Nabil F. Saba

Last updated
Nabil F. Saba
Saba Nabil.jpg
Alma mater
Awards
  • Received Distinguished Doctor (2015) [1]
Scientific career
Institutions Emory University
Website

Nabil F. Saba is an American oncologist. He is currently Professor and Vice-chair of Hematology and Medical Oncology, and Professor of Otolaryngology at the Winship Cancer Institute at the Emory University School of Medicine in Atlanta, Georgia. [2] He is a specialist in the field of head and neck oncology. Saba has authored more than 200 peer-reviewed articles. [3] He is the inaugural Lynne and Howard Halpern Chair in Head and Neck Cancer Research. [4]

Contents

Saba is an elected member of the American Head and Neck Society (AHNS) [3] and also specializes in immunotherapy for head and neck cancer, and T cell and B cell activation related to HPV-positive disease. [5] [6]

Saba’s work focused on translational research and the study and development of novel therapeutic agents and modalities in the head, neck, and esophageal cancer. He led several clinical trials and chaired national and investigator-initiated multi-institution studies focused on novel approaches for treating these diseases. He is also the editor of two published textbooks, Sinonasal and Skull Base Malignancies and Esophageal Cancer, prevention, diagnosis, and therapy. [3]

Research and career

Nabil Saba earned a B.S. in chemistry at the American University of Beirut in Lebanon, completed his medical degree from the American University of Beirut Medical School. [4]

Saba’s research focused on targeting the epithelial growth factor receptor and related pathways in head and neck cancer and immunotherapy approaches for this disease. He investigated the role of related receptors such as HER3 and the mTOR pathway in treating advanced head and neck cancers. He also researched the role of chemoprevention in head and neck cancers. Saba is a national leader in cooperative group trials and chairs two NCTN studies within the ECOG-ACRIN cooperative group, EA3161 and EA3163.[6]

Among Saba’s research is the examination of the role of targeting H-Ras in combination with EGFR inhibition in non-HRas mutated head and neck squamous cell cancers. [7] [8]

Saba researched the relationship between radiation dose and overall survival in cervical esophageal cancer. [9] [10] He also conducted research on the peritumoral vasculature in head and neck cancer, revealing that patients with metastatic disease were more likely to have high peritumoral blood microvessel density (MVD). [11]

Saba has been the director of house staff education program at the Winship Cancer Institute of Emory University. [12] He co-directed the head and neck cancers multi-disciplinary program and directed the Head and Neck Medical Oncology Program. [13] [14]

Saba was an assistant professor in the Department of Hematology and Oncology, and served as the director of house staff education programs at the Winship Cancer Institute of Emory University. [12] During his tenure at Emory University School of Medicine, he has served in different positions including Hematology and Medical oncology Professor, Otolaryngology Professor, also lending his services at the Winship Cancer Institute of Emory University as the director of the Head and Neck Medical Oncology Program. [13] [14]

Memberships and awards

Saba won numerous awards including: [15] [16] [17]

Saba is a member of numerous professional organizations including the American College of Radiology, American College of Physicians, American Society of Clinical Oncology, and Massachusetts Medical Society. [18]

Publications

Related Research Articles

<span class="mw-page-title-main">Esophageal cancer</span> Gastrointestinal system cancer that is located in the esophagus

Esophageal cancer is cancer arising from the esophagus—the food pipe that runs between the throat and the stomach. Symptoms often include difficulty in swallowing and weight loss. Other symptoms may include pain when swallowing, a hoarse voice, enlarged lymph nodes ("glands") around the collarbone, a dry cough, and possibly coughing up or vomiting blood.

<span class="mw-page-title-main">Cutaneous squamous-cell carcinoma</span> Medical condition

Cutaneous squamous-cell carcinoma (cSCC), or squamous-cell carcinoma of the skin, also known as squamous-cell skin cancer, is, with basal-cell carcinoma and melanoma, one of the three principal types of skin cancer. cSCC typically presents as a hard lump with a scaly top layer, but it may instead form an ulcer. Onset often occurs over a period of months. Cutaneous squamous-cell carcinoma is more likely to spread to distant areas than basal cell cancer. When confined to the outermost layer of the skin, a pre-invasive, or in situ, form of cSCC is known as Bowen's disease.

