The Office of Biorepositories and Biospecimen Research is a division of the United States National Cancer Institute which was formed in 2005 to promote and develop biobank infrastructure.
The Office of Biorepositories and Biospecimen Research is a division of the United States National Cancer Institute which was formed in 2005 to promote and develop biobank infrastructure.
The guidelines which the OBBR published were among the first generation of policies relating to biobank ethics. [1]
The OBBR organizes an annual conference called the "Biospecimen Research Network Symposia". [2]
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the parauthera glands in women.
In epidemiology, a risk factor or determinant is a variable associated with an increased risk of disease or infection.
The Women's Health Initiative (WHI) was a series of clinical studies initiated by the U.S. National Institutes of Health (NIH) in 1991, to address major health issues causing morbidity and mortality in postmenopausal women. It consisted of three clinical trials (CT) and an observational study (OS). In particular, randomized controlled trials were designed and funded that addressed cardiovascular disease, cancer, and osteoporosis.
The Cancer Genome Atlas (TCGA) is a project to catalogue the genetic mutations responsible for cancer using genome sequencing and bioinformatics. The overarching goal was to apply high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of the disease.
A biobank is a type of biorepository that stores biological samples for use in research. Biobanks have become an important resource in medical research, supporting many types of contemporary research like genomics and personalized medicine.
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. These symptoms can include hot flashes, vaginal atrophy, accelerated skin aging, vaginal dryness, decreased muscle mass, sexual dysfunction, and bone loss or osteoporosis. They are in large part related to the diminished levels of sex hormones that occur during menopause.
A biorepository is a facility that collects, catalogs, and stores samples of biological material for laboratory research. Biorepositories collect and manage specimens from animals, plants, and other living organisms. Biorepositories store many different types of specimens, including samples of blood, urine, tissue, cells, DNA, RNA, and proteins. If the samples are from people, they may be stored with medical information along with written consent to use the samples in laboratory studies.
A Tumor Bank, A Tumor Bank is sometimes also referred to as a Tissue Bank, since normal tissues for research are also often collected. However, this function is distinct from a Tissue Bank which collects and harvests human cadaver tissue for medical research and education, and banks which store Biomedical tissue for organ transplantation.
A biological specimen is a biological laboratory specimen held by a biorepository for research. Such a specimen would be taken by sampling so as to be representative of any other specimen taken from the source of the specimen. When biological specimens are stored, ideally they remain equivalent to freshly-collected specimens for the purposes of research.
Biobank ethics refers to the ethics pertaining to all aspects of biobanks. The issues examined in the field of biobank ethics are special cases of clinical research ethics.
The International Society for Biological and Environmental Repositories (ISBER) is a professional society of individuals and organizations involved in biospecimen banking. Its main activities include creating educational and training opportunities, providing an online forum service, showcasing related products and services, and creating opportunities for networking. It also has published works.
Ellen Wright Clayton is an American academic specialzing in law and medicine. She is the Rosalind E. Franklin Professor of Genetics at Vanderbilt University and chairwoman of the Institute of Medicine Board at the Population Health and Public Health Practice. She was the 2013 recipient of the David Rall Medal.
The Undiagnosed Diseases Network (UDN) is a research study that is funded by the National Institutes of Health Common Fund. Its purpose is to bring together clinical and research experts from across the United States to solve the most challenging medical mysteries using advanced technologies.
Giuseppe Merla is an Italian scientist who is a Full Professor of Molecular Biology at University of Naples Federico II and medical geneticist at Casa Sollievo della Sofferenza in San Giovanni Rotondo, Italy. He is the Managing Director of Fondazione Telethon-Genomic and Genetics Disorders Biobank, a member of EuroBioBank at the Casa Sollievo della Sofferenza Hospital. Merla and his team led the discovery of a new rare genetic syndrome intellectual development disorder with cardiac arrhythmia and the gene responsible for it. Merla is also known for his extensive research on Kabuki Syndrome. He has been declared as the Ambassador of Kabuki syndrome and received the 2019 Ambassador Day award at the Royal Villa of Monza.
Melissa Anne Wake MBChB MD FRACP FAHMS is a New Zealand paediatrician and Scientific Director of the Generation Victoria initiative, aiming to create very large, parallel whole-of-state birth and parent cohorts in Victoria, Australia, for Open Science discovery and interventional research. She is Group Leader of the Murdoch Children's Research Institute’s Prevention Innovation Research Group and holds Professorial positions with the University of Melbourne and the University of Auckland.
Sora Park Tanjasiri is a professor in the Department of Epidemiology at the University of California, Irvine, and Associate Director for Cancer Health Disparities and Community Engagement at the UCI Chao Family Comprehensive Cancer Center. Her research focuses on community health in diverse populations, in particular Pacific Islanders and Asian Americans.
Marianne Krall Henderson is an American biomedical scientist specialized in biobanks and biorepositories. She is a senior advisor on biospecimen resources at the National Cancer Institute. Henderson was president of the International Society for Biological and Environmental Repositories from 2011 to 2012.
A. Heather Eliassen is an American public health researcher who is a professor of epidemiology at the Harvard T.H. Chan School of Public Health. Her research considers the epidemiology of breast cancer and the identification of modifiable risk factors to reduce breast cancer risk.
Daniel Richard Masys is an American biotechnologist and academic. He is an Affiliate Professor of Biomedical and Health Informatics at the University of Washington.