Nancy E. Lane | |
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Academic background | |
Education | BS, 1976, University of California, Davis MD, 1980, UCSF School of Medicine |
Academic work | |
Institutions | University of California,Davis San Francisco General Hospital |
Nancy E. Lane is an American rheumatologist. She is an Endowed Professor of Medicine,Rheumatology,and Aging Research at the University of California,Davis and director of the UC Davis Musculoskeletal Diseases of Aging Research Group. She has also sat on the editorial boards of Nature Reviews Rheumatology , Rheumatology,Seminars in Arthritis and Rheumatism, Arthritis &Rheumatology, and The Journal of Rheumatology. Her work on aging and glucocorticoids in cell populations is internationally recognized.
Lane earned her Bachelor of Science degree from the University of California,Davis (UC Davis) and her medical degree from the UCSF School of Medicine. [1]
Upon completing her medical degree,Lane became an associate professor of medicine at the University of California,Davis where she treated patients at the San Francisco General Hospital. [2] In 2012,Lane received "mastership" status from the American College of Physicians [3] and was later elected a member of the Institute of Medicine. [4] During the same year,she was the recipient of a California Institute for Regenerative Medicine stem cell grant for her project targeting osteoporosis. Lane led a research group in developing a clinical trial to test a synthetic molecule that directly transplanted mesenchymal stem cells. [5] The following year,Lane was responsible for establishing a specialized research center at UC Davis to "explore the sex differences related to osteoporosis,carpal tunnel syndrome,osteoarthritis,and kyphosis." [6] In 2017,she was elected a Fellow of the American Association for the Advancement of Science for her "distinguished contributions to research in the epidemiology and genetic composition of and therapies and treatments for women’s musculoskeletal disorders,including osteoarthritis and osteoporosis." [7]
While at UC Davis,Lane focuses on the treatment of patients with osteoporosis,specifically glucocorticoid-induced osteoporosis aetiology. She has also sat on the editorial boards of Nature Reviews Rheumatology , Rheumatology,Seminars in Arthritis and Rheumatism, Arthritis &Rheumatology, and The Journal of Rheumatology. [1] In 2020,Lane was appointed to sit on the Medical and Scientific Advisory Board of the non-profit organization American Bone Health. [8]
Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness,warmth,swelling,and decreased range of motion of the affected joints. In some types of arthritis,other organs are also affected. Onset can be gradual or sudden.
Rheumatology is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones,muscles,joints,and internal organs. Rheumatology covers more than 100 different complex diseases,collectively known as rheumatic diseases,which includes many forms of arthritis as well as lupus and Sjögren's syndrome. Doctors who have undergone formal training in rheumatology are called rheumatologists.
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. It is believed to be the fourth leading cause of disability in the world,affecting 1 in 7 adults in the United States alone. The most common symptoms are joint pain and stiffness. Usually the symptoms progress slowly over years. Other symptoms may include joint swelling,decreased range of motion,and,when the back is affected,weakness or numbness of the arms and legs. The most commonly involved joints are the two near the ends of the fingers and the joint at the base of the thumbs,the knee and hip joints,and the joints of the neck and lower back. The symptoms can interfere with work and normal daily activities. Unlike some other types of arthritis,only the joints,not internal organs,are affected.
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is one of the institutes and centers that make up the National Institutes of Health,an agency of the United States Department of Health and Human Services (HHS).
Rheumatism or rheumatic disorders are conditions causing chronic,often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder,but covers at least 200 different conditions,including arthritis and "non-articular rheumatism",also known as "regional pain syndrome" or "soft tissue rheumatism". There is a close overlap between the term soft tissue disorder and rheumatism. Sometimes the term "soft tissue rheumatic disorders" is used to describe these conditions.
The University of California Davis School of Medicine is the medical school of the University of California,Davis. While the parent institution is located in Davis,California,the medical school is in Sacramento,California.
Methylprednisolone is a synthetic glucocorticoid,primarily prescribed for its anti-inflammatory and immunosuppressive effects. It is either used at low doses for chronic illnesses or used concomitantly at high doses during acute flares. Methylprednisolone and its derivatives can be administered orally or parenterally.
