In epidemiology, the next-generation matrix is used to derive the basic reproduction number, for a compartmental model of the spread of infectious diseases. In population dynamics it is used to compute the basic reproduction number for structured population models. [1] It is also used in multi-type branching models for analogous computations. [2]
The method to compute the basic reproduction ratio using the next-generation matrix is given by Diekmann et al. (1990) [3] and van den Driessche and Watmough (2002). [4] To calculate the basic reproduction number by using a next-generation matrix, the whole population is divided into compartments in which there are infected compartments. Let be the numbers of infected individuals in the infected compartment at time t. Now, the epidemic model is[ citation needed ]
In the above equations, represents the rate of appearance of new infections in compartment . represents the rate of transfer of individuals into compartment by all other means, and represents the rate of transfer of individuals out of compartment . The above model can also be written as
where
and
Let be the disease-free equilibrium. The values of the parts of the Jacobian matrix and are:
and
respectively.
Here, and are m × m matrices, defined as and .
Now, the matrix is known as the next-generation matrix. The basic reproduction number of the model is then given by the eigenvalue of with the largest absolute value (the spectral radius of ). Next generation matrices can be computationally evaluated from observational data, which is often the most productive approach where there are large numbers of compartments. [5]
In mathematics, the determinant is a scalar-valued function of the entries of a square matrix. The determinant of a matrix A is commonly denoted det(A), det A, or |A|. Its value characterizes some properties of the matrix and the linear map represented, on a given basis, by the matrix. In particular, the determinant is nonzero if and only if the matrix is invertible and the corresponding linear map is an isomorphism.
In differential geometry, a subject of mathematics, a symplectic manifold is a smooth manifold, , equipped with a closed nondegenerate differential 2-form , called the symplectic form. The study of symplectic manifolds is called symplectic geometry or symplectic topology. Symplectic manifolds arise naturally in abstract formulations of classical mechanics and analytical mechanics as the cotangent bundles of manifolds. For example, in the Hamiltonian formulation of classical mechanics, which provides one of the major motivations for the field, the set of all possible configurations of a system is modeled as a manifold, and this manifold's cotangent bundle describes the phase space of the system.
In geometry, a simplex is a generalization of the notion of a triangle or tetrahedron to arbitrary dimensions. The simplex is so-named because it represents the simplest possible polytope in any given dimension. For example,
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In linear algebra, the Cholesky decomposition or Cholesky factorization is a decomposition of a Hermitian, positive-definite matrix into the product of a lower triangular matrix and its conjugate transpose, which is useful for efficient numerical solutions, e.g., Monte Carlo simulations. It was discovered by André-Louis Cholesky for real matrices, and posthumously published in 1924. When it is applicable, the Cholesky decomposition is roughly twice as efficient as the LU decomposition for solving systems of linear equations.
In linear algebra, the Cayley–Hamilton theorem states that every square matrix over a commutative ring satisfies its own characteristic equation.
In mathematics, the name symplectic group can refer to two different, but closely related, collections of mathematical groups, denoted Sp(2n, F) and Sp(n) for positive integer n and field F (usually C or R). The latter is called the compact symplectic group and is also denoted by . Many authors prefer slightly different notations, usually differing by factors of 2. The notation used here is consistent with the size of the most common matrices which represent the groups. In Cartan's classification of the simple Lie algebras, the Lie algebra of the complex group Sp(2n, C) is denoted Cn, and Sp(n) is the compact real form of Sp(2n, C). Note that when we refer to the (compact) symplectic group it is implied that we are talking about the collection of (compact) symplectic groups, indexed by their dimension n.
In linear algebra, an invertible matrix is a square matrix which has an inverse. In other words, if some other matrix is multiplied by the invertible matrix, the result can be multiplied by an inverse to undo the operation. Invertible matrices are the same size as their inverse.
In mathematics and physics, n-dimensional anti-de Sitter space (AdSn) is a maximally symmetric Lorentzian manifold with constant negative scalar curvature. Anti-de Sitter space and de Sitter space are named after Willem de Sitter (1872–1934), professor of astronomy at Leiden University and director of the Leiden Observatory. Willem de Sitter and Albert Einstein worked together closely in Leiden in the 1920s on the spacetime structure of the universe. Paul Dirac was the first person to rigorously explore anti-de Sitter space, doing so in 1963.
