Mitosene

Not to be confused with mitosan.

Chemical structure of mitosene

The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins. ^{[1] [2]}

References

1. Maliepaard, Marc; de Mol, Nico J.; Tomasz, Maria; Gargiulo, Dario; Janssen, Lambert H. M.; van Duynhoven, John P. M.; van Velzen, Ewoud J. J.; Verboom, Willem; Reinhoudt, David N. (1997). "Mitosene–DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon Reductive Activation" . Biochemistry. 36 (30): 9211–9220. doi:10.1021/bi9700680. PMID   9230054.
2. Iyengar, 1 Bhashyam S.; Remers, William A. (1985). "A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes". J. Med. Chem. 28 (7): 963–967. doi:10.1021/jm00145a021. PMID   3925148.