Mosaad Megahed

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Mosaad Megahed
Born (1956-12-10) December 10, 1956 (age 66)
NationalityEgyptian
Known forgeneral dermatology, dermatopathology, autoimmune and hereditary blistering diseases
AwardsK.G. Steigleder-Prize
Scientific career
Fieldsskin and genital diseases as well as dermatohistology
Institutions University Hospital Aachen

Mosaad Megahed (born December 10, 1956 in Alexandria, Egypt) is an Egyptian specialist in skin and genital diseases as well as dermatohistology. He is professor and senior physician at the Clinic for Dermatology and Allergology of the University Hospital Aachen. His main focus areas are general dermatology, dermatopathology, autoimmune and hereditary blistering diseases, skin cancer as well as immunological inflammatory skin diseases like atopic dermatitis, collagen diseases, vitiligo and urticaria.

Contents

Biography

After Megahed had finished his studies in medicine, he was a resident in the department of Dermatology and Allergology at the University Hospital of the University of Düsseldorf with Gerd Plewig. In 1990 he was recognized as a specialist in skin and genital diseases and one year later he received the additional title allergology. In 1991 Megahed went to the University of Glasgow to join the research team of Rona MacKie. He returned to the University Dermatologic Hospital Düsseldorf as senior physician in the same year. In 1994 he achieved his doctorate in medicine. From 1994 until 1996 Megahed had been completing a research stay at the Thomas Jefferson University in Philadelphia with Jouni Uitto. During that time, he also continued his training in dermatohistology with Bernie Ackerman at the same university. In 1996 he habilitated and received the teaching license at the University of Düsseldorf, where he has been working as professor and senior physician until 2005. In 2005 Megahed changed to the University RWTH Aachen, where he has been professor and senior physician until today. [1] Since 2006, Megahed has the additional title Dermahistology. He also is working as an examiner at the Medical Association North Rhine-Westphalia. [2]

Scientific contribution

Awards

In 2003 Megahed and his colleagues received the K.G. Steigleder-Price for the best work on dermahistology by the working group Dermatological Histology (ADH). [15]

Memberships in scientific organizations

Megahed is a member of the German Dermatological Society, German Research Foundation and German Working Group for Dermatohistology, and the European Society of Dermatopathology. [16]

Publications

Books

Articles

Megahed published more than 280 articles in scientific journals (April 2016).

Related Research Articles

<span class="mw-page-title-main">Pathology</span> Study of the causes and effects of disease or injury, and how they arise

Pathology is the study of the causes and effects of disease or injury. The word pathology also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue and human cell samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases, and the affix pathy is sometimes used to indicate a state of disease in cases of both physical ailment and psychological conditions. A physician practicing pathology is called a pathologist.

<span class="mw-page-title-main">Melanocytic nevus</span> Medical condition

A melanocytic nevus is usually a noncancerous condition of pigment-producing skin cells. It is a type of melanocytic tumor that contains nevus cells. Some sources equate the term mole with "melanocytic nevus", but there are also sources that equate the term mole with any nevus form.

Dermatology is the branch of medicine dealing with the skin. It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical doctor who manages diseases related to skin, hair, nails, and some cosmetic problems.

<span class="mw-page-title-main">Chilblains</span> Medical condition

Chilblains, also known as pernio, is a medical condition in which damage occurs to capillary beds in the skin, most often in the hands or feet, when blood perfuses into the nearby tissue, resulting in redness, itching, inflammation, and possibly blisters. It occurs most frequently when predisposed individuals, predominantly women, are exposed to cold and humidity. Ulcerated chilblains are referred to as kibes. Temperature-related chilblains can be prevented by keeping the feet and hands warm in cold weather and avoiding exposing these areas to extreme temperature changes. Once the diagnosis of chilblains is made, first-line treatment includes avoiding cold, damp environments and wearing gloves and warm socks.

<span class="mw-page-title-main">Skin condition</span> Any medical condition that affects the integumentary system

A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment.

<span class="mw-page-title-main">Dermatoscopy</span> Medical examination of the skin

Dermatoscopy also known as dermoscopy or epiluminescence microscopy, is the examination of skin lesions with a dermatoscope. It is a tool similar to a camera to allow for inspection of skin lesions unobstructed by skin surface reflections. The dermatoscope consists of a magnifier, a light source, a transparent plate and sometimes a liquid medium between the instrument and the skin. Dermatoscope is often handheld, although there are stationary cameras allowing the capture of whole body images in a single shot. When the images or video clips are digitally captured or processed, the instrument can be referred to as a digital epiluminescence dermatoscope. The image is then analyzed automatically and given a score indicating how dangerous it is. This technique is useful to dermatologists and skin cancer practitioners in distinguishing benign from malignant (cancerous) lesions, especially in the diagnosis of melanoma.

<span class="mw-page-title-main">Josef Jadassohn</span> German dermatologist

Joseph (Josef) Jadassohn was a German dermatologist.

Hans Christian Korting was a German dermatologist and medical researcher specializing in causes and treatment of infectious and non-infectious inflammatory skin diseases as well as non-melanoma skin cancer".

<span class="mw-page-title-main">Dermatitis herpetiformis</span> Medical condition

Dermatitis herpetiformis (DH) is a chronic autoimmune blistering skin condition, characterised by intensely itchy blisters filled with a watery fluid. DH is a cutaneous manifestation of coeliac disease, although the exact causal mechanism is not known. DH is neither related to nor caused by herpes virus; the name means that it is a skin inflammation having an appearance similar to herpes.

<span class="mw-page-title-main">Ichthyosis bullosa of Siemens</span> Medical condition

Ichthyosis bullosa of Siemens is a type of familial, autosomal dominant ichthyosis, a rare skin disorder. It is also known as bullous congenital ichthyosiform erythroderma of Siemens or ichthyosis exfoliativa. It is a genetic disorder with no known cure which is estimated to affect about 1 in 500,000 people.

Albert Bernard Ackerman, M.D. was an American dermatologist and pathologist who was "a founding figure in the field of dermatopathology."

<span class="mw-page-title-main">Sunburn</span> Burning of the skin by the suns radiation

Sunburn is a form of radiation burn that affects living tissue, such as skin, that results from an overexposure to ultraviolet (UV) radiation, usually from the sun. Common symptoms in humans and other animals include: red or reddish skin that is hot to the touch or painful, general fatigue, and mild dizziness. Other symptoms include blistering, peeling skin, swelling, itching, and nausea. Excessive UV radiation is the leading cause of (primarily) non-malignant skin tumors, which in extreme cases can be life-threatening. Sunburn is an inflammatory response in the tissue triggered by direct DNA damage by UV radiation. When the cells' DNA is overly damaged by UV radiation, type I cell-death is triggered and the tissue is replaced.

Pseudomelanoma is a cutaneous condition in which melanotic skin lesions clinically resemble a superficial spreading melanoma at the site of a recent shave removal of a melanocytic nevus.

Walter Russell "Nick" Nickel, M.D. was an American dermatologist who was one of the founders of the field of dermatopathology. He was a co-founder and president of four different professional societies and was the founding chairman of the Division of Dermatology at the University of California, San Diego Medical Center.

<span class="mw-page-title-main">Alexander Kapp (dermatologist and allergist)</span> German dermatologist and medical professor (born 1955)

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Clay J. Cockerell is an American physician who works in the field of dermatology and dermatopathology. He is the founder and medical director of Cockerell Dermatopathology, a medical laboratory he operates in Dallas, Texas. He is also a clinical professor of dermatology and dermatopathology at the University of Texas Southwestern Medical Center where he also serves as the director of the dermatopathology division.

Lajos Kemény is a Hungarian dermatologist, venereologist, allergologist, medical researcher, full professor and the Head of the Department of Dermatology and Allergology, the director of the Albert Szent-Györgyi Health Center, Faculty of Medicine, University of Szeged and the Vice-Rector for Science, Research Development and Innovation. He is a notable and respected scientist both in Hungary and around the world.

Thomas Tüting is a German dermatologist and researcher at Otto von Guericke University Magdeburg. He is the clinical director of dermatology and the head of the Laboratory of Experimental Dermatology. His research interests include the identification and characterization of factors responsible for cancer progression and metastasis and resistance to cancer immunotherapy.

Günter Burg is a German dermatologist. Born in Mayen, Germany, he holds German and Swiss citizenship. He has been married to Dr. Doris Burg-Nicklas, a neurologist, since 1968. They have two sons: Andreas and Thomas.

<span class="mw-page-title-main">Stephen I. Katz</span> American physician

Stephen Ira Katz was an American immunodermatologist who served as the director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases from 1995 to 2018. He was the Marion B. Sulzberger Professor of Dermatology at the Uniformed Services University of the Health Sciences from 1989 to 1995.

References

  1. University Hospital Aachen, functional areas
  2. "CV of Mosaad Megahed (German)". Archived from the original on 2016-03-04. Retrieved 2016-05-15.
  3. MyBioSource Ladinin
  4. U42408 GenBank
  5. O00515 NCBI
  6. U58994 GenBank Archived 2016-04-25 at archive.today
  7. U58011 GenBank Archived 2016-04-25 at archive.today
  8. M. Megahed, M. Schon, D. Selimovic, M. P. Schön: Reliability of diagnosis of melanoma in situ. In: Lancet. 359, 2002, S. 1921–1922.
  9. M. Megahed: Histopathology of Blistering Diseases - With Clinical, Electron Microscopic, Immunological and Molecular Biological Correlations Textbook and Atlas. Springer Verlag, Berlin/ Heidelberg 2004, ISBN   3-540-42562-4.
  10. C. Schuetz, K. Huck, S. Gudowius, M. Megahed, O. Feyen, B. Hubner, D. T. Schneider, B. Manfras, U. Pannicke, R. Willemze, R. Knüchel, U. Göbel, A. Schulz, A. Borkhardt, W. Friedrich, K. Schwarz, T. Niehues: An Immunodeficiency Disease with RAG Mutations and Granulomas. In: New England Journal of Medicine. 358, 2008, S. 2030–2038.
  11. B. Voss, S. Wilop, S. Jonas, M. H. M. El-Komy, J. Schaller, V. von Felbert, M. Megahed: Tumor Volume as a Prognostic Factor in Resectable Malignant Melanoma. In: Dermatology. 228, 2014, S. 66–70.
  12. A. El-Khattouti, D. Selimovic, M. Hannig, E. B. Taylor, Z. Y. Abd-Elmageed, S. Y. Hassan, Y. Haikel, E. Kandil, M. Leverkus, R. T. Brodell, M. Megahed, M. Hassan: Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition. In: J Cell Mol Med. 20, 2016, S. 266–286.
  13. M. Hassan, D. Selimovic, M. Hannig, Y. Haikel, R. T. Brodell, M. Megahed: Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment. In: World J Exp Med. 5(4), 20. Nov 2015, S. 206–217.
  14. A. El-Khattouti, N. Sheehan, J. Monico, H. A. Drummond, Y. Haikel, R. T. Brodell, M. Megahed, M. Hassan: CD133+ melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: Significance for melanoma treatment. In: . Cancer Lett. 357, 2015, S. 83–104.
  15. K.G. Steigleder-Price for M. Megahed Archived 2016-04-29 at the Wayback Machine
  16. European Society of Dermatopathology