Nexafed is a formulation of pseudoephedrine developed by Acura Pharmaceuticals used to deter the use of the pseudoephedrine contained in the product for illicit methamphetamine synthesis. [1] Nexafed uses a polymer matrix that forms a thick gel when hydrated, preventing the extraction of pseudoephedrine. [2] Nexafed is the only meth-resistant formulation of pseudoephedrine that shows therapeutic equivalence to Sudafed. [3]
It is sold at various pharmacies in the US, including Fruth Pharmacy [4] [5] and Kroger, particularly in communities where illicit methamphetamine production is an issue.[ citation needed ]