<span class="mw-page-title-main">Oral cancer</span> Cancer of the lining of the lips, mouth, or upper throat

Oral cancer, also known as mouth cancer, is a cancer of the lining of the lips, mouth, or upper throat. In the mouth, it most commonly starts as a painless white patch, that thickens, develops red patches, an ulcer, and continues to grow. When on the lips, it commonly looks like a persistent crusting ulcer that does not heal, and slowly grows. Other symptoms may include difficult or painful swallowing, new lumps or bumps in the neck, a swelling in the mouth, or a feeling of numbness in the mouth or lips.

<span class="mw-page-title-main">Head and neck cancer</span> Cancer arises in the head or neck region

Head and neck cancer develops from tissues in the lip and oral cavity (mouth), larynx (throat), salivary glands, nose, sinuses, or skin of the face. The most common types of head and neck cancer occur in the lips, mouth, and larynx. Symptoms predominantly include a sore that does not heal or a change in the voice. In those with advanced disease, there may be unusual bleeding, facial pain, numbness or swelling, and visible lumps on the outside of the neck or oral cavity. Given the location of these cancers, it is possible for an afflicted individual to experience difficulty in breathing.

<span class="mw-page-title-main">Nasopharyngeal carcinoma</span> Type of throat cancer; most common to occur in the nasopharynx

Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess, accounting for 50% of cases. NPC occurs in children and adults. NPC differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. It is vastly more common in certain regions of East Asia and Africa than elsewhere, with viral, dietary and genetic factors implicated in its causation. It is most common in males. It is a squamous cell carcinoma of an undifferentiated type. Squamous epithelial cells are a flat type of cell found in the skin and the membranes that line some body cavities. Undifferentiated cells are cells that do not have their mature features or functions.

<span class="mw-page-title-main">Cyclin D1</span> Protein found in humans

Cyclin D1 is a protein that in humans is encoded by the CCND1 gene.

<span class="mw-page-title-main">Peroxiredoxin 1</span> Protein found in humans

Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.

<span class="mw-page-title-main">40S ribosomal protein S27</span> Protein found in humans

40S ribosomal protein S27 also known as metallopan-stimulin 1 or MPS-1 is a protein that in humans is encoded by the RPS27 gene. Metallopanstimulin is a zinc finger protein proposed to be involved DNA repair as well as oncogenesis.

<span class="mw-page-title-main">ING4</span> Protein-coding gene in the species Homo sapiens

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.

Eric M. Genden, MD, MHCA, FACS is a United States head and neck cancer surgeon at the Icahn School of Medicine at Mount Sinai and Mount Sinai Health System in New York City. where he serves as the Isidore Friesner Professor and Chairman of Otolaryngology–Head and Neck Surgery and Professor of Neurosurgery and Immunology. According to his biography at Mount Sinai, Genden's professional titles also include Senior Associate Dean for Clinical Affairs, He is Executive Vice President of Ambulatory Surgery, and Director of the Head and Neck Institute at the Mount Sinai Health System.

<span class="mw-page-title-main">Temoporfin</span> Chemical compound

Temoporfin (INN) is a photosensitizer used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck . It is marketed in the European Union under the brand name Foscan. The U.S. Food and Drug Administration (FDA) declined to approve Foscan in 2000. The EU approved its use in June 2001.

<span class="mw-page-title-main">HPV-positive oropharyngeal cancer</span> Cancer of the throat

Human papillomavirus-positive oropharyngeal cancer, is a cancer of the throat caused by the human papillomavirus type 16 virus (HPV16). In the past, cancer of the oropharynx (throat) was associated with the use of alcohol or tobacco or both, but the majority of cases are now associated with the HPV virus, acquired by having oral contact with the genitals of a person who has a genital HPV infection. Risk factors include having a large number of sexual partners, a history of oral-genital sex or anal–oral sex, having a female partner with a history of either an abnormal Pap smear or cervical dysplasia, having chronic periodontitis, and, among men, younger age at first intercourse and a history of genital warts. HPV-positive OPC is considered a separate disease from HPV-negative oropharyngeal cancer.

mir-205 Micro RNA involved in the regulation of multiple genes

In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes.

<span class="mw-page-title-main">Wolfram Samlowski</span> Oncologist

Wolfram Samlowski is an American medical oncologist with Comprehensive Cancer Centers of Nevada (CCCN) and a member of the Research Developmental Therapeutics and Genitourinary Committees for US Oncology. His research interests include translational research and development of novel cancer immunotherapy agents, translational drug development as well as gene therapy. His clinical interests are in developing more effective treatments for advanced stages of melanoma and non-melanoma skin cancers, and renal cancer.

