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Nervine was a patent medicine tonic with sedative effects introduced in 1884 by Dr. Miles Medical Company (later Miles Laboratories which was absorbed into Bayer). [1] [2] [3] It is a cognate of 'Nerve', and the implication was that the material worked to calm nervousness.
One form of Nervine was formulated with the primary active ingredients sodium bromide, ammonium bromide, and potassium bromide, combined with sodium bicarbonate and citric acid in an effervescent tablet. [4]
In the late 20th and early 21st century, promulgators of alternative medicine and herbalism have begun to use the term Nervine as an adjective. This is not a term used by mainstream medicine, where anxiolytic is the preferred term.
An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn, indigestion or an upset stomach. Some antacids have been used in the treatment of constipation and diarrhea. Marketed antacids contain salts of aluminum, calcium, magnesium, or sodium. Some preparations contain a combination of two salts, such as magnesium carbonate and aluminium hydroxide.
Potassium chloride is a metal halide salt composed of potassium and chlorine. It is odorless and has a white or colorless vitreous crystal appearance. The solid dissolves readily in water, and its solutions have a salt-like taste. Potassium chloride can be obtained from ancient dried lake deposits. KCl is used as a fertilizer, in medicine, in scientific applications, domestic water softeners, and in food processing, where it may be known as E number additive E508.
Carbonated water is water containing dissolved carbon dioxide gas, either artificially injected under pressure or occurring due to natural geological processes. Carbonation causes small bubbles to form, giving the water an effervescent quality. Common forms include sparkling natural mineral water, club soda, and commercially-produced sparkling water.
Potassium bromide (KBr) is a salt, widely used as an anticonvulsant and a sedative in the late 19th and early 20th centuries, with over-the-counter use extending to 1975 in the US. Its action is due to the bromide ion. Potassium bromide is used as a veterinary drug, as an antiepileptic medication for dogs.
Hydrobromic acid is a strong acid formed by dissolving the diatomic molecule hydrogen bromide (HBr) in water. "Constant boiling" hydrobromic acid is an aqueous solution that distills at 124.3 °C (255.7 °F) and contains 47.6% HBr by mass, which is 8.77 mol/L. Hydrobromic acid has a pKa of −9, making it a stronger acid than hydrochloric acid, but not as strong as hydroiodic acid. Hydrobromic acid is one of the strongest mineral acids known.
Club soda is a manufactured form of carbonated water, commonly used as a drink mixer. Sodium bicarbonate, potassium sulfate, potassium bicarbonate, potassium citrate, or sodium citrate is artificially added to replicate constituents commonly found in natural mineral waters and offset the acidity of introducing carbon dioxide gas.
Potassium iodide is a chemical compound, medication, and dietary supplement. It is a medication used for treating hyperthyroidism, in radiation emergencies, and for protecting the thyroid gland when certain types of radiopharmaceuticals are used. In the third world it is also used for treating skin sporotrichosis and phycomycosis. It is a supplement used by people with low dietary intake of iodine. It is administered orally.
Alka-Seltzer is an effervescent antacid and pain reliever first marketed by the Dr. Miles Medicine Company of Elkhart, Indiana, United States. Alka-Seltzer contains three active ingredients: aspirin (ASA), sodium bicarbonate, and anhydrous citric acid. The aspirin is a pain reliever and anti-inflammatory, the sodium bicarbonate is an antacid, and the citric acid reacts with the sodium bicarbonate and water to form effervescence.
Sodium bromide is an inorganic compound with the formula NaBr. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.
Miles Laboratories was founded as the Dr. Miles Medical Company in Elkhart, Indiana, in 1884 by Dr. Franklin Lawrence Miles, a specialist in the treatment of eye and ear disorders, with an interest in the connection of the nervous system to overall health. The company is known for inventing products such as Alka-Selzer and One-A-Day vitamins.
A bromide ion is the negatively charged form (Br−) of the element bromine, a member of the halogens group on the periodic table. Most bromides are colorless. Bromides have many practical roles, being found in anticonvulsants, flame-retardant materials, and cell stains. Although uncommon, chronic toxicity from bromide can result in bromism, a syndrome with multiple neurological symptoms. Bromide toxicity can also cause a type of skin eruption, see potassium bromide. The bromide ion has an ionic radius of 196 pm.
Ringer's lactate solution (RL), also known as sodium lactate solution,Lactated Ringer’s, and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water. It is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure. It may also be used to treat metabolic acidosis and to wash the eye following a chemical burn. It is given by intravenous infusion or applied to the affected area.
Airborne is an American brand of dietary supplement containing herbal extracts, amino acids, antioxidants, electrolytes, vitamins, and other ingredients originally marketed as preventing the common cold and improving immune function.
Sodium thiocyanate (sometimes called sodium sulphocyanide) is the chemical compound with the formula NaSCN. This colorless deliquescent salt is one of the main sources of the thiocyanate anion. As such, it is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Thiocyanate salts are typically prepared by the reaction of cyanide with elemental sulfur:
Edwin Wiley Grove (1850–1927) was a self-made millionaire and entrepreneur. He founded the Paris Medicine Company, creating and producing its most well-known patent medicine products, Grove’s Tasteless Chill Tonic and Laxative Bromo Quinine tablets. He later invested in and developed properties in cities in the U.S. South, including Atlanta, Georgia, and Asheville, North Carolina.
Domiphen bromide is a chemical antiseptic and a quaternary ammonium compound.
Effervescent or carbon tablets are tablets which are designed to dissolve in water, and release carbon dioxide. They are products of compression of component ingredients in the form of powders into a dense mass, which is packaged in blister pack, or with a hermetically sealed package with incorporated desiccant in the cap. To use them, they are dropped into water to make a solution. The powdered ingredients are also packaged and sold as effervescent powders or may be granulated and sold as effervescent granules. Generally powdered ingredients are first granularized before being made into tablets.
The Poison Prevention Packaging Act of 1970 (PPPA); was signed into law by U.S. President Richard Nixon on December 30, 1970. It was enacted by the 91st United States Congress. This law required the use of child-resistant packaging for prescription drugs, over-the-counter (OTC) drugs, household chemicals, and other hazardous materials that could be considered dangerous for children.
After a hectic day, Dr Miles liquid Nervine
Bromides of sodium, potassium, and ammonium
