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Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, 18
F
-FDG is commonly used to detect cancer, NaF18
F
is widely used for detecting bone formation, and oxygen-15 is sometimes used to measure blood flow.
Single-photon emission computed tomography is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera, but is able to provide true 3D information. This information is typically presented as cross-sectional slices through the patient, but can be freely reformatted or manipulated as required.
A radioligand is a radioactive biochemical substance, in particular, a ligand that is radiolabeled. Radioligands are used for diagnosis or for research-oriented study of the receptor systems of the body, and for anti-cancer radioligand therapy.
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Professor Rajendra D Badgaiyan is an Indian-American psychiatrist and cognitive neuroscientist. He is best known for developing a new neuroimaging technique for detection of acute changes in concentration of dopamine released in the live human brain during performance of a cognitive. behavioral or emotional task.
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Julie A. Fiez is a cognitive neuroscientist known for her research on the neural basis of speech, language, reading, working memory, and learning in healthy and patient populations. She is Professor of Psychology and Neuroscience at the Learning Research and Development Center and the Center for the Neural Basis of Cognition at the University of Pittsburgh. She is also Adjunct Faculty in the Department of Psychology at Carnegie Mellon University.
Julie C. Price is an American medical physicist and professor of radiology at Massachusetts General Hospital (MGH), Harvard Medical School (HMS), as well as the director of PET Pharmacokinetic Modeling at the Athinoula A. Martinos Center at MGH. Price is a leader in the study and application of quantitative positron emission tomography (PET) methods. Prior to this, Price worked with Pittsburgh colleagues to lead the first fully quantitative pharmacokinetic evaluations of 11C-labeled Pittsburgh compound-B (PIB), one of the most widely used PET ligands for imaging amyloid beta plaques. As a principal investigator at MGH, Price continues work to validate novel PET methods for imaging biological markers of health and disease in studies of aging and neurodegeneration, including studies of glucose metabolism, protein expression, neurotransmitter system function, and tau and amyloid beta plaque burden.
References
- ↑ "UCSD Profiles: Monte Buchsbaum". UCSD . Retrieved 2018-02-12.
He heads the new NeuroPET Center and leads an effort in developing an expanded research effort with positron emission tomography.
- ↑ "M.S. Buchsbaum: Editor-in-Chief, Psychiatry Research". Psychiatry Research . Retrieved 2018-02-12.
- ↑ Buchsbaum, Monte S. (1982). "Cerebral Glucography With Positron Tomography". Archives of General Psychiatry. 39 (3): 251–9. doi:10.1001/archpsyc.1982.04290030001001. ISSN 0003-990X. PMID 6978119.
- ↑ Kevin Davis (2017). The Brain Defense: Murder in Manhattan and the Dawn of Neuroscience in America's Courtrooms. Penguin books. ISBN 9780698183353 . Retrieved 2018-02-12.
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