In molecular biology mir-497 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene. It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye.

Sandro Porceddu is a head and neck radiation oncologist at Brisbane's Princess Alexandra Hospital and a Professor with the University of Queensland. He was president of the Clinical Oncologic Society of Australia (COSA) and chair of the Trials Scientific Committee of the Trans Tasman Radiation Oncology Group (TROG).

<span class="mw-page-title-main">Motolimod</span> Chemical compound

Motolimod (VTX-2337) is a drug which acts as a potent and selective agonist of toll-like receptor 8 (TLR8), a receptor involved in the regulation of the immune system. It is used to stimulate the immune system, and has potential application as an adjuvant therapy in cancer chemotherapy, although clinical trials have shown only modest benefits. It also worsens neuropathic pain in animal models and has been used to research the potential of targeting TLR8 in some kinds of chronic pain syndromes.

<span class="mw-page-title-main">Squamous-cell carcinoma</span> Carcinoma that derives from squamous epithelial cells

Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts.

Roy S. Herbst is an American oncologist who is the Ensign Professor of Medicine, Professor of Pharmacology, Chief of Medical Oncology, and Associate Director for Translational Research at Yale Cancer Center and Yale School of Medicine in New Haven, Connecticut.

References

  1. ↑ "Naba Sabil". emory.edu.
  2. ↑ "Profile | Emory School of Medicine". med.emory.edu. Retrieved 2019-10-23.
  3. 1 2 3 "Nabil Saba - Google Scholar Citations". scholar.google.com. Retrieved 2019-10-23.
  4. 1 2 "emory.edu". whsc.emory.edu. Retrieved 2019-10-23.
  5. ↑ Wieland A, Patel MR, Cardenas MA, Eberhardt CS, Hudson WH, Obeng RC, Griffith CC, Wang X, Chen ZG, Kissick HT, Saba NF, Ahmed R (September 2021). "Defining HPV-specific B cell responses in patients with head and neck cancer". Nature. 597 (7875): 274–278. doi:10.1038/s41586-020-2931-3. PMC   9462833 . PMID   33208941.
  6. ↑ Eberhardt CS, Kissick HT, Patel MR, Cardenas MA, Prokhnevska N, Obeng RC, Nasti TH, Griffith CC, Im SJ, Wang X, Shin DM, Carrington M, Chen ZG, Sidney J, Sette A, Saba NF, Wieland A, Ahmed R (September 2021). "Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer". Nature. 597 (7875): 279–284. Bibcode:2021Natur.597..279E. doi:10.1038/s41586-021-03862-z. PMC   10201342 . PMID   34471285. S2CID   237387748.
  7. ↑ Shu L, Wang D, Nannapaneni S, Sun Y, Griffith CC, Wang X, Chen Z, Patel M, El-Deiry M, Shin DM, Chen ZG, Saba NF (November 2021). "Tipifarnib enhances anti-EGFR activity of cetuximab in non-HRas mutated head and neck squamous cell carcinoma cancer (HNSCC)". Oral Oncol. 122: 105546. doi:10.1016/j.oraloncology.2021.105546. PMID   34700281. S2CID   239983649.
  8. ↑ Saba NF, Dinasarapu AR, Magliocca KR, Dwivedi B, Seby S, Qin ZS, Patel M, Griffith CC, Wang X, El-Deiry M, Steuer CE, Kowalski J, Shin DM, Zwick ME, Chen ZG (2020). "Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC)". PLOS ONE. 15 (9): e0238497. Bibcode:2020PLoSO..1538497S. doi: 10.1371/journal.pone.0238497 . PMC   7521680 . PMID   32986729.
  9. ↑ Saba, N.; Sutton, D. M.; Ross, H. J.; Siu, S.; Crump, R. M.; Keating, A.; Stewart, A. K. (October 1999). "High treatment-related mortality in cardiac amyloid patients undergoing autologous stem cell transplant". Bone Marrow Transplantation. 24 (8): 853–855. doi: 10.1038/sj.bmt.1702005 . ISSN   1476-5365. PMID   10516696.
