapons, anti-venoms, and medicines. Poison has been heavily studied in toxicology, among other sciences, and its use has led to several technological innovations.
Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include intoxication, vomiting and abdominal pain. Later symptoms may include a decreased level of consciousness, headache, and seizures. Long term outcomes may include kidney failure and brain damage. Toxicity and death may occur after drinking even in a small amount as ethylene glycol is more toxic than other diols.
Mithridates or Mithradates VI Eupator was the ruler of the Kingdom of Pontus in northern Anatolia from 120 to 63 BC, and one of the Roman Republic's most formidable and determined opponents. He was an effective, ambitious and ruthless ruler who sought to dominate Asia Minor and the Black Sea region, waging several hard-fought but ultimately unsuccessful wars to break Roman dominion over Asia and the Hellenic world. He has been called the greatest ruler of the Kingdom of Pontus. He cultivated an immunity to poisons by regularly ingesting sub-lethal doses; this practice, now called mithridatism, is named after him. After his death, he became known as Mithridates the Great.
α-Naphthylthiourea (ANTU) is an organosulfur compound with the formula C10H7NHC(S)NH2. This a white, crystalline powder although commercial samples may be off-white. It is used as a rodenticide and as such is fairly toxic. Naphthylthiourea is available as 10% active baits in suitable protein- or carbohydrate-rich materials and as a 20% tracking powder.
Tutin is a poisonous plant derivative found in New Zealand tutu plants. It acts as a potent antagonist of the glycine receptor, and has powerful convulsant effects. It is used in scientific research into the glycine receptor. It is sometimes associated with outbreaks of toxic honey poisoning when bees feed on honeydew exudate from the sap-sucking passion vine hopper insect, when the vine hoppers have been feeding on the sap of tutu bushes. Toxic honey is a rare event and is more likely to occur when comb honey is eaten directly from a hive that has been harvesting honeydew from passionvine hoppers feeding on tutu plants.
Senecionine is a toxic pyrrolizidine alkaloid isolated from various botanical sources. It takes its name from the Senecio genus and is produced by many different plants in that genus, including Jacobaea vulgaris. It has also been isolated from several other plants, including Brachyglottis repanda, Emilia, Erechtites hieraciifolius, Petasites, Syneilesis, Crotalaria, Caltha leptosepala, and Castilleja.
Methacrylonitrile, MeAN in short, is a chemical compound that is an unsaturated aliphatic nitrile, widely used in the preparation of homopolymers, copolymers, elastomers, and plastics and as a chemical intermediate in the preparation of acids, amides, amines, esters, and other nitriles. MeAN is also used as a replacement for acrylonitrile in the manufacture of an acrylonitrile/butadiene/styrene-like polymer. It is a clear and colorless liquid, that has a bitter almond smell.
Methanol toxicity is poisoning from methanol, characteristically via ingestion. Symptoms may include a decreased level of consciousness, poor or no coordination, vomiting, abdominal pain, and a specific smell on the breath. Decreased vision may start as early as twelve hours after exposure. Long-term outcomes may include blindness and kidney failure. Blindness may occur after drinking as little as 10 mL; death may occur after drinking quantities over 15 mL.
Poisoning is the harmful effect which occurs when toxic substances are introduced into the body. The term "poisoning" is a derivative of poison, a term describing any chemical substance that may harm or kill a living organism upon ingestion. Poisoning can be brought on by swallowing, inhaling, injecting or absorbing toxins through the skin. Toxicology is the practice and study of symptoms, mechanisms, diagnoses, and treatments correlated to poisoning.
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