In mathematics, and in particular linear algebra, the Moore–Penrose inverse of a matrix , often called the pseudoinverse, is the most widely known generalization of the inverse matrix. It was independently described by E. H. Moore in 1920, Arne Bjerhammar in 1951, and Roger Penrose in 1955. Earlier, Erik Ivar Fredholm had introduced the concept of a pseudoinverse of integral operators in 1903. The terms pseudoinverse and generalized inverse are sometimes used as synonyms for the Moore–Penrose inverse of a matrix, but sometimes applied to other elements of algebraic structures which share some but not all properties expected for an inverse element.
In linear algebra, a tridiagonal matrix is a band matrix that has nonzero elements only on the main diagonal, the subdiagonal/lower diagonal, and the supradiagonal/upper diagonal. For example, the following matrix is tridiagonal:
In mathematics, the determinant of an m-by-m skew-symmetric matrix can always be written as the square of a polynomial in the matrix entries, a polynomial with integer coefficients that only depends on m. When m is odd, the polynomial is zero, and when m is even, it is a nonzero polynomial of degree m/2, and is unique up to multiplication by ±1. The convention on skew-symmetric tridiagonal matrices, given below in the examples, then determines one specific polynomial, called the Pfaffian polynomial. The value of this polynomial, when applied to the entries of a skew-symmetric matrix, is called the Pfaffian of that matrix. The term Pfaffian was introduced by Cayley, who indirectly named them after Johann Friedrich Pfaff.
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In epidemiology, the basic reproduction number, or basic reproductive number, denoted , of an infection is the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection. The definition assumes that no other individuals are infected or immunized. Some definitions, such as that of the Australian Department of Health, add the absence of "any deliberate intervention in disease transmission". The basic reproduction number is not necessarily the same as the effective reproduction number , which is the number of cases generated in the current state of a population, which does not have to be the uninfected state. is a dimensionless number and not a time rate, which would have units of time−1, or units of time like doubling time.
Mathematical models can project how infectious diseases progress to show the likely outcome of an epidemic and help inform public health and plant health interventions. Models use basic assumptions or collected statistics along with mathematics to find parameters for various infectious diseases and use those parameters to calculate the effects of different interventions, like mass vaccination programs. The modelling can help decide which intervention(s) to avoid and which to trial, or can predict future growth patterns, etc.
Compartmental models are a very general modelling technique. They are often applied to the mathematical modelling of infectious diseases. The population is assigned to compartments with labels – for example, S, I, or R,. People may progress between compartments. The order of the labels usually shows the flow patterns between the compartments; for example SEIS means susceptible, exposed, infectious, then susceptible again.
In mathematics, Birkhoff interpolation is an extension of polynomial interpolation. It refers to the problem of finding a polynomial of degree such that only certain derivatives have specified values at specified points:
In probability theory and mathematical physics, a random matrix is a matrix-valued random variable—that is, a matrix in which some or all of its entries are sampled randomly from a probability distribution. Random matrix theory (RMT) is the study of properties of random matrices, often as they become large. RMT provides techniques like mean-field theory, diagrammatic methods, the cavity method, or the replica method to compute quantities like traces, spectral densities, or scalar products between eigenvectors. Many physical phenomena, such as the spectrum of nuclei of heavy atoms, the thermal conductivity of a lattice, or the emergence of quantum chaos, can be modeled mathematically as problems concerning large, random matrices.
In mathematical physics, the Berezin integral, named after Felix Berezin,, is a way to define integration for functions of Grassmann variables. It is not an integral in the Lebesgue sense; the word "integral" is used because the Berezin integral has properties analogous to the Lebesgue integral and because it extends the path integral in physics, where it is used as a sum over histories for fermions.
In mathematics, an ordinary differential equation (ODE) is a differential equation (DE) dependent on only a single independent variable. As with other DE, its unknown(s) consists of one function(s) and involves the derivatives of those functions. The term "ordinary" is used in contrast with partial differential equations (PDEs) which may be with respect to more than one independent variable, and, less commonly, in contrast with stochastic differential equations (SDEs) where the progression is random.
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