  10. ↑ Patel, P. R.; McDonald, M. W.; Aiello, A.; Liu, Y.; Saba, N. F.; Beitler, J. J.; Higgins, K. A. (2017-10-01). "The Relationship Between Radiation Dose And Overall Survival In Cervical Esophageal Cancer: An NCDB Analysis". International Journal of Radiation Oncology, Biology, Physics. 99 (2): E178–E179. doi: 10.1016/j.ijrobp.2017.06.1029 . ISSN   0360-3016.
  11. ↑ Evans, Michael; Baddour, Harry Michael Jr.; Magliocca, Kelly R.; Müller, Susan; Nannapaneni, Sreenivas; Chen, Amy Y.; Kim, Sunjin; Chen, Zhengjia; Shin, Dong M.; Wang, Andrew Y.; Saba, Nabil F. (2019). "Prognostic implications of peritumoral vasculature in head and neck cancer". Cancer Medicine. 8 (1): 147–154. doi:10.1002/cam4.1910. ISSN   2045-7634. PMC   6346230 . PMID   30575303.
  12. 1 2 "emory.edu". whsc.emory.edu. Retrieved 2019-10-23.
  13. 1 2 "Dr. Nabil F Saba, MD, FACP - Atlanta, GA - Medical Oncology - Request Appointment". providers.emoryhealthcare.org. Retrieved 2019-10-23.
  14. 1 2 "Nabil F. Saba, MD, FACP". winshipcancer.emory.edu. Retrieved 2019-10-23.
  15. ↑ "Nabil F. Saba, M.D. - Noticed". noticed.co. Retrieved 2019-10-23.
  16. ↑ "Profile | Emory School of Medicine". med.emory.edu. Retrieved 2019-10-23.
  17. ↑ "Nabil F. Saba, MD, FACP". winshipcancer.emory.edu. Retrieved 2019-10-23.
  18. ↑ "Dr. Nabil F Saba, MD, FACP - Atlanta, GA - Medical Oncology - Request Appointment". providers.emoryhealthcare.org. Retrieved 2019-10-23.
  19. ↑ Saba, N.; Sutton, D. M.; Ross, H. J.; Siu, S.; Crump, R. M.; Keating, A.; Stewart, A. K. (1999). "High treatment-related mortality in cardiac amyloid patients undergoing autologous stem cell transplant". Bone Marrow Transplantation. 24 (8): 853–855. doi: 10.1038/sj.bmt.1702005 . ISSN   1476-5365. PMID   10516696.
  20. ↑ Saba, Nabil F.; Goodman, Michael; Ward, Kevin; Flowers, Chris; Ramalingam, Suresh; Owonikoko, Taofeek; Chen, Amy; Grist, William; Wadsworth, Trad; Beitler, Jonathan J.; Khuri, Fadlo R. (2011). "Gender and Ethnic Disparities in Incidence and Survival of Squamous Cell Carcinoma of the Oral Tongue, Base of Tongue, and Tonsils: A Surveillance, Epidemiology and End Results Program-Based Analysis". Oncology. 81 (1): 12–20. doi:10.1159/000330807. ISSN   0030-2414. PMC   3186716 . PMID   21912193.
  21. ↑ Saba, Nabil F.; Hurwitz, Selwyn J.; Kono, Scott A.; Yang, Chung S.; Zhao, Yang; Chen, Zhengjia; Sica, Gabe; Müller, Susan; Moreno-Williams, Rachel; Lewis, Melinda; Grist, William (March 2014). "Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study". Cancer Prevention Research (Philadelphia, Pa.). 7 (3): 283–291. doi:10.1158/1940-6207.CAPR-13-0215. ISSN   1940-6215. PMC   4351876 . PMID   24085777.
  22. ↑ Saba, Nabil F.; Wang, Xu; Müller, Susan; Tighiouart, Mourad; Cho, Kwangjae; Nie, Shuming; Chen, Zhuo (Georgia); Shin, Dong M. (2009). "Examining expression of folate receptor in squamous cell carcinoma of the head and neck as a target for a novel nanotherapeutic drug". Head & Neck. 31 (4): 475–481. doi:10.1002/hed.21003. ISSN   1097-0347. PMC   2658731 . PMID   19072997.
  23. ↑ Saba, Nabil F.; Choi, Misun; Muller, Susan; Shin, Hyung Ju C.; Tighiouart, Mourad; Papadimitrakopoulou, Vassiliki A.; El-Naggar, Adel K.; Khuri, Fadlo R.; Chen, Zhuo Georgia; Shin, Dong M. (2009). "Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma". Cancer Prevention Research (Philadelphia, Pa.). 2 (9): 823–829. doi:10.1158/1940-6207.CAPR-09-0077. ISSN   1940-6215. PMC   2910364 . PMID   19737986.
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