UC Davis Medical Center (UCDMC) is part of UC Davis Health and a major academic health center located in Sacramento,California. It is owned and operated by the University of California as part of its University of California,Davis campus. The medical center sits on a 142-acre (57 ha) campus (often referred to as the Sacramento Campus to distinguish it from the main campus in nearby Davis) located between the Elmhurst,Tahoe Park,and Oak Park residential neighborhoods. The site incorporates the land and some of the buildings of the former Sacramento Medical Center (which was acquired from the County of Sacramento in 1973) as well as much of the land (and two buildings) previously occupied by the California State Fair until its 1967 move to a new location.
The Kolling Institute is located in the grounds of the Royal North Shore Hospital in St Leonards,Sydney Australia. The institute,founded in 1920,is the oldest medical research institute in New South Wales.
Steroid-induced osteoporosis is osteoporosis arising from the use of glucocorticoids analogous to Cushing's syndrome but involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Bisphosphonates are beneficial in reducing the risk of vertebral fractures. Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone,especially when this is in excess of three months. The use of thiazide diuretics,and gonadal hormone replacement has also been recommended,with the use of calcitonin,bisphosphonates,sodium fluoride or anabolic steroids also suggested in refractory cases. Alternate day use may not prevent this complication.
Michael D. Lockshin is an American professor and medical researcher. He is known for his work as a researcher of autoimmune diseases,with focus on antiphospholipid syndrome and lupus. He is Professor Emeritus of Medicine and the Director Emeritus of the Barbara Volcker Center for Women and Rheumatic Disease at Hospital for Special Surgery. He retired from HSS on January 31,2023.
Ephraim Engleman was an American rheumatologist and a Clinical Professor of Medicine at the University of California,San Francisco. He had a major national and international impact on rheumatology during more than six decades,and wrote more than one hundred scientific and medical papers.
Jonna Ann Keener Mazet is an American epidemiologist and Executive Director of the University of California,Davis One Health Institute. Recognized for her innovative and holistic approach to emerging environmental and global health threats,she is an elected member of the National Academy of Medicine and a fellow of the American Association for the Advancement of Science. Mazet is a professor of Epidemiology and Disease Ecology at the UC Davis School of Veterinary Medicine,where she focuses on global health problem solving,especially for emerging infectious disease and conservation challenges.
Gary S. Firestein is an American rheumatologist,professor,and founding director of the Altman Clinical and Translational Research Institute (ACTRI) at the University of California San Diego and Senior Associate Vice Chancellor for Health Sciences at University of California,San Diego.
Rebecca D. Jackson was a medical researcher,medical practitioner and professor of endocrinology,diabetes and metabolism. Her research was significant in the understanding and treatment of osteoporosis. She also researches the opioid crisis in Ohio.
Rachelle Buchbinder is an Australian rheumatologist and clinical epidemiologist. Her clinical practice is in conjunction with research involving multidisciplinary projects relating to arthritis and musculoskeletal conditions. She promotes improvement of communication with patients and health literacy in the community.
Michelle Leech is the Deputy Dean of Medicine at Monash University and an academic clinician-scientist. Leech oversees the delivery of the Monash medical program and maintains an active research profile and clinical practice as a rheumatologist.
Allison Brashear is an American neurologist. As of October 2021,she has accepted a position as Vice President for Health Sciences and Dean of the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo,New York. She was dean of the UC Davis School of Medicine until November 2021 and previously served as the Walter C. Teagle Endowed Chair of Neurology at Wake Forest School of Medicine.
Lindsey A. Criswell is an American rheumatologist and physician-scientist. She is director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Criswell was vice chancellor of research at University of California,San Francisco where she held the Jean S. Engleman Distinguished Professorship in Rheumatology.
Mariana J. Kaplan is a rheumatologist and physician-scientist. She researches mechanisms of immune dysregulation,organ damage,and premature vascular disease in systemic autoimmunity. Kaplan is chief of the systemic autoimmunity branch at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.