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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals poorly. Women may have more hair and irregular menstruation. Occasionally there may be changes in mood, headaches, and a chronic feeling of tiredness.
Harvey Williams Cushing was an American neurosurgeon, pathologist, writer, and draftsman. A pioneer of brain surgery, he was the first exclusive neurosurgeon and the first person to describe Cushing's disease. He wrote a biography of physician William Osler in three volumes.
Cushing's disease is one cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary. This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids. The equine version of this disease is Pituitary pars intermedia dysfunction.
William Cushing was one of the original five associate justices of the United States Supreme Court; confirmed by the United States Senate on September 26, 1789, he served until his death. His Supreme Court tenure of 20 years and 11 months was the longest among the Court's inaugural members. In January 1796, he was nominated by President George Washington to become the Court's Chief Justice; though confirmed, he declined the appointment. He was the last judge in the United States to wear a full wig.
Pituitary adenomas are tumors that occur in the pituitary gland. Most pituitary tumors are benign, approximately 35% are invasive and just 0.1% to 0.2% are carcinomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%.
The Medical University of Vienna is a public university located in Vienna, Austria. It is the direct successor to the faculty of medicine at the University of Vienna, founded in 1365 by Rudolf IV, Duke of Austria. As one of the oldest medical schools in the world, it is the oldest in the German-speaking countries, and was the second medical faculty in the Holy Roman Empire, after the Charles University of Prague.
Nelson's syndrome is a disorder that occurs in about one in four patients who have had both adrenal glands removed to treat Cushing's disease. In patients with pre-existing adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas, loss of adrenal feedback following bilateral adrenalectomy can trigger the rapid growth of the tumor, leading to visual symptoms and hyperpigmentation. The severity of the disease is dependent upon the effect of ACTH release on the skin, pituitary hormone loss from mass compression, as well as invasion into surrounding structures around the pituitary gland.
Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. It is a derivative of the early insecticide DDT and an isomer of p,p'-DDDTooltip dichlorodiphenyldichloroethane (4,4'-dichlorodiphenyldichloroethane) and is also known as 2,4'-(dichlorodiphenyl)-2,2-dichloroethane (o,p'-DDD).
Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; it typically results from a pituitary adenoma. In children with hyperpituitarism, disruption of growth regulation is rare, either because of hormone hypersecretion or because of manifestations caused by local compression of the adenoma.
Adam Rainer was an Austro-Hungarian man. He is the only person in recorded history to have been both a dwarf and a giant. He is believed to have had acromegaly.
Hypophysectomy is the surgical removal of the hypophysis. It is most commonly performed to treat tumors, especially craniopharyngioma tumors. Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma or Simmond's disease It is also applied in neurosciences to understand the functioning of hypophysis. There are various ways a hypophysectomy can be carried out. These methods include transsphenoidal hypophysectomy, open craniotomy, and stereotactic radiosurgery.
Brian Patrick Cushing is an American former profesional football player who was a linebacker for the Houston Texans of the National Football League (NFL). He played college football for the USC Trojans, and was selected by the Texans in the first round of the 2009 NFL Draft. He played his entire nine-year career with Houston from 2009 to 2017 and became the team's all-time leading tackler.
Ottokar Chiari was an Austrian laryngologist and professor at the University of Vienna who was a native of Prague.
Acromegaly is a disorder that results in excess growth of certain parts of the human body. It is caused by excess growth hormone (GH) after the growth plates have closed. The initial symptom is typically enlargement of the hands and feet. There may also be an enlargement of the forehead, jaw, and nose. Other symptoms may include joint pain, thicker skin, deepening of the voice, headaches, and problems with vision. Complications of the disease may include type 2 diabetes, sleep apnea, and high blood pressure.
The following events occurred in March 1909:
The following events occurred in June 1910:
Bonnie & Clyde is a revisionist 2013 miniseries about Great Depression-era outlaws Bonnie Parker and Clyde Barrow starring Emile Hirsch as Clyde Barrow and Holliday Grainger as Bonnie Parker. The two-part series aired on consecutive nights, December 8 and 9, 2013, simultaneously on A&E, History, and Lifetime. The first previews were released on September 23, 2013. The series was widely criticized for its historical inaccuracies, particularly as it was aired on History.
Endoscopic endonasal surgery is a minimally invasive technique used mainly in neurosurgery and otolaryngology. A neurosurgeon or an otolaryngologist, using an endoscope that is entered through the nose, fixes or removes brain defects or tumors in the anterior skull base. Normally an otolaryngologist performs the initial stage of surgery through the nasal cavity and sphenoid bone; a neurosurgeon performs the rest of the surgery involving drilling into any cavities containing a neural organ such as the pituitary gland. The use of endoscope was first introduced in Transsphenoidal Pituitary Surgery by R Jankowsky, J Auque, C Simon et al. in 1992 G.
Theodore H. Schwartz is an American medical scientist, academic physician and neurosurgeon.
Arthur Schüller was an Austrian medical doctor who served as professor at Vienna University and was the founder of the discipline of neuroradiology. He is credited with coining the term "Neuro-Röntgenologie" and he contributed particularly to three neurosurgical procedures; antero-cordotomy, cisternal hydrocephalic drainage and the transsphenoidal approach to pituitary tumours, and is associated with three bone diseases; the Hand–Schüller–Christian disease, osteoporosis circumscripta and cephalohaematoma deformans.
References
- ↑ "Oskar Hirsch". gedenkbuch.univie.ac.at (in German). 2009-10-27. Retrieved 3 December 2013.
- ↑ Liu, JK.; Cohen-Gadol, AA.; Laws, ER.; Cole, CD.; Kan, P.; Couldwell, WT.; Cushing, H.; Hirsch, O. (Dec 2005). "Harvey Cushing and Oskar Hirsch: early forefathers of modern transsphenoidal surgery". J Neurosurg. 103 (6): 1096–104. doi: 10.3171/jns.2005.103.6.1096 . PMID 16381201.
- ↑ Lanzino, Giuseppe; Laws, Edward R. Jr.; Feiz-Erfan, Iman; White, William L. (2002). "Transsphenoidal Approach to Lesions of the Sella Turcica: Historical Overview". Barrow Quarterly (18 ed.). Barrow Neurological Institute (3). Retrieved 3 December 2013.
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