Mustard Database

Mustard

Content
Description	Contains AR determinants and curated AR genes identified from metagenomics
Data types captured	Antimicrobial resistance genes and AR Determinants
Organisms	Bacteria
Contact
Primary citation	PMID   30478291
Access
Website	mgps.eu/Mustard/
Download URL	Download
Miscellaneous
Bookmarkable entities	yes

Mustard is a database that tracks Antimicrobial Resistance Determinants (ARDs). The method by which it tracks ARDs is using their own method adapted from Protein Homology Modelling called Pairwise Comparative Modelling (PCM), which increase specificity protein prediction, especially for distantly related protein homologues. ^[1] Using PCM, 6095 ARDs from 20 families in the human gut microbiota. Antibiotic resistance databases used were ResFinder, ^[2] ARG-ANNOT, ^[3] the now defunct Lahey Clinic, ^[4] Marilyn Roberts website for tetracycline and macrolide resistance genes ^[5] and metagenomics. ^{[6] [7] [8]}

See also

• Antimicrobial Resistance databases

References

1. Ehrlich, S. Dusko; Kennedy, Sean P.; Doré, Joël; Haimet, Florence; Weiszer, Kevin; Levenez, Florence; Letur, Aline; Léjard, Véronique; Léonard, Pierre (January 2019). "Prediction of the intestinal resistome by a three-dimensional structure-based method" (PDF). Nature Microbiology. 4 (1): 112–123. doi: 10.1038/s41564-018-0292-6 . ISSN   2058-5276. PMID   30478291. S2CID   53757858.
2. Zankari, E.; Hasman, H.; Cosentino, S.; Vestergaard, M.; Rasmussen, S.; Lund, O.; Aarestrup, F. M.; Larsen, M. V. (2012-07-10). "Identification of acquired antimicrobial resistance genes". Journal of Antimicrobial Chemotherapy. 67 (11): 2640–2644. doi:10.1093/jac/dks261. ISSN   0305-7453. PMC   3468078 . PMID   22782487.
3. Gupta, Sushim Kumar; Padmanabhan, Babu Roshan; Diene, Seydina M.; Lopez-Rojas, Rafael; Kempf, Marie; Landraud, Luce; Rolain, Jean-Marc (2013-10-21). "ARG-ANNOT, a New Bioinformatic Tool To Discover Antibiotic Resistance Genes in Bacterial Genomes". Antimicrobial Agents and Chemotherapy. 58 (1): 212–220. doi:10.1128/aac.01310-13. ISSN   0066-4804. PMC   3910750 . PMID   24145532.
4. "RED-DB" . Retrieved July 27, 2019.
5. "Marilyn Roberts website".
6. Allen, Heather K; Moe, Luke A; Rodbumrer, Jitsupang; Gaarder, Andra; Handelsman, Jo (2008-10-09). "Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil". The ISME Journal. 3 (2): 243–251. doi: 10.1038/ismej.2008.86 . ISSN   1751-7362. PMID   18843302. S2CID   16496336.
7. Moore, Aimée M.; Patel, Sanket; Forsberg, Kevin J.; Wang, Bin; Bentley, Gayle; Razia, Yasmin; Qin, Xuan; Tarr, Phillip I.; Dantas, Gautam (2013-11-13). "Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance Genes". PLOS ONE. 8 (11) e78822. Bibcode:2013PLoSO...878822M. doi: 10.1371/journal.pone.0078822 . ISSN   1932-6203. PMC   3827270 . PMID   24236055.
8. Sommer, M. O. A.; Dantas, G.; Church, G. M. (2009-08-27). "Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora". Science. 325 (5944): 1128–1131. Bibcode:2009Sci...325.1128S. doi:10.1126/science.1176950. ISSN   0036-8075. PMC   4720503 . PMID